4PU9

E. coli GyrB 43-kDa N-terminal fragment in complex with ADP-BeF3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
A	0005524	molecular_function	ATP binding
A	0006265	biological_process	DNA topological change

Functional Information from PDB Data

site_id	AC1
Number of Residues	25
Details	BINDING SITE FOR RESIDUE ADP A 401

Chain	Residue
A	TYR5
A	LYS103
A	TYR109
A	GLY114
A	LEU115
A	HIS116
A	GLY117
A	VAL118
A	GLY119
A	VAL120
A	SER121
A	ILE10
A	THR165
A	BEF402
A	MG403
A	HOH501
A	HOH502
A	HOH506
A	ASN46
A	GLU50
A	ASP73
A	ILE78
A	ILE94
A	ALA100
A	GLY102

---

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE BEF A 402

Chain	Residue
A	GLY114
A	LEU115
A	HIS116
A	GLY117
A	VAL118
A	GLY119
A	LYS337
A	ADP401
A	MG403
A	HOH507
A	HOH547
A	HOH548

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 403

Chain	Residue
A	ASN46
A	ADP401
A	BEF402
A	HOH507

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor (ATPase activity)","evidences":[{"source":"PubMed","id":"10734094","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"8248233","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25202966","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25849408","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10734094","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10734094","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25202966","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25849408","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25849408","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10734094","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25849408","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"PubMed","id":"9657678","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---