4Q8B

The crystal structure of CotA laccase complexed with sinapic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005507	molecular_function	copper ion binding
A	0016491	molecular_function	oxidoreductase activity
A	0030288	cellular_component	outer membrane-bounded periplasmic space
A	0030435	biological_process	sporulation resulting in formation of a cellular spore
A	0046872	molecular_function	metal ion binding
B	0005507	molecular_function	copper ion binding
B	0016491	molecular_function	oxidoreductase activity
B	0030288	cellular_component	outer membrane-bounded periplasmic space
B	0030435	biological_process	sporulation resulting in formation of a cellular spore
B	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CU A 601

Chain	Residue
A	HIS419
A	CYS492
A	HIS497
A	MET502

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CU A 602

Chain	Residue
A	HOH741
A	HIS105
A	HIS107
A	HIS422
A	HIS424
A	OXY605

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CU A 603

Chain	Residue
A	HIS155
A	HIS424
A	HIS491
A	OXY605

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CU A 604

Chain	Residue
A	HIS107
A	HIS153
A	HIS493
A	OXY605

---

site_id	AC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE OXY A 605

Chain	Residue
A	HIS105
A	HIS107
A	HIS153
A	HIS155
A	HIS422
A	HIS424
A	HIS491
A	HIS493
A	CU602
A	CU603
A	CU604
A	HOH1144

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 607

Chain	Residue
A	SER186
A	ARG248

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 608

Chain	Residue
A	ASN264
A	SER293

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 609

Chain	Residue
A	HOH1146
A	HOH1147
A	HOH1150
A	HOH1151
A	HOH1152
A	HOH1153

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 610

Chain	Residue
A	HOH751
A	HOH986
A	HOH1108
A	HOH1154

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CU B 601

Chain	Residue
B	HIS419
B	CYS492
B	HIS497
B	MET502

---

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CU B 602

Chain	Residue
B	HIS105
B	HIS107
B	HIS422
B	HIS424
B	CU603
B	HOH721

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CU B 603

Chain	Residue
B	HIS155
B	HIS424
B	HIS491
B	CU602
B	HOH701

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CU B 604

Chain	Residue
B	HIS107
B	HIS153
B	HIS493
B	HOH701

---

site_id	BC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SXX B 605

Chain	Residue
B	PRO226
B	GLY376
B	THR377
B	LEU386
B	THR415
B	ARG416
B	GLY417
B	HOH774
B	HOH945
B	HOH1074

---

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PGE B 606

Chain	Residue
B	LYS25
B	TYR27
B	TYR69

---

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 607

Chain	Residue
B	GLY376
B	GLN442
B	HOH945

---

site_id	BC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 608

Chain	Residue
B	GLY404

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	72
Details	Domain: {"description":"Plastocyanin-like 1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	154
Details	Domain: {"description":"Plastocyanin-like 2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	156
Details	Domain: {"description":"Plastocyanin-like 3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	262
Details	Domain: {"description":"Plastocyanin-like 4","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"description":"type 2 copper site","evidences":[{"source":"PubMed","id":"12637519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14764581","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16234932","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20822511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1GSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OF0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W6W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W8E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BHF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2X87","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2X88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZDW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	Binding site: {"description":"type 3 copper site","evidences":[{"source":"PubMed","id":"12637519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14764581","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16234932","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20822511","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27050268","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1GSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OF0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W6W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W8E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BHF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2X87","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2X88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZDW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YVN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YVU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	Binding site: {"description":"type 1 copper site","evidences":[{"source":"PubMed","id":"12637519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14764581","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16234932","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20822511","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27050268","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1GSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OF0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W6W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W8E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BHF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2X87","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2X88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZDW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YVN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YVU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"description":"type 1 copper site","evidences":[{"source":"PubMed","id":"12637519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16234932","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20822511","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27050268","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1GSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OF0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W8E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BHF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2X87","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2X88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YVN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YVU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Site: {"description":"Plays a crucial role in the protonation steps","evidences":[{"source":"PubMed","id":"22481612","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Site: {"description":"Plays a crucial role in the protonation steps","evidences":[{"source":"PubMed","id":"20200715","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"20822511","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22481612","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---