4Q31
The crystal structure of cystathione gamma lyase (CalE6) from Micromonospora echinospora
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0016846 | molecular_function | carbon-sulfur lyase activity |
| A | 0018826 | molecular_function | methionine gamma-lyase activity |
| A | 0019346 | biological_process | transsulfuration |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0047982 | molecular_function | homocysteine desulfhydrase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0016846 | molecular_function | carbon-sulfur lyase activity |
| B | 0018826 | molecular_function | methionine gamma-lyase activity |
| B | 0019346 | biological_process | transsulfuration |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0047982 | molecular_function | homocysteine desulfhydrase activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0016846 | molecular_function | carbon-sulfur lyase activity |
| C | 0018826 | molecular_function | methionine gamma-lyase activity |
| C | 0019346 | biological_process | transsulfuration |
| C | 0030170 | molecular_function | pyridoxal phosphate binding |
| C | 0047982 | molecular_function | homocysteine desulfhydrase activity |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0016846 | molecular_function | carbon-sulfur lyase activity |
| D | 0018826 | molecular_function | methionine gamma-lyase activity |
| D | 0019346 | biological_process | transsulfuration |
| D | 0030170 | molecular_function | pyridoxal phosphate binding |
| D | 0047982 | molecular_function | homocysteine desulfhydrase activity |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0016846 | molecular_function | carbon-sulfur lyase activity |
| E | 0018826 | molecular_function | methionine gamma-lyase activity |
| E | 0019346 | biological_process | transsulfuration |
| E | 0030170 | molecular_function | pyridoxal phosphate binding |
| E | 0047982 | molecular_function | homocysteine desulfhydrase activity |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0016846 | molecular_function | carbon-sulfur lyase activity |
| F | 0018826 | molecular_function | methionine gamma-lyase activity |
| F | 0019346 | biological_process | transsulfuration |
| F | 0030170 | molecular_function | pyridoxal phosphate binding |
| F | 0047982 | molecular_function | homocysteine desulfhydrase activity |
| G | 0003824 | molecular_function | catalytic activity |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0016846 | molecular_function | carbon-sulfur lyase activity |
| G | 0018826 | molecular_function | methionine gamma-lyase activity |
| G | 0019346 | biological_process | transsulfuration |
| G | 0030170 | molecular_function | pyridoxal phosphate binding |
| G | 0047982 | molecular_function | homocysteine desulfhydrase activity |
| H | 0003824 | molecular_function | catalytic activity |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0016846 | molecular_function | carbon-sulfur lyase activity |
| H | 0018826 | molecular_function | methionine gamma-lyase activity |
| H | 0019346 | biological_process | transsulfuration |
| H | 0030170 | molecular_function | pyridoxal phosphate binding |
| H | 0047982 | molecular_function | homocysteine desulfhydrase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE MES A 401 |
| Chain | Residue |
| A | TYR100 |
| A | LLP197 |
| A | VAL322 |
| A | SER323 |
| A | LEU324 |
| A | ARG358 |
| A | HOH591 |
| A | HOH651 |
| B | TYR46 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 402 |
| Chain | Residue |
| A | ARG168 |
| A | HOH610 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 404 |
| Chain | Residue |
| A | ARG168 |
| A | LEU217 |
| A | ALA220 |
| A | HOH538 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 405 |
| Chain | Residue |
| A | SER18 |
| A | PRO27 |
| A | HIS29 |
| A | GLU56 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 406 |
