4Q93

Crystal structure of resveratrol bound human tyrosyl tRNA synthetase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004812	molecular_function	aminoacyl-tRNA ligase activity
A	0004831	molecular_function	tyrosine-tRNA ligase activity
A	0005524	molecular_function	ATP binding
A	0006418	biological_process	tRNA aminoacylation for protein translation
A	0006437	biological_process	tyrosyl-tRNA aminoacylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE STL A 401

Chain	Residue
A	TYR39
A	HOH654
A	HOH711
A	GLY41
A	LEU72
A	HIS77
A	TYR166
A	GLN170
A	ASP173
A	GLN182
A	HOH583

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 402

Chain	Residue
A	LYS282
A	TRP283
A	HOH555
A	HOH595

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 403

Chain	Residue
A	LYS26
A	ARG34

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 404

Chain	Residue
A	HIS305
A	PRO306
A	GLY307
A	HOH567
A	HOH570

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 405

Chain	Residue
A	HIS12
A	ARG16

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 406

Chain	Residue
A	LYS114
A	ASP280
A	GLU281
A	HOH687
A	HOH690
A	HOH694
A	HOH709

---

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 407

Chain	Residue
A	ALA51
A	GLY217
A	LEU218
A	THR219
A	LYS231
A	HOH556
A	HOH607
A	HOH638
A	HOH718

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 408

Chain	Residue
A	LYS265
A	HIS266
A	HOH725
A	HOH726

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 409

Chain	Residue
A	SER126
A	LYS127
A	GLU128
A	HIS143
A	LYS146

---

site_id	BC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GOL A 410

Chain	Residue
A	HOH729

---

site_id	BC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PO4 A 411

Chain	Residue
A	ARG189

---

site_id	BC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PO4 A 412

Chain	Residue
A	LYS265

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:25533949, ECO:0007744|PDB:4Q93

Chain	Residue	Details
A	TYR39
A	GLN170
A	ASP173

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:14671330, ECO:0007744|PDB:4QBT

Chain	Residue	Details
A	GLN188
A	TYR166

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:19413330

Chain	Residue	Details
A	MET1

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N-acetylglycine; in Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed => ECO:0000269|Ref.8, ECO:0007744|PubMed:19413330

Chain	Residue	Details
A	GLY2

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS206
A	LYS197

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER205

---