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4POL

Crystal structures of thioredoxin with mesna at 2.8A resolution

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0003723molecular_functionRNA binding
A0004791molecular_functionthioredoxin-disulfide reductase (NADPH) activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0009314biological_processresponse to radiation
A0015035molecular_functionprotein-disulfide reductase activity
A0032148biological_processactivation of protein kinase B activity
A0033138biological_processpositive regulation of peptidyl-serine phosphorylation
A0042803molecular_functionprotein homodimerization activity
A0043388biological_processpositive regulation of DNA binding
A0045454biological_processcell redox homeostasis
A0046826biological_processnegative regulation of protein export from nucleus
A0047134molecular_functionprotein-disulfide reductase (NAD(P)H) activity
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0055114biological_processobsolete oxidation-reduction process
A0061692biological_processcellular detoxification of hydrogen peroxide
A0070062cellular_componentextracellular exosome
A0071731biological_processresponse to nitric oxide
A2000170biological_processpositive regulation of peptidyl-cysteine S-nitrosylation
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0003723molecular_functionRNA binding
B0004791molecular_functionthioredoxin-disulfide reductase (NADPH) activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0009314biological_processresponse to radiation
B0015035molecular_functionprotein-disulfide reductase activity
B0032148biological_processactivation of protein kinase B activity
B0033138biological_processpositive regulation of peptidyl-serine phosphorylation
B0042803molecular_functionprotein homodimerization activity
B0043388biological_processpositive regulation of DNA binding
B0045454biological_processcell redox homeostasis
B0046826biological_processnegative regulation of protein export from nucleus
B0047134molecular_functionprotein-disulfide reductase (NAD(P)H) activity
B0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0055114biological_processobsolete oxidation-reduction process
B0061692biological_processcellular detoxification of hydrogen peroxide
B0070062cellular_componentextracellular exosome
B0071731biological_processresponse to nitric oxide
B2000170biological_processpositive regulation of peptidyl-cysteine S-nitrosylation
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0003723molecular_functionRNA binding
C0004791molecular_functionthioredoxin-disulfide reductase (NADPH) activity
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0009314biological_processresponse to radiation
C0015035molecular_functionprotein-disulfide reductase activity
C0032148biological_processactivation of protein kinase B activity
C0033138biological_processpositive regulation of peptidyl-serine phosphorylation
C0042803molecular_functionprotein homodimerization activity
C0043388biological_processpositive regulation of DNA binding
C0045454biological_processcell redox homeostasis
C0046826biological_processnegative regulation of protein export from nucleus
C0047134molecular_functionprotein-disulfide reductase (NAD(P)H) activity
C0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C0055114biological_processobsolete oxidation-reduction process
C0061692biological_processcellular detoxification of hydrogen peroxide
C0070062cellular_componentextracellular exosome
C0071731biological_processresponse to nitric oxide
C2000170biological_processpositive regulation of peptidyl-cysteine S-nitrosylation
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0003723molecular_functionRNA binding
D0004791molecular_functionthioredoxin-disulfide reductase (NADPH) activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0009314biological_processresponse to radiation
D0015035molecular_functionprotein-disulfide reductase activity
D0032148biological_processactivation of protein kinase B activity
D0033138biological_processpositive regulation of peptidyl-serine phosphorylation
D0042803molecular_functionprotein homodimerization activity
D0043388biological_processpositive regulation of DNA binding
D0045454biological_processcell redox homeostasis
D0046826biological_processnegative regulation of protein export from nucleus
D0047134molecular_functionprotein-disulfide reductase (NAD(P)H) activity
D0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D0055114biological_processobsolete oxidation-reduction process
D0061692biological_processcellular detoxification of hydrogen peroxide
D0070062cellular_componentextracellular exosome
D0071731biological_processresponse to nitric oxide
D2000170biological_processpositive regulation of peptidyl-cysteine S-nitrosylation
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE COM A 200
ChainResidue
AGLU68
ACYS69
APHE80
CLYS8

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE COM A 201
ChainResidue
AGLU6
AASP61
ACYS62
ALYS96

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE COM B 200
ChainResidue
BCYS69
BGLN78
BPHE80
BLYS85
DLYS8
BGLU68

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE COM B 201
ChainResidue
BGLU6
BASP61
BCYS62
BLYS96

Functional Information from PROSITE/UniProt
site_idPS00194
Number of Residues19
DetailsTHIOREDOXIN_1 Thioredoxin family active site. VVdFSatWCGPCKmIkpfF
ChainResