4Q9O
Crystal structure of Upps + inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004659 | molecular_function | prenyltransferase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0008834 | molecular_function | di-trans,poly-cis-undecaprenyl-diphosphate synthase activity |
| A | 0016094 | biological_process | polyprenol biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0045547 | molecular_function | dehydrodolichyl diphosphate synthase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004659 | molecular_function | prenyltransferase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0008834 | molecular_function | di-trans,poly-cis-undecaprenyl-diphosphate synthase activity |
| B | 0016094 | biological_process | polyprenol biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0045547 | molecular_function | dehydrodolichyl diphosphate synthase activity |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 2ZW A 301 |
| Chain | Residue |
| A | MET49 |
| A | LEU102 |
| A | ALA129 |
| A | PHE143 |
| A | LEU52 |
| A | GLN53 |
| A | ALA71 |
| A | ILE87 |
| A | PRO91 |
| A | PHE94 |
| A | TYR98 |
| A | VAL99 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 302 |
| Chain | Residue |
| A | GLY29 |
| A | ASN30 |
| A | GLY31 |
| A | ARG32 |
| A | ARG41 |
| A | HIS45 |
| A | ARG79 |
| A | HOH466 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 2ZW B 301 |
| Chain | Residue |
| B | MET49 |
| B | GLN53 |
| B | ALA71 |
| B | ILE87 |
| B | PRO91 |
| B | PHE94 |
| B | TYR98 |
| B | VAL99 |
| B | LEU102 |
| B | ALA129 |
| B | PHE143 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 302 |
| Chain | Residue |
| B | ASN30 |
| B | GLY31 |
| B | ARG32 |
| B | ARG41 |
| B | HIS45 |
| B | ARG79 |
Functional Information from PROSITE/UniProt
| site_id | PS01066 |
| Number of Residues | 18 |
| Details | UPP_SYNTHASE Undecaprenyl pyrophosphate synthase family signature. DLIIRTSGelRlSnFLPW |
| Chain | Residue | Details |
| A | ASP196-TRP213 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_01139 |
| Chain | Residue | Details |
| A | ASP28 | |
| B | ASP28 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_01139 |
| Chain | Residue | Details |
| A | ASN76 | |
| B | ASN76 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 22 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01139 |
| Chain | Residue | Details |
| A | ASP28 | |
| A | ARG206 | |
| A | GLU219 | |
| B | ASP28 | |
| B | GLY29 | |
| B | TRP33 | |
| B | ARG41 | |
| B | HIS45 | |
| B | SER73 | |
| B | TRP77 | |
| B | ARG79 | |
| A | GLY29 | |
| B | ARG200 | |
| B | ARG206 | |
| B | GLU219 | |
| A | TRP33 | |
| A | ARG41 | |
| A | HIS45 | |
| A | SER73 | |
| A | TRP77 | |
| A | ARG79 | |
| A | ARG200 |
