4PX9
DEAD-box RNA helicase DDX3X Domain 1 with N-terminal ATP-binding Loop
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003724 | molecular_function | RNA helicase activity |
| A | 0005524 | molecular_function | ATP binding |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0003724 | molecular_function | RNA helicase activity |
| B | 0005524 | molecular_function | ATP binding |
| C | 0003676 | molecular_function | nucleic acid binding |
| C | 0003724 | molecular_function | RNA helicase activity |
| C | 0005524 | molecular_function | ATP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ADP A 601 |
| Chain | Residue |
| A | TYR200 |
| A | ARG202 |
| A | GLN207 |
| A | THR226 |
| A | GLY227 |
| A | GLY229 |
| A | LYS230 |
| A | THR231 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE ADP B 501 |
| Chain | Residue |
| B | ARG202 |
| B | GLN207 |
| B | THR226 |
| B | GLY227 |
| B | SER228 |
| B | GLY229 |
| B | LYS230 |
| B | THR231 |
| B | TYR200 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE ADP C 501 |
| Chain | Residue |
| C | THR156 |
| C | ILE158 |
| C | PHE182 |
| C | TYR200 |
| C | ARG202 |
| C | GLN207 |
| C | THR226 |
| C | GLY227 |
| C | GLY229 |
| C | LYS230 |
| C | THR231 |
Functional Information from PROSITE/UniProt
| site_id | PS00039 |
| Number of Residues | 9 |
| Details | DEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. VLDEADRmL |
| Chain | Residue | Details |
| A | VAL345-LEU353 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 576 |
| Details | Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 27 |
| Details | Region: {"description":"Involved in stimulation of ATPase activity by DNA and RNA, nucleic acid binding and unwinding and HIV-1 replication"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 84 |
| Details | Motif: {"description":"Q motif"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 9 |
| Details | Motif: {"description":"DEAD box"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 42 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 9 |
| Details | Modified residue: {"description":"Phosphoserine; by TBK1; in vitro","evidences":[{"source":"PubMed","id":"18583960","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Phosphoserine; by TBK1","evidences":[{"source":"PubMed","id":"18583960","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 33 |
| Details | Region: {"description":"Interaction with CHUK","evidences":[{"source":"PubMed","id":"17667941","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
