4PW8

Human tryptophan 2,3-dioxygenase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004833	molecular_function	tryptophan 2,3-dioxygenase activity
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0006568	biological_process	tryptophan metabolic process
A	0006569	biological_process	tryptophan catabolic process
A	0016597	molecular_function	amino acid binding
A	0019441	biological_process	tryptophan catabolic process to kynurenine
A	0019442	biological_process	tryptophan catabolic process to acetyl-CoA
A	0019825	molecular_function	oxygen binding
A	0020037	molecular_function	heme binding
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0051213	molecular_function	dioxygenase activity
A	0051289	biological_process	protein homotetramerization
A	1904842	biological_process	response to nitroglycerin
B	0004833	molecular_function	tryptophan 2,3-dioxygenase activity
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0006568	biological_process	tryptophan metabolic process
B	0006569	biological_process	tryptophan catabolic process
B	0016597	molecular_function	amino acid binding
B	0019441	biological_process	tryptophan catabolic process to kynurenine
B	0019442	biological_process	tryptophan catabolic process to acetyl-CoA
B	0019825	molecular_function	oxygen binding
B	0020037	molecular_function	heme binding
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0051213	molecular_function	dioxygenase activity
B	0051289	biological_process	protein homotetramerization
B	1904842	biological_process	response to nitroglycerin
C	0004833	molecular_function	tryptophan 2,3-dioxygenase activity
C	0005515	molecular_function	protein binding
C	0005829	cellular_component	cytosol
C	0006568	biological_process	tryptophan metabolic process
C	0006569	biological_process	tryptophan catabolic process
C	0016597	molecular_function	amino acid binding
C	0019441	biological_process	tryptophan catabolic process to kynurenine
C	0019442	biological_process	tryptophan catabolic process to acetyl-CoA
C	0019825	molecular_function	oxygen binding
C	0020037	molecular_function	heme binding
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0051213	molecular_function	dioxygenase activity
C	0051289	biological_process	protein homotetramerization
C	1904842	biological_process	response to nitroglycerin
D	0004833	molecular_function	tryptophan 2,3-dioxygenase activity
D	0005515	molecular_function	protein binding
D	0005829	cellular_component	cytosol
D	0006568	biological_process	tryptophan metabolic process
D	0006569	biological_process	tryptophan catabolic process
D	0016597	molecular_function	amino acid binding
D	0019441	biological_process	tryptophan catabolic process to kynurenine
D	0019442	biological_process	tryptophan catabolic process to acetyl-CoA
D	0019825	molecular_function	oxygen binding
D	0020037	molecular_function	heme binding
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
D	0051213	molecular_function	dioxygenase activity
D	0051289	biological_process	protein homotetramerization
D	1904842	biological_process	response to nitroglycerin
E	0004833	molecular_function	tryptophan 2,3-dioxygenase activity
E	0005515	molecular_function	protein binding
E	0005829	cellular_component	cytosol
E	0006568	biological_process	tryptophan metabolic process
E	0006569	biological_process	tryptophan catabolic process
E	0016597	molecular_function	amino acid binding
E	0019441	biological_process	tryptophan catabolic process to kynurenine
E	0019442	biological_process	tryptophan catabolic process to acetyl-CoA
E	0019825	molecular_function	oxygen binding
E	0020037	molecular_function	heme binding
E	0042802	molecular_function	identical protein binding
E	0046872	molecular_function	metal ion binding
E	0051213	molecular_function	dioxygenase activity
E	0051289	biological_process	protein homotetramerization
E	1904842	biological_process	response to nitroglycerin
F	0004833	molecular_function	tryptophan 2,3-dioxygenase activity
F	0005515	molecular_function	protein binding
F	0005829	cellular_component	cytosol
F	0006568	biological_process	tryptophan metabolic process
F	0006569	biological_process	tryptophan catabolic process
F	0016597	molecular_function	amino acid binding
F	0019441	biological_process	tryptophan catabolic process to kynurenine
F	0019442	biological_process	tryptophan catabolic process to acetyl-CoA
F	0019825	molecular_function	oxygen binding
F	0020037	molecular_function	heme binding
F	0042802	molecular_function	identical protein binding
F	0046872	molecular_function	metal ion binding
F	0051213	molecular_function	dioxygenase activity
F	0051289	biological_process	protein homotetramerization
F	1904842	biological_process	response to nitroglycerin
G	0004833	molecular_function	tryptophan 2,3-dioxygenase activity
G	0005515	molecular_function	protein binding
G	0005829	cellular_component	cytosol
G	0006568	biological_process	tryptophan metabolic process
G	0006569	biological_process	tryptophan catabolic process
G	0016597	molecular_function	amino acid binding
G	0019441	biological_process	tryptophan catabolic process to kynurenine
G	0019442	biological_process	tryptophan catabolic process to acetyl-CoA
G	0019825	molecular_function	oxygen binding
G	0020037	molecular_function	heme binding
G	0042802	molecular_function	identical protein binding
G	0046872	molecular_function	metal ion binding
G	0051213	molecular_function	dioxygenase activity
G	0051289	biological_process	protein homotetramerization
G	1904842	biological_process	response to nitroglycerin
H	0004833	molecular_function	tryptophan 2,3-dioxygenase activity
H	0005515	molecular_function	protein binding
H	0005829	cellular_component	cytosol
H	0006568	biological_process	tryptophan metabolic process
H	0006569	biological_process	tryptophan catabolic process
H	0016597	molecular_function	amino acid binding
H	0019441	biological_process	tryptophan catabolic process to kynurenine
H	0019442	biological_process	tryptophan catabolic process to acetyl-CoA
H	0019825	molecular_function	oxygen binding
H	0020037	molecular_function	heme binding
H	0042802	molecular_function	identical protein binding
H	0046872	molecular_function	metal ion binding
H	0051213	molecular_function	dioxygenase activity
H	0051289	biological_process	protein homotetramerization
H	1904842	biological_process	response to nitroglycerin

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CO H 401

Chain	Residue
H	GLU203

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03020, ECO:0000269|PubMed:27762317, ECO:0007744|PDB:5TI9

Chain	Residue	Details
A	PHE72
D	PHE72
D	ARG144
D	THR342
E	PHE72
E	ARG144
E	THR342
F	PHE72
F	ARG144
F	THR342
G	PHE72
A	ARG144
G	ARG144
G	THR342
H	PHE72
H	ARG144
H	THR342
A	THR342
B	PHE72
B	ARG144
B	THR342
C	PHE72
C	ARG144
C	THR342

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site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: axial binding residue => ECO:0000255|HAMAP-Rule:MF_03020, ECO:0000269|PubMed:27762317, ECO:0007744|PDB:5TI9

Chain	Residue	Details
A	HIS328
B	HIS328
C	HIS328
D	HIS328
E	HIS328
F	HIS328
G	HIS328
H	HIS328

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