4PS4

Crystal structure of the complex between IL-13 and M1295 FAB

Replaces:  3L5Y

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001774	biological_process	microglial cell activation
A	0002639	biological_process	positive regulation of immunoglobulin production
A	0005125	molecular_function	cytokine activity
A	0005126	molecular_function	cytokine receptor binding
A	0005144	molecular_function	interleukin-13 receptor binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0005898	cellular_component	interleukin-13 receptor complex
A	0006915	biological_process	apoptotic process
A	0006954	biological_process	inflammatory response
A	0006955	biological_process	immune response
A	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
A	0009612	biological_process	response to mechanical stimulus
A	0009897	cellular_component	external side of plasma membrane
A	0010155	biological_process	regulation of proton transport
A	0010628	biological_process	positive regulation of gene expression
A	0030890	biological_process	positive regulation of B cell proliferation
A	0032496	biological_process	response to lipopolysaccharide
A	0032733	biological_process	positive regulation of interleukin-10 production
A	0032905	biological_process	transforming growth factor beta1 production
A	0032908	biological_process	regulation of transforming growth factor beta1 production
A	0035094	biological_process	response to nicotine
A	0035772	biological_process	interleukin-13-mediated signaling pathway
A	0042116	biological_process	macrophage activation
A	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
A	0043032	biological_process	positive regulation of macrophage activation
A	0043235	cellular_component	receptor complex
A	0043270	biological_process	positive regulation of monoatomic ion transport
A	0045471	biological_process	response to ethanol
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0048661	biological_process	positive regulation of smooth muscle cell proliferation
A	0050714	biological_process	positive regulation of protein secretion
A	0050728	biological_process	negative regulation of inflammatory response
A	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
A	0070371	biological_process	ERK1 and ERK2 cascade
A	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
A	0071260	biological_process	cellular response to mechanical stimulus
A	0071635	biological_process	negative regulation of transforming growth factor beta production
A	0120162	biological_process	positive regulation of cold-induced thermogenesis
A	1901247	biological_process	negative regulation of lung ciliated cell differentiation
A	1901251	biological_process	positive regulation of lung goblet cell differentiation
A	1903660	biological_process	negative regulation of complement-dependent cytotoxicity
A	2000231	biological_process	positive regulation of pancreatic stellate cell proliferation
A	2000352	biological_process	negative regulation of endothelial cell apoptotic process

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
H	TYR202-HIS208
L	TYR191-HIS197

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site_id	PS00838
Number of Residues	28
Details	INTERLEUKIN_4_13 Interleukins -4 and -13 signature. LrELIeelvnITqnqkaplCngsmVwSI

Chain	Residue	Details
A	LEU10-ILE37

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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