4PRG
0072 PARTIAL AGONIST PPAR GAMMA COCRYSTAL
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0004879 | molecular_function | nuclear receptor activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0003677 | molecular_function | DNA binding |
| B | 0004879 | molecular_function | nuclear receptor activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0003677 | molecular_function | DNA binding |
| C | 0004879 | molecular_function | nuclear receptor activity |
| C | 0005634 | cellular_component | nucleus |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0003677 | molecular_function | DNA binding |
| D | 0004879 | molecular_function | nuclear receptor activity |
| D | 0005634 | cellular_component | nucleus |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE 072 A 1 |
| Chain | Residue |
| A | LEU255 |
| A | ILE326 |
| A | TYR327 |
| A | MET329 |
| A | LEU340 |
| A | ILE341 |
| A | SER342 |
| A | PHE360 |
| A | PHE363 |
| A | MET364 |
| A | GLU259 |
| A | PHE264 |
| A | HIS266 |
| A | ALA278 |
| A | ARG280 |
| A | ILE281 |
| A | CYS285 |
| A | ARG288 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE 072 B 2 |
| Chain | Residue |
| B | GLU259 |
| B | PHE264 |
| B | ILE267 |
| B | ALA278 |
| B | ARG280 |
| B | ILE281 |
| B | PHE282 |
| B | CYS285 |
| B | ARG288 |
| B | SER289 |
| B | TYR327 |
| B | MET329 |
| B | LEU330 |
| B | LEU340 |
| B | ILE341 |
| B | SER342 |
| B | PHE363 |
| B | MET364 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE 072 C 3 |
| Chain | Residue |
| C | GLU259 |
| C | PHE264 |
| C | HIS266 |
| C | ILE267 |
| C | ALA278 |
| C | ARG280 |
| C | ILE281 |
| C | CYS285 |
| C | ARG288 |
| C | ILE326 |
| C | TYR327 |
| C | MET329 |
| C | LEU330 |
| C | LEU333 |
| C | ILE341 |
| C | SER342 |
| C | PHE360 |
| C | MET364 |
| site_id | AC4 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE 072 D 4 |
| Chain | Residue |
| D | GLU259 |
| D | ILE267 |
| D | THR268 |
| D | PRO269 |
| D | ALA278 |
| D | ARG280 |
| D | ILE281 |
| D | PHE282 |
| D | CYS285 |
| D | ARG288 |
| D | SER289 |
| D | GLU295 |
| D | ILE326 |
| D | TYR327 |
| D | LEU333 |
| D | LEU340 |
| D | LEU353 |
| D | LEU356 |
| D | PHE363 |
| D | MET364 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG |
| Chain | Residue | Details |
| A | THR316 | |
| A | LEU353 | |
| B | THR316 | |
| B | LEU353 | |
| C | THR316 | |
| C | LEU353 | |
| D | THR316 | |
| D | LEU353 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 |
| Chain | Residue | Details |
| A | SER254 | |
| B | SER254 | |
| C | SER254 | |
| D | SER254 |
