Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4PVD

Crystal structure of yeast methylglyoxal/isovaleraldehyde reductase Gre2 complexed with NADPH

Functional Information from GO Data
ChainGOidnamespacecontents
A0003854molecular_function3-beta-hydroxy-delta5-steroid dehydrogenase activity
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0006694biological_processsteroid biosynthetic process
A0008204biological_processergosterol metabolic process
A0016491molecular_functionoxidoreductase activity
A0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A0030447biological_processfilamentous growth
A0043892molecular_functionmethylglyoxal reductase (NADPH) activity
A0046568molecular_function3-methylbutanal reductase [NAD(P)H] activity
A0052675molecular_function3-methylbutanal reductase (NADPH) activity
A0052676molecular_function3-methylbutanal reductase (NADH) activity
B0003854molecular_function3-beta-hydroxy-delta5-steroid dehydrogenase activity
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0006694biological_processsteroid biosynthetic process
B0008204biological_processergosterol metabolic process
B0016491molecular_functionoxidoreductase activity
B0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B0030447biological_processfilamentous growth
B0043892molecular_functionmethylglyoxal reductase (NADPH) activity
B0046568molecular_function3-methylbutanal reductase [NAD(P)H] activity
B0052675molecular_function3-methylbutanal reductase (NADPH) activity
B0052676molecular_function3-methylbutanal reductase (NADH) activity
C0003854molecular_function3-beta-hydroxy-delta5-steroid dehydrogenase activity
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0006694biological_processsteroid biosynthetic process
C0008204biological_processergosterol metabolic process
C0016491molecular_functionoxidoreductase activity
C0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C0030447biological_processfilamentous growth
C0043892molecular_functionmethylglyoxal reductase (NADPH) activity
C0046568molecular_function3-methylbutanal reductase [NAD(P)H] activity
C0052675molecular_function3-methylbutanal reductase (NADPH) activity
C0052676molecular_function3-methylbutanal reductase (NADH) activity
D0003854molecular_function3-beta-hydroxy-delta5-steroid dehydrogenase activity
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0006694biological_processsteroid biosynthetic process
D0008204biological_processergosterol metabolic process
D0016491molecular_functionoxidoreductase activity
D0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D0030447biological_processfilamentous growth
D0043892molecular_functionmethylglyoxal reductase (NADPH) activity
D0046568molecular_function3-methylbutanal reductase [NAD(P)H] activity
D0052675molecular_function3-methylbutanal reductase (NADPH) activity
D0052676molecular_function3-methylbutanal reductase (NADH) activity
Functional Information from PDB Data
site_idAC1
Number of Residues25
DetailsBINDING SITE FOR RESIDUE NDP A 401
ChainResidue
AGLY7
ATHR81
AALA82
ASER83
APRO84
APHE85
ATHR125
ASER126
ASER127
ATYR165
ALYS169
AASN9
APRO196
AVAL197
ATYR198
AVAL199
ASER216
AHOH532
AGLY10
APHE11
AILE12
AARG32
ALYS36
AASP57
AILE58

site_idAC2
Number of Residues26
DetailsBINDING SITE FOR RESIDUE NDP B 401
ChainResidue
BGLY7
BASN9
BGLY10
BPHE11
BILE12
BARG32
BLYS36
BASP57
BILE58
BTHR81
BALA82
BSER83
BPRO84
BPHE85
BTHR125
BSER126
BSER127
BTYR165
BLYS169
BPRO196
BVAL197
BTYR198
BVAL199
BSER216
BHOH511
BHOH513

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Proton donor => ECO:0000305|PubMed:24879127
ChainResidueDetails
ALYS169
BLYS169
CLYS169
DLYS169

site_idSWS_FT_FI2
Number of Residues32
DetailsBINDING: BINDING => ECO:0000269|PubMed:24879127
ChainResidueDetails
ATYR165
ALYS169
AVAL199
ASER216
BGLY7
BARG32
BLYS36
BASP57
BTYR165
BLYS169
BVAL199
BSER216
CGLY7
CARG32
CLYS36
CASP57
CTYR165
CLYS169
CVAL199
CSER216
DGLY7
DARG32
DLYS36
DASP57
DTYR165
DLYS169
DVAL199
DSER216
AGLY7
AARG32
ALYS36
AASP57

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956
ChainResidueDetails
DSER333
ASER333
BSER333
CSER333

221051

PDB entries from 2024-06-12

PDB statisticsPDBj update infoContact PDBjnumon