4PZU
Crystal structure of a putative uncharacterize protein Rv3404c and likely sugar N-formyltransferase from Mycobacterium tuberculosis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004479 | molecular_function | methionyl-tRNA formyltransferase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006413 | biological_process | translational initiation |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016742 | molecular_function | hydroxymethyl-, formyl- and related transferase activity |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0071951 | biological_process | conversion of methionyl-tRNA to N-formyl-methionyl-tRNA |
| B | 0004479 | molecular_function | methionyl-tRNA formyltransferase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006413 | biological_process | translational initiation |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016742 | molecular_function | hydroxymethyl-, formyl- and related transferase activity |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0071951 | biological_process | conversion of methionyl-tRNA to N-formyl-methionyl-tRNA |
| C | 0004479 | molecular_function | methionyl-tRNA formyltransferase activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0006413 | biological_process | translational initiation |
| C | 0009058 | biological_process | biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016742 | molecular_function | hydroxymethyl-, formyl- and related transferase activity |
| C | 0042803 | molecular_function | protein homodimerization activity |
| C | 0071951 | biological_process | conversion of methionyl-tRNA to N-formyl-methionyl-tRNA |
| D | 0004479 | molecular_function | methionyl-tRNA formyltransferase activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0006413 | biological_process | translational initiation |
| D | 0009058 | biological_process | biosynthetic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016742 | molecular_function | hydroxymethyl-, formyl- and related transferase activity |
| D | 0042803 | molecular_function | protein homodimerization activity |
| D | 0071951 | biological_process | conversion of methionyl-tRNA to N-formyl-methionyl-tRNA |
| E | 0004479 | molecular_function | methionyl-tRNA formyltransferase activity |
| E | 0005829 | cellular_component | cytosol |
| E | 0006413 | biological_process | translational initiation |
| E | 0009058 | biological_process | biosynthetic process |
| E | 0016740 | molecular_function | transferase activity |
| E | 0016742 | molecular_function | hydroxymethyl-, formyl- and related transferase activity |
| E | 0042803 | molecular_function | protein homodimerization activity |
| E | 0071951 | biological_process | conversion of methionyl-tRNA to N-formyl-methionyl-tRNA |
| F | 0004479 | molecular_function | methionyl-tRNA formyltransferase activity |
| F | 0005829 | cellular_component | cytosol |
| F | 0006413 | biological_process | translational initiation |
| F | 0009058 | biological_process | biosynthetic process |
| F | 0016740 | molecular_function | transferase activity |
| F | 0016742 | molecular_function | hydroxymethyl-, formyl- and related transferase activity |
| F | 0042803 | molecular_function | protein homodimerization activity |
| F | 0071951 | biological_process | conversion of methionyl-tRNA to N-formyl-methionyl-tRNA |
| G | 0004479 | molecular_function | methionyl-tRNA formyltransferase activity |
| G | 0005829 | cellular_component | cytosol |
| G | 0006413 | biological_process | translational initiation |
| G | 0009058 | biological_process | biosynthetic process |
| G | 0016740 | molecular_function | transferase activity |
| G | 0016742 | molecular_function | hydroxymethyl-, formyl- and related transferase activity |
| G | 0042803 | molecular_function | protein homodimerization activity |
| G | 0071951 | biological_process | conversion of methionyl-tRNA to N-formyl-methionyl-tRNA |
| H | 0004479 | molecular_function | methionyl-tRNA formyltransferase activity |
| H | 0005829 | cellular_component | cytosol |
| H | 0006413 | biological_process | translational initiation |
| H | 0009058 | biological_process | biosynthetic process |
| H | 0016740 | molecular_function | transferase activity |
| H | 0016742 | molecular_function | hydroxymethyl-, formyl- and related transferase activity |
| H | 0042803 | molecular_function | protein homodimerization activity |
| H | 0071951 | biological_process | conversion of methionyl-tRNA to N-formyl-methionyl-tRNA |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 301 |
| Chain | Residue |
| A | SER131 |
| A | GLY194 |
| A | ASN198 |
| A | ARG201 |
| A | HOH465 |
| A | HOH551 |
| B | PHE213 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 302 |
| Chain | Residue |
| A | ARG77 |
