4PR9

Human Vinculin (residues 891-1066) in complex with PIP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003779	molecular_function	actin binding
A	0007155	biological_process	cell adhesion
A	0051015	molecular_function	actin filament binding
B	0003779	molecular_function	actin binding
B	0007155	biological_process	cell adhesion
B	0051015	molecular_function	actin filament binding
C	0003779	molecular_function	actin binding
C	0007155	biological_process	cell adhesion
C	0051015	molecular_function	actin filament binding
D	0003779	molecular_function	actin binding
D	0007155	biological_process	cell adhesion
D	0051015	molecular_function	actin filament binding
E	0003779	molecular_function	actin binding
E	0007155	biological_process	cell adhesion
E	0051015	molecular_function	actin filament binding
F	0003779	molecular_function	actin binding
F	0007155	biological_process	cell adhesion
F	0051015	molecular_function	actin filament binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PIO A 1101

Chain	Residue
A	SER914
A	LYS915
A	LYS1061
A	HOH1206
B	LYS915
B	LYS1061

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PIO B 1101

Chain	Residue
C	LYS915
C	GOL1101
D	LYS915
B	LYS944
B	ARG945
B	HOH1218

---

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GOL B 1102

Chain	Residue
B	LYS915

---

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GOL C 1101

Chain	Residue
B	PIO1101

---

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PIO E 1101

Chain	Residue
D	LYS944
D	ARG945
D	THR1004
E	SER913
E	SER914
E	LYS915
E	LYS1061
F	SER914
F	LYS915
F	ARG1057

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	286
Details	Region: {"description":"Facilitates phospholipid membrane insertion","evidences":[{"source":"UniProtKB","id":"Q64727","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Modified residue: {"description":"Phosphotyrosine; by SRC-type Tyr-kinases","evidences":[{"source":"PubMed","id":"15229287","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---