4Q3F

Human D-DT complexed with tartrate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004167	molecular_function	dopachrome isomerase activity
A	0005126	molecular_function	cytokine receptor binding
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0010760	biological_process	negative regulation of macrophage chemotaxis
A	0016829	molecular_function	lyase activity
A	0032760	biological_process	positive regulation of tumor necrosis factor production
A	0033981	molecular_function	D-dopachrome decarboxylase activity
A	0042438	biological_process	melanin biosynthetic process
A	0050178	molecular_function	phenylpyruvate tautomerase activity
A	0050729	biological_process	positive regulation of inflammatory response
A	0070062	cellular_component	extracellular exosome
A	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
B	0004167	molecular_function	dopachrome isomerase activity
B	0005126	molecular_function	cytokine receptor binding
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0010760	biological_process	negative regulation of macrophage chemotaxis
B	0016829	molecular_function	lyase activity
B	0032760	biological_process	positive regulation of tumor necrosis factor production
B	0033981	molecular_function	D-dopachrome decarboxylase activity
B	0042438	biological_process	melanin biosynthetic process
B	0050178	molecular_function	phenylpyruvate tautomerase activity
B	0050729	biological_process	positive regulation of inflammatory response
B	0070062	cellular_component	extracellular exosome
B	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
C	0004167	molecular_function	dopachrome isomerase activity
C	0005126	molecular_function	cytokine receptor binding
C	0005615	cellular_component	extracellular space
C	0005737	cellular_component	cytoplasm
C	0010760	biological_process	negative regulation of macrophage chemotaxis
C	0016829	molecular_function	lyase activity
C	0032760	biological_process	positive regulation of tumor necrosis factor production
C	0033981	molecular_function	D-dopachrome decarboxylase activity
C	0042438	biological_process	melanin biosynthetic process
C	0050178	molecular_function	phenylpyruvate tautomerase activity
C	0050729	biological_process	positive regulation of inflammatory response
C	0070062	cellular_component	extracellular exosome
C	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE TLA A 201

Chain	Residue
A	PRO1
A	HOH474
A	HOH484
A	PHE2
A	LYS32
A	ARG36
A	SER63
A	ILE64
A	LYS109
A	MET114
A	HOH401

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site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE TLA B 201

Chain	Residue
B	PRO1
B	PHE2
B	LYS32
B	ARG36
B	SER63
B	ILE64
B	HOH357
B	HOH387
B	HOH404
B	HOH443
B	HOH489

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site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE TLA C 201

Chain	Residue
C	PRO1
C	PHE2
C	LYS32
C	ARG36
C	SER63
C	ILE64
C	HOH406
C	HOH436

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Functional Information from PROSITE/UniProt

site_id	PS01158
Number of Residues	15
Details	MIF Macrophage migration inhibitory factor family signature. EPCAqlsIsSIGvVG

Chain	Residue	Details
A	GLU54-GLY68

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	MOD_RES: N-acetylproline => ECO:0000250|UniProtKB:O35215

Chain	Residue	Details
A	PRO1
B	PRO1
C	PRO1

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site_id	SWS_FT_FI2
Number of Residues	3
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:O35215

Chain	Residue	Details
A	LYS32
B	LYS32
C	LYS32

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