| A | CYS78 |
| A | GLU111 |
| A | ILE112 |
| A | ILE73 |
| A | VAL76 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 303 |
| Chain | Residue |
| A | TYR30 |
| A | CYS43 |
| A | ARG48 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 301 |
| Chain | Residue |
| A | PHE213 |
| B | SER131 |
| B | GLY194 |
| B | ASN198 |
| B | ARG201 |
| B | HOH473 |
| B | HOH528 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 302 |
| Chain | Residue |
| B | ILE73 |
| B | VAL76 |
| B | ARG77 |
| B | CYS78 |
| B | GLU111 |
| B | ILE112 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 303 |
| Chain | Residue |
| B | TYR30 |
| B | CYS43 |
| B | ARG48 |
| B | HOH515 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO C 301 |
| Chain | Residue |
| C | SER131 |
| C | GLY194 |
| C | ASN198 |
| C | ARG201 |
| C | HOH527 |
| C | HOH528 |
| D | PHE213 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO C 302 |
| Chain | Residue |
| C | ILE73 |
| C | VAL76 |
| C | ARG77 |
| C | CYS78 |
| C | GLU111 |
| C | ILE112 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO C 303 |
| Chain | Residue |
| C | TYR30 |
| C | CYS43 |
| C | ARG48 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO D 301 |
| Chain | Residue |
| C | PHE213 |
| D | SER131 |
| D | GLY194 |
| D | ASN198 |
| D | ARG201 |
| D | HOH477 |
| D | HOH478 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO D 302 |
| Chain | Residue |
| D | ILE73 |
| D | VAL76 |
| D | ARG77 |
| D | CYS78 |
| D | GLU111 |
| D | ILE112 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO D 303 |
| Chain | Residue |
| D | TRP132 |
| D | SER134 |
| D | SER137 |
| D | VAL226 |
| D | LEU227 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO D 304 |
| Chain | Residue |
| D | CYS64 |
| D | ASN80 |
| D | HIS110 |
| D | ASP117 |
| D | HOH508 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO E 301 |
| Chain | Residue |
| E | SER131 |
| E | GLY194 |
| E | ASN198 |
| E | ARG201 |
| E | HOH555 |
| F | PHE213 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO E 302 |
| Chain | Residue |
| E | ILE73 |
| E | VAL76 |
| E | ARG77 |
| E | CYS78 |
| E | GLU111 |
| E | ILE112 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO E 303 |
| Chain | Residue |
| E | TYR30 |
| E | CYS43 |
| E | ARG48 |
| E | HOH541 |
| site_id | BC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO F 301 |
| Chain | Residue |
| E | PHE213 |
| F | SER131 |
| F | GLY194 |
| F | ASN198 |
| F | ARG201 |
| F | HOH468 |
| F | HOH491 |
| site_id | BC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO F 302 |
| Chain | Residue |
| F | GLU111 |
| F | ILE112 |
| F | ILE73 |
| F | VAL76 |
| F | ARG77 |
| F | CYS78 |
| site_id | CC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO F 303 |
| Chain | Residue |
| F | GLY160 |
| F | TYR162 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO G 301 |
| Chain | Residue |
| G | ILE73 |
| G | VAL76 |
| G | ARG77 |
| G | CYS78 |
| G | ILE112 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO G 302 |
| Chain | Residue |
| G | CYS43 |
| G | ARG48 |
| G | TYR56 |
| G | HOH446 |
| site_id | CC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO H 301 |
| Chain | Residue |
| H | ILE73 |
| H | VAL76 |
| H | ARG77 |
| H | CYS78 |
| H | GLU111 |
| H | ILE112 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | ACT_SITE: Proton acceptor => ECO:0000305|PubMed:28665588 |
| Chain | Residue | Details |
| A | VAL81 | |
| B | VAL81 | |
| C | VAL81 | |
| D | VAL81 | |
| E | VAL81 | |
| F | VAL81 | |
| G | VAL81 | |
| H | VAL81 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 64 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:28665588, ECO:0007744|PDB:5VYQ |
| Chain | Residue | Details |
| A | ASP9 | |
| B | PHE62 | |
| B | LYS65 | |
| B | ARG90 | |
| B | ILE112 | |
| B | LEU116 | |
| B | LEU175 | |
| B | ARG209 | |
| C | ASP9 | |
| C | PHE62 | |
| C | LYS65 | |
| A | PHE62 | |
| C | ARG90 | |
| C | ILE112 | |
| C | LEU116 | |
| C | LEU175 | |
| C | ARG209 | |
| D | ASP9 | |
| D | PHE62 | |
| D | LYS65 | |
| D | ARG90 | |
| D | ILE112 | |
| A | LYS65 | |
| D | LEU116 | |
| D | LEU175 | |
| D | ARG209 | |
| E | ASP9 | |
| E | PHE62 | |
| E | LYS65 | |
| E | ARG90 | |
| E | ILE112 | |
| E | LEU116 | |
| E | LEU175 | |
| A | ARG90 | |
| E | ARG209 | |
| F | ASP9 | |
| F | PHE62 | |
| F | LYS65 | |
| F | ARG90 | |
| F | ILE112 | |
| F | LEU116 | |
| F | LEU175 | |
| F | ARG209 | |
| G | ASP9 | |
| A | ILE112 | |
| G | PHE62 | |
| G | LYS65 | |
| G | ARG90 | |
| G | ILE112 | |
| G | LEU116 | |
| G | LEU175 | |
| G | ARG209 | |
| H | ASP9 | |
| H | PHE62 | |
| H | LYS65 | |
| A | LEU116 | |
| H | ARG90 | |
| H | ILE112 | |
| H | LEU116 | |
| H | LEU175 | |
| H | ARG209 | |
| A | LEU175 | |
| A | ARG209 | |
| B | ASP9 |
