4PYG

Transglutaminase2 complexed with GTP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000785	cellular_component	chromatin
A	0000786	cellular_component	nucleosome
A	0003810	molecular_function	protein-glutamine gamma-glutamyltransferase activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005634	cellular_component	nucleus
A	0005694	cellular_component	chromosome
A	0005739	cellular_component	mitochondrion
A	0005783	cellular_component	endoplasmic reticulum
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0005925	cellular_component	focal adhesion
A	0006338	biological_process	chromatin remodeling
A	0006508	biological_process	proteolysis
A	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
A	0008233	molecular_function	peptidase activity
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0016787	molecular_function	hydrolase activity
A	0018149	biological_process	peptide cross-linking
A	0018277	biological_process	protein deamination
A	0031012	cellular_component	extracellular matrix
A	0032471	biological_process	negative regulation of endoplasmic reticulum calcium ion concentration
A	0042981	biological_process	regulation of apoptotic process
A	0043065	biological_process	positive regulation of apoptotic process
A	0043277	biological_process	apoptotic cell clearance
A	0043547	biological_process	positive regulation of GTPase activity
A	0045785	biological_process	positive regulation of cell adhesion
A	0046872	molecular_function	metal ion binding
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0050568	molecular_function	protein-glutamine glutaminase activity
A	0050769	biological_process	positive regulation of neurogenesis
A	0051057	biological_process	positive regulation of small GTPase mediated signal transduction
A	0051561	biological_process	positive regulation of mitochondrial calcium ion concentration
A	0060348	biological_process	bone development
A	0070062	cellular_component	extracellular exosome
A	0071314	biological_process	cellular response to cocaine
A	0120294	molecular_function	peptide serotonyltransferase activity
A	0120295	molecular_function	histone serotonyltransferase activity
A	0120296	molecular_function	peptide dopaminyltransferase activity
A	0120297	molecular_function	histone dopaminyltransferase activity
A	0120298	molecular_function	peptide noradrenalinyltransferase activity
A	0120299	molecular_function	peptide histaminyltransferase activity
A	1903351	biological_process	cellular response to dopamine
A	1903672	biological_process	positive regulation of sprouting angiogenesis
A	1904015	biological_process	cellular response to serotonin
A	2000425	biological_process	regulation of apoptotic cell clearance
B	0000166	molecular_function	nucleotide binding
B	0000785	cellular_component	chromatin
B	0000786	cellular_component	nucleosome
B	0003810	molecular_function	protein-glutamine gamma-glutamyltransferase activity
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005634	cellular_component	nucleus
B	0005694	cellular_component	chromosome
B	0005739	cellular_component	mitochondrion
B	0005783	cellular_component	endoplasmic reticulum
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005925	cellular_component	focal adhesion
B	0006338	biological_process	chromatin remodeling
B	0006508	biological_process	proteolysis
B	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
B	0008233	molecular_function	peptidase activity
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0016787	molecular_function	hydrolase activity
B	0018149	biological_process	peptide cross-linking
B	0018277	biological_process	protein deamination
B	0031012	cellular_component	extracellular matrix
B	0032471	biological_process	negative regulation of endoplasmic reticulum calcium ion concentration
B	0042981	biological_process	regulation of apoptotic process
B	0043065	biological_process	positive regulation of apoptotic process
B	0043277	biological_process	apoptotic cell clearance
B	0043547	biological_process	positive regulation of GTPase activity
B	0045785	biological_process	positive regulation of cell adhesion
B	0046872	molecular_function	metal ion binding
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0050568	molecular_function	protein-glutamine glutaminase activity
B	0050769	biological_process	positive regulation of neurogenesis
B	0051057	biological_process	positive regulation of small GTPase mediated signal transduction
B	0051561	biological_process	positive regulation of mitochondrial calcium ion concentration
B	0060348	biological_process	bone development
B	0070062	cellular_component	extracellular exosome
B	0071314	biological_process	cellular response to cocaine
B	0120294	molecular_function	peptide serotonyltransferase activity
B	0120295	molecular_function	histone serotonyltransferase activity
B	0120296	molecular_function	peptide dopaminyltransferase activity
B	0120297	molecular_function	histone dopaminyltransferase activity
B	0120298	molecular_function	peptide noradrenalinyltransferase activity
B	0120299	molecular_function	peptide histaminyltransferase activity
B	1903351	biological_process	cellular response to dopamine
B	1903672	biological_process	positive regulation of sprouting angiogenesis
B	1904015	biological_process	cellular response to serotonin
B	2000425	biological_process	regulation of apoptotic cell clearance
E	0000166	molecular_function	nucleotide binding
E	0000785	cellular_component	chromatin
E	0000786	cellular_component	nucleosome
E	0003810	molecular_function	protein-glutamine gamma-glutamyltransferase activity
E	0005509	molecular_function	calcium ion binding
E	0005515	molecular_function	protein binding
E	0005525	molecular_function	GTP binding
E	0005634	cellular_component	nucleus
E	0005694	cellular_component	chromosome
E	0005739	cellular_component	mitochondrion
E	0005783	cellular_component	endoplasmic reticulum
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0005925	cellular_component	focal adhesion
E	0006338	biological_process	chromatin remodeling
E	0006508	biological_process	proteolysis
E	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
E	0008233	molecular_function	peptidase activity
E	0016740	molecular_function	transferase activity
E	0016746	molecular_function	acyltransferase activity
E	0016787	molecular_function	hydrolase activity
E	0018149	biological_process	peptide cross-linking
E	0018277	biological_process	protein deamination
E	0031012	cellular_component	extracellular matrix
E	0032471	biological_process	negative regulation of endoplasmic reticulum calcium ion concentration
E	0042981	biological_process	regulation of apoptotic process
E	0043065	biological_process	positive regulation of apoptotic process
E	0043277	biological_process	apoptotic cell clearance
E	0043547	biological_process	positive regulation of GTPase activity
E	0045785	biological_process	positive regulation of cell adhesion
E	0046872	molecular_function	metal ion binding
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0050568	molecular_function	protein-glutamine glutaminase activity
E	0050769	biological_process	positive regulation of neurogenesis
E	0051057	biological_process	positive regulation of small GTPase mediated signal transduction
E	0051561	biological_process	positive regulation of mitochondrial calcium ion concentration
E	0060348	biological_process	bone development
E	0070062	cellular_component	extracellular exosome
E	0071314	biological_process	cellular response to cocaine
E	0120294	molecular_function	peptide serotonyltransferase activity
E	0120295	molecular_function	histone serotonyltransferase activity
E	0120296	molecular_function	peptide dopaminyltransferase activity
E	0120297	molecular_function	histone dopaminyltransferase activity
E	0120298	molecular_function	peptide noradrenalinyltransferase activity
E	0120299	molecular_function	peptide histaminyltransferase activity
E	1903351	biological_process	cellular response to dopamine
E	1903672	biological_process	positive regulation of sprouting angiogenesis
E	1904015	biological_process	cellular response to serotonin
E	2000425	biological_process	regulation of apoptotic cell clearance

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE GTP A 701

Chain	Residue
A	LYS173
A	MET483
A	ARG580
A	LEU582
A	TYR583
A	HOH802
A	HOH808
A	HOH808
A	PHE174
A	ARG476
A	ARG478
A	ARG478
A	VAL479
A	GLY480
A	GLN481
A	SER482

---

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GTP B 701

Chain	Residue
B	PHE174
B	ARG476
B	ARG478
B	VAL479
B	GLY480
B	GLN481
B	SER482
B	MET483
B	ARG580
B	LEU582
B	TYR583
E	ARG478
E	GTP701

---

site_id	AC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE GTP E 701

Chain	Residue
B	GTP701
E	PHE174
E	ARG476
E	ILE477
E	ARG478
E	VAL479
E	GLY480
E	GLN481
E	SER482
E	MET483
E	ARG580
E	LEU582
E	TYR583
E	HOH808

---

Functional Information from PROSITE/UniProt

site_id	PS00547
Number of Residues	18
Details	TRANSGLUTAMINASES Transglutaminases active site. GQCWVfAAVacTvLRCLG

Chain	Residue	Details
A	GLY275-GLY292

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10024","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"7649299","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"8943303","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10024","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P00488","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31991788","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	30
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25192068","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30321187","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31991788","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11867708","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"20450932","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1KV3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LY6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PYG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6A8P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KZB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	Site: {"description":"Important for catalytic activity","evidences":[{"source":"UniProtKB","id":"P52181","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	3
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P21981","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	6
Details	Cross-link: {"description":"Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-?)","evidences":[{"source":"UniProtKB","id":"P08587","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---