| Chain | Residue |
| A | GLU65 |
| A | ARG66 |
| A | ALA185 |
| A | ARG213 |
| A | HOH568 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 407 |
| Chain | Residue |
| A | ARG48 |
| A | THR226 |
| A | THR227 |
| A | HOH629 |
| B | TYR100 |
| B | ALA101 |
| B | GLY102 |
| B | MES401 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT A 408 |
| Chain | Residue |
| A | ARG15 |
| A | PRO17 |
| A | SER18 |
| A | GLY22 |
| A | ASP23 |
| site_id | AC8 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE MES B 401 |
| Chain | Residue |
| A | TYR46 |
| A | GOL407 |
| A | HOH629 |
| B | TYR100 |
| B | LLP197 |
| B | VAL322 |
| B | SER323 |
| B | LEU324 |
| B | THR338 |
| B | ARG358 |
| B | HOH568 |
| B | HOH690 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 403 |
| Chain | Residue |
| B | ARG253 |
| B | ILE363 |
| B | GLU364 |
| B | ASP365 |
| C | GLY7 |
| C | SER248 |
| C | LEU249 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 404 |
| Chain | Residue |
| B | ARG66 |
| B | LEU184 |
| B | ALA185 |
| B | ARG213 |
| B | HOH674 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 405 |
| Chain | Residue |
| A | GLY105 |
| B | THR226 |
| B | THR227 |
| B | HOH649 |
| B | HOH665 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 406 |
| Chain | Residue |
| B | ARG16 |
| B | PRO17 |
| B | SER18 |
| B | HIS29 |
| B | GLU56 |
| D | HOH605 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 407 |
| Chain | Residue |
| B | VAL274 |
| B | HIS275 |
| B | TYR276 |
| B | GLU281 |
| B | HIS282 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 408 |
| Chain | Residue |
| B | GLY166 |
| B | ALA167 |
| B | ASP189 |
| site_id | BC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE MES C 401 |
| Chain | Residue |
| C | TYR100 |
| C | LLP197 |
| C | SER323 |
| C | LEU324 |
| C | THR338 |
| C | ARG358 |
| C | HOH611 |
| C | HOH645 |
| D | TYR46 |
| site_id | BC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL C 402 |
| Chain | Residue |
| C | ARG168 |
| site_id | BC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL C 403 |
| Chain | Residue |
| C | ARG112 |
| G | ASP136 |
| site_id | BC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL C 404 |
| Chain | Residue |
| C | GLU65 |
| C | LEU184 |
| C | ALA185 |
| C | ARG213 |
| site_id | CC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE FMT C 405 |
| Chain | Residue |
| C | ARG168 |
| site_id | CC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MES D 401 |
| Chain | Residue |
| D | LLP197 |
| D | SER323 |
| D | LEU324 |
| D | ARG358 |
| D | HOH577 |
| D | HOH629 |
| C | TYR46 |
| D | TYR100 |
| site_id | CC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL D 402 |
| Chain | Residue |
| D | ARG168 |
| site_id | CC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL D 404 |
| Chain | Residue |
| D | GLU65 |
| D | ARG66 |
| D | LEU184 |
| D | ALA185 |
| D | ARG213 |
| site_id | CC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL D 405 |
| Chain | Residue |
| C | ALA101 |
| C | GLY102 |
| C | GLY105 |
| D | THR226 |
| D | THR227 |
| D | HOH656 |
| D | HOH690 |
| D | HOH691 |
| site_id | CC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL D 406 |
| Chain | Residue |
| D | ARG168 |
| D | HOH679 |
| site_id | CC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL D 407 |
| Chain | Residue |
| B | HOH585 |
| D | ARG15 |
| D | ARG16 |
| D | PRO17 |
| D | SER18 |
| D | GLY22 |
| D | ASP23 |
| site_id | CC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MES E 401 |
| Chain | Residue |
| E | TYR100 |
| E | LLP197 |
| E | SER323 |
| E | LEU324 |
| E | ARG358 |
| E | GOL406 |
| E | HOH533 |
| F | TYR46 |
| site_id | CC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL E 402 |
| Chain | Residue |
| E | ARG168 |
| site_id | DC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL E 403 |
