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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

4POL

Crystal structures of thioredoxin with mesna at 2.8A resolution

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0004791molecular_functionthioredoxin-disulfide reductase (NADPH) activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006351biological_processDNA-templated transcription
A0009314biological_processresponse to radiation
A0015035molecular_functionprotein-disulfide reductase activity
A0019725biological_processcellular homeostasis
A0042803molecular_functionprotein homodimerization activity
A0043388biological_processpositive regulation of DNA binding
A0045454biological_processcell redox homeostasis
A0047134molecular_functionprotein-disulfide reductase [NAD(P)H] activity
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0055114biological_processobsolete oxidation-reduction process
A0061692biological_processcellular detoxification of hydrogen peroxide
A0070062cellular_componentextracellular exosome
A0071731biological_processresponse to nitric oxide
B0003723molecular_functionRNA binding
B0004791molecular_functionthioredoxin-disulfide reductase (NADPH) activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006351biological_processDNA-templated transcription
B0009314biological_processresponse to radiation
B0015035molecular_functionprotein-disulfide reductase activity
B0019725biological_processcellular homeostasis
B0042803molecular_functionprotein homodimerization activity
B0043388biological_processpositive regulation of DNA binding
B0045454biological_processcell redox homeostasis
B0047134molecular_functionprotein-disulfide reductase [NAD(P)H] activity
B0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0055114biological_processobsolete oxidation-reduction process
B0061692biological_processcellular detoxification of hydrogen peroxide
B0070062cellular_componentextracellular exosome
B0071731biological_processresponse to nitric oxide
C0003723molecular_functionRNA binding
C0004791molecular_functionthioredoxin-disulfide reductase (NADPH) activity
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006351biological_processDNA-templated transcription
C0009314biological_processresponse to radiation
C0015035molecular_functionprotein-disulfide reductase activity
C0019725biological_processcellular homeostasis
C0042803molecular_functionprotein homodimerization activity
C0043388biological_processpositive regulation of DNA binding
C0045454biological_processcell redox homeostasis
C0047134molecular_functionprotein-disulfide reductase [NAD(P)H] activity
C0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C0055114biological_processobsolete oxidation-reduction process
C0061692biological_processcellular detoxification of hydrogen peroxide
C0070062cellular_componentextracellular exosome
C0071731biological_processresponse to nitric oxide
D0003723molecular_functionRNA binding
D0004791molecular_functionthioredoxin-disulfide reductase (NADPH) activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006351biological_processDNA-templated transcription
D0009314biological_processresponse to radiation
D0015035molecular_functionprotein-disulfide reductase activity
D0019725biological_processcellular homeostasis
D0042803molecular_functionprotein homodimerization activity
D0043388biological_processpositive regulation of DNA binding
D0045454biological_processcell redox homeostasis
D0047134molecular_functionprotein-disulfide reductase [NAD(P)H] activity
D0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D0055114biological_processobsolete oxidation-reduction process
D0061692biological_processcellular detoxification of hydrogen peroxide
D0070062cellular_componentextracellular exosome
D0071731biological_processresponse to nitric oxide
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE COM A 200
ChainResidue
AGLU68
ACYS69
APHE80
CLYS8
site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE COM A 201
ChainResidue
AGLU6
AASP61
ACYS62
ALYS96
site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE COM B 200
ChainResidue
BCYS69
BGLN78
BPHE80
BLYS85
DLYS8
BGLU68
site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE COM B 201
ChainResidue
BGLU6
BASP61
BCYS62
BLYS96
Functional Information from PROSITE/UniProt
site_idPS00194
Number of Residues19
DetailsTHIOREDOXIN_1 Thioredoxin family active site. VVdFSatWCGPCKmIkpfF
ChainResidueDetails
AVAL24-PHE42
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues412
DetailsDomain: {"description":"Thioredoxin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00691","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues8
DetailsActive site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"9108029","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues4
DetailsSite: {"description":"Deprotonates C-terminal active site Cys","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues8
DetailsSite: {"description":"Contributes to redox potential value","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues8
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues4
DetailsModified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P10639","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues8
DetailsModified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"17260951","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues4
DetailsModified residue: {"description":"S-nitrosocysteine; alternate","evidences":[{"source":"PubMed","id":"16408020","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17606900","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues4
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P10639","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

246905

PDB entries from 2025-12-31

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