4PVD

Crystal structure of yeast methylglyoxal/isovaleraldehyde reductase Gre2 complexed with NADPH

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006694	biological_process	steroid biosynthetic process
A	0008204	biological_process	ergosterol metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0030447	biological_process	filamentous growth
A	0043892	molecular_function	methylglyoxal reductase (NADPH) activity
A	0046568	molecular_function	3-methylbutanal reductase [NAD(P)H] activity
A	0052675	molecular_function	3-methylbutanal reductase (NADPH) activity
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0006694	biological_process	steroid biosynthetic process
B	0008204	biological_process	ergosterol metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0030447	biological_process	filamentous growth
B	0043892	molecular_function	methylglyoxal reductase (NADPH) activity
B	0046568	molecular_function	3-methylbutanal reductase [NAD(P)H] activity
B	0052675	molecular_function	3-methylbutanal reductase (NADPH) activity
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0006694	biological_process	steroid biosynthetic process
C	0008204	biological_process	ergosterol metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0030447	biological_process	filamentous growth
C	0043892	molecular_function	methylglyoxal reductase (NADPH) activity
C	0046568	molecular_function	3-methylbutanal reductase [NAD(P)H] activity
C	0052675	molecular_function	3-methylbutanal reductase (NADPH) activity
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0006694	biological_process	steroid biosynthetic process
D	0008204	biological_process	ergosterol metabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0030447	biological_process	filamentous growth
D	0043892	molecular_function	methylglyoxal reductase (NADPH) activity
D	0046568	molecular_function	3-methylbutanal reductase [NAD(P)H] activity
D	0052675	molecular_function	3-methylbutanal reductase (NADPH) activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	25
Details	BINDING SITE FOR RESIDUE NDP A 401

Chain	Residue
A	GLY7
A	THR81
A	ALA82
A	SER83
A	PRO84
A	PHE85
A	THR125
A	SER126
A	SER127
A	TYR165
A	LYS169
A	ASN9
A	PRO196
A	VAL197
A	TYR198
A	VAL199
A	SER216
A	HOH532
A	GLY10
A	PHE11
A	ILE12
A	ARG32
A	LYS36
A	ASP57
A	ILE58

---

site_id	AC2
Number of Residues	26
Details	BINDING SITE FOR RESIDUE NDP B 401

Chain	Residue
B	GLY7
B	ASN9
B	GLY10
B	PHE11
B	ILE12
B	ARG32
B	LYS36
B	ASP57
B	ILE58
B	THR81
B	ALA82
B	SER83
B	PRO84
B	PHE85
B	THR125
B	SER126
B	SER127
B	TYR165
B	LYS169
B	PRO196
B	VAL197
B	TYR198
B	VAL199
B	SER216
B	HOH511
B	HOH513

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"24879127","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	44
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24879127","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---