| Chain | Residue |
| E | ARG66 |
| E | LEU184 |
| E | ALA185 |
| E | ARG213 |
| E | HOH719 |
| site_id | DC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL E 404 |
| Chain | Residue |
| E | ARG48 |
| E | THR227 |
| E | HOH706 |
| F | ALA101 |
| F | GLY102 |
| F | MES401 |
| site_id | DC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL E 405 |
| Chain | Residue |
| E | LEU86 |
| E | ARG168 |
| E | LEU217 |
| E | ALA220 |
| E | HOH733 |
| site_id | DC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL E 406 |
| Chain | Residue |
| E | TYR100 |
| E | ALA101 |
| E | GLY102 |
| E | MES401 |
| F | ARG48 |
| F | THR227 |
| site_id | DC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MES F 401 |
| Chain | Residue |
| E | TYR46 |
| E | GOL404 |
| F | TYR100 |
| F | SER323 |
| F | LEU324 |
| F | THR338 |
| F | ARG358 |
| F | HOH559 |
| site_id | DC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL F 402 |
| Chain | Residue |
| F | ARG168 |
| site_id | DC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL F 403 |
| Chain | Residue |
| F | ARG168 |
| F | LEU217 |
| F | ALA220 |
| F | HOH621 |
| F | HOH699 |
| site_id | DC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL F 404 |
| Chain | Residue |
| F | ARG253 |
| G | LEU249 |
| G | HIS252 |
| G | HOH605 |
| site_id | DC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL F 405 |
| Chain | Residue |
| F | ARG66 |
| F | ALA185 |
| F | ARG213 |
| site_id | EC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE FMT F 406 |
| Chain | Residue |
| F | PRO68 |
| F | PHE69 |
| F | ALA70 |
| site_id | EC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MES G 401 |
| Chain | Residue |
| G | TYR100 |
| G | LLP197 |
| G | SER323 |
| G | LEU324 |
| G | ARG358 |
| G | HOH623 |
| G | HOH692 |
| H | TYR46 |
| site_id | EC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL G 402 |
| Chain | Residue |
| G | ARG168 |
| site_id | EC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL G 403 |
| Chain | Residue |
| G | GLU65 |
| G | ARG66 |
| G | LEU184 |
| G | ARG213 |
| G | HOH707 |
| site_id | EC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL G 404 |
| Chain | Residue |
| F | SER248 |
| F | LEU249 |
| G | ARG253 |
| site_id | EC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL G 405 |
| Chain | Residue |
| G | ARG48 |
| G | THR227 |
| G | HOH706 |
| G | HOH708 |
| H | ALA101 |
| H | GLY102 |
| H | MES401 |
| site_id | EC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL G 406 |
| Chain | Residue |
| G | ARG36 |
| G | ARG37 |
| G | HOH560 |
| H | CYS320 |
| site_id | EC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL G 407 |
| Chain | Residue |
| G | ALA290 |
| G | GLN291 |
| G | MSE292 |
| G | SER293 |
| G | HOH600 |
| site_id | EC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE FMT G 408 |
| Chain | Residue |
| G | ARG168 |
| site_id | FC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE MES H 401 |
| Chain | Residue |
| G | TYR46 |
| G | GOL405 |
| H | TYR100 |
| H | LLP197 |
| H | VAL322 |
| H | SER323 |
| H | LEU324 |
| H | ARG358 |
| H | HOH574 |
| H | HOH688 |
| site_id | FC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL H 402 |
| Chain | Residue |
| H | ARG168 |
| site_id | FC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL H 403 |
| Chain | Residue |
| H | MSE337 |
| site_id | FC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL H 404 |
| Chain | Residue |
| H | ARG66 |
| H | LEU184 |
| H | ARG213 |
| site_id | FC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE FMT H 405 |
| Chain | Residue |
| H | ARG168 |
Functional Information from PROSITE/UniProt
| site_id | PS00211 |
| Number of Residues | 15 |
| Details | ABC_TRANSPORTER_1 ABC transporters family signature. FSSGQAAAATLLSLV |
| Chain | Residue | Details |
| A | PHE73-VAL87 |
