4Q4E
Crystal structure of E.coli aminopeptidase N in complex with actinonin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004177 | molecular_function | aminopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016285 | molecular_function | alanyl aminopeptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 901 |
| Chain | Residue |
| A | HIS297 |
| A | HIS301 |
| A | GLU320 |
| A | BB2902 |
| site_id | AC2 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE BB2 A 902 |
| Chain | Residue |
| A | TYR275 |
| A | HIS297 |
| A | GLU298 |
| A | HIS301 |
| A | GLU320 |
| A | ASP327 |
| A | TYR376 |
| A | TYR381 |
| A | ARG783 |
| A | ARG825 |
| A | ZN901 |
| A | GOL903 |
| A | HOH1780 |
| A | HOH1994 |
| A | ASN259 |
| A | MET260 |
| A | GLY261 |
| A | ALA262 |
| A | GLU264 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 903 |
| Chain | Residue |
| A | TYR275 |
| A | ASP290 |
| A | ARG293 |
| A | BB2902 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 904 |
| Chain | Residue |
| A | ASN623 |
| A | GLY791 |
| A | ARG832 |
| A | HOH1783 |
| A | HOH1911 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 905 |
| Chain | Residue |
| A | THR393 |
| A | LEU394 |
| A | ASN507 |
| A | HOH1329 |
| A | HOH1593 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 906 |
| Chain | Residue |
| A | THR393 |
| A | ALA486 |
| A | GLU535 |
| A | HOH1509 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 907 |
| Chain | Residue |
| A | SER112 |
| A | PHE194 |
| A | ASP216 |
| A | ALA254 |
| A | VAL255 |
| A | ASP256 |
| A | HOH1478 |
| A | HOH1819 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 908 |
| Chain | Residue |
| A | GLU627 |
| A | LEU628 |
| A | PHE629 |
| A | ASP630 |
| A | ARG835 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 909 |
| Chain | Residue |
| A | TRP74 |
| A | GLU671 |
| A | HOH1135 |
| A | HOH1923 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 910 |
| Chain | Residue |
| A | PHE704 |
| A | GLU734 |
| A | TYR735 |
| A | LYS738 |
| A | TRP739 |
| A | HOH1835 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NA A 911 |
| Chain | Residue |
| A | THR26 |
| A | VAL35 |
| A | THR37 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VIGHEYFHNW |
| Chain | Residue | Details |
| A | VAL294-TRP303 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"16885166","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"18416562","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"19622865","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
