4PP4

Minute virus of mice non-structural protein-1N-terminal nuclease domain reveals a unique Zn2+ coordination in the active site pocket and shows a novel mode of DNA recognition at the origin of replication

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE BME A 301

Chain	Residue
A	VAL25
A	PHE26
A	PHE137
A	SER138
A	GLN139
A	CYS200
A	HOH458

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 302

Chain	Residue
A	SER230
A	SER231
A	HOH409
A	ASP91
A	VAL116

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA A 303

Chain	Residue
A	LYS49
A	GLU50
A	LEU51
A	HOH401

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NA A 304

Chain	Residue
A	THR83
A	SER220

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: For nuclease activity => ECO:0000255|PROSITE-ProRule:PRU01366, ECO:0000269|PubMed:25528417

Chain	Residue	Details
A	TYR210

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01366, ECO:0000269|PubMed:25528417

Chain	Residue	Details
A	GLU119
A	HIS127
A	HIS129

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