Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4PZU

Crystal structure of a putative uncharacterize protein Rv3404c and likely sugar N-formyltransferase from Mycobacterium tuberculosis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004479	molecular_function	methionyl-tRNA formyltransferase activity
A	0005829	cellular_component	cytosol
A	0006413	biological_process	translational initiation
A	0009058	biological_process	biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016742	molecular_function	hydroxymethyl-, formyl- and related transferase activity
A	0042803	molecular_function	protein homodimerization activity
A	0071951	biological_process	conversion of methionyl-tRNA to N-formyl-methionyl-tRNA
B	0004479	molecular_function	methionyl-tRNA formyltransferase activity
B	0005829	cellular_component	cytosol
B	0006413	biological_process	translational initiation
B	0009058	biological_process	biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016742	molecular_function	hydroxymethyl-, formyl- and related transferase activity
B	0042803	molecular_function	protein homodimerization activity
B	0071951	biological_process	conversion of methionyl-tRNA to N-formyl-methionyl-tRNA
C	0004479	molecular_function	methionyl-tRNA formyltransferase activity
C	0005829	cellular_component	cytosol
C	0006413	biological_process	translational initiation
C	0009058	biological_process	biosynthetic process
C	0016740	molecular_function	transferase activity
C	0016742	molecular_function	hydroxymethyl-, formyl- and related transferase activity
C	0042803	molecular_function	protein homodimerization activity
C	0071951	biological_process	conversion of methionyl-tRNA to N-formyl-methionyl-tRNA
D	0004479	molecular_function	methionyl-tRNA formyltransferase activity
D	0005829	cellular_component	cytosol
D	0006413	biological_process	translational initiation
D	0009058	biological_process	biosynthetic process
D	0016740	molecular_function	transferase activity
D	0016742	molecular_function	hydroxymethyl-, formyl- and related transferase activity
D	0042803	molecular_function	protein homodimerization activity
D	0071951	biological_process	conversion of methionyl-tRNA to N-formyl-methionyl-tRNA
E	0004479	molecular_function	methionyl-tRNA formyltransferase activity
E	0005829	cellular_component	cytosol
E	0006413	biological_process	translational initiation
E	0009058	biological_process	biosynthetic process
E	0016740	molecular_function	transferase activity
E	0016742	molecular_function	hydroxymethyl-, formyl- and related transferase activity
E	0042803	molecular_function	protein homodimerization activity
E	0071951	biological_process	conversion of methionyl-tRNA to N-formyl-methionyl-tRNA
F	0004479	molecular_function	methionyl-tRNA formyltransferase activity
F	0005829	cellular_component	cytosol
F	0006413	biological_process	translational initiation
F	0009058	biological_process	biosynthetic process
F	0016740	molecular_function	transferase activity
F	0016742	molecular_function	hydroxymethyl-, formyl- and related transferase activity
F	0042803	molecular_function	protein homodimerization activity
F	0071951	biological_process	conversion of methionyl-tRNA to N-formyl-methionyl-tRNA
G	0004479	molecular_function	methionyl-tRNA formyltransferase activity
G	0005829	cellular_component	cytosol
G	0006413	biological_process	translational initiation
G	0009058	biological_process	biosynthetic process
G	0016740	molecular_function	transferase activity
G	0016742	molecular_function	hydroxymethyl-, formyl- and related transferase activity
G	0042803	molecular_function	protein homodimerization activity
G	0071951	biological_process	conversion of methionyl-tRNA to N-formyl-methionyl-tRNA
H	0004479	molecular_function	methionyl-tRNA formyltransferase activity
H	0005829	cellular_component	cytosol
H	0006413	biological_process	translational initiation
H	0009058	biological_process	biosynthetic process
H	0016740	molecular_function	transferase activity
H	0016742	molecular_function	hydroxymethyl-, formyl- and related transferase activity
H	0042803	molecular_function	protein homodimerization activity
H	0071951	biological_process	conversion of methionyl-tRNA to N-formyl-methionyl-tRNA

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 301

Chain	Residue
A	SER131
A	GLY194
A	ASN198
A	ARG201
A	HOH465
A	HOH551
B	PHE213

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 302

Chain	Residue
A	ARG77
A	CYS78
A	GLU111
A	ILE112
A	ILE73
A	VAL76

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 303

Chain	Residue
A	TYR30
A	CYS43
A	ARG48

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO B 301

Chain	Residue
A	PHE213
B	SER131
B	GLY194
B	ASN198
B	ARG201
B	HOH473
B	HOH528

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO B 302

Chain	Residue
B	ILE73
B	VAL76
B	ARG77
B	CYS78
B	GLU111
B	ILE112

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO B 303

Chain	Residue
B	TYR30
B	CYS43
B	ARG48
B	HOH515

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO C 301

Chain	Residue
C	SER131
C	GLY194
C	ASN198
C	ARG201
C	HOH527
C	HOH528
D	PHE213

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO C 302

Chain	Residue
C	ILE73
C	VAL76
C	ARG77
C	CYS78
C	GLU111
C	ILE112

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO C 303

Chain	Residue
C	TYR30
C	CYS43
C	ARG48

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO D 301

Chain	Residue
C	PHE213
D	SER131
D	GLY194
D	ASN198
D	ARG201
D	HOH477
D	HOH478

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO D 302

Chain	Residue
D	ILE73
D	VAL76
D	ARG77
D	CYS78
D	GLU111
D	ILE112

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO D 303

Chain	Residue
D	TRP132
D	SER134
D	SER137
D	VAL226
D	LEU227

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO D 304

Chain	Residue
D	CYS64
D	ASN80
D	HIS110
D	ASP117
D	HOH508

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO E 301

Chain	Residue
E	SER131
E	GLY194
E	ASN198
E	ARG201
E	HOH555
F	PHE213

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO E 302

Chain	Residue
E	ILE73
E	VAL76
E	ARG77
E	CYS78
E	GLU111
E	ILE112

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO E 303

Chain	Residue
E	TYR30
E	CYS43
E	ARG48
E	HOH541

site_id	BC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO F 301

Chain	Residue
E	PHE213
F	SER131
F	GLY194
F	ASN198
F	ARG201
F	HOH468
F	HOH491

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO F 302

Chain	Residue
F	GLU111
F	ILE112
F	ILE73
F	VAL76
F	ARG77
F	CYS78

site_id	CC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO F 303

Chain	Residue
F	GLY160
F	TYR162

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO G 301

Chain	Residue
G	ILE73
G	VAL76
G	ARG77
G	CYS78
G	ILE112

site_id	CC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO G 302

Chain	Residue
G	CYS43
G	ARG48
G	TYR56
G	HOH446

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO H 301

Chain	Residue
H	ILE73
H	VAL76
H	ARG77
H	CYS78
H	GLU111
H	ILE112

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"28665588","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	104
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28665588","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5VYQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)