4Q0M
Crystal structure of Pyrococcus furiosus L-asparaginase
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PO4 A 401 |
| Chain | Residue |
| A | GLY10 |
| A | HOH552 |
| A | HOH578 |
| A | HOH590 |
| A | THR11 |
| A | ASP51 |
| A | SER52 |
| A | GLY82 |
| A | THR83 |
| A | ASP84 |
| A | TYR273 |
| A | HOH524 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 402 |
| Chain | Residue |
| A | PRO200 |
| A | LYS201 |
| A | VAL202 |
| A | ILE208 |
| A | PRO209 |
| A | GLY210 |
| A | LEU211 |
| A | SER212 |
| A | TYR224 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 403 |
| Chain | Residue |
| A | TYR168 |
| A | LYS186 |
| A | ASN319 |
| A | GLY322 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 404 |
| Chain | Residue |
| A | GLY134 |
| A | ILE135 |
| A | ARG136 |
| A | ILE184 |
| A | PHE187 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE 4CS A 405 |
| Chain | Residue |
| A | TYR68 |
| A | VAL192 |
| A | THR193 |
| A | LEU194 |
| A | ASN307 |
| A | ASN308 |
| A | HOH595 |
Functional Information from PROSITE/UniProt
| site_id | PS00917 |
| Number of Residues | 11 |
| Details | ASN_GLN_ASE_2 Asparaginase / glutaminase active site signature 2. GiIvtHGTDTL |
| Chain | Residue | Details |
| A | GLY76-LEU86 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 318 |
| Details | Domain: {"description":"Asparaginase/glutaminase","evidences":[{"source":"PROSITE-ProRule","id":"PRU01068","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Region: {"description":"Important for activity at high temperatures","evidences":[{"source":"PubMed","id":"33303914","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile; O-isoaspartyl threonine intermediate","evidences":[{"source":"PubMed","id":"25478837","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"25478837","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25478837","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4NJE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5B5U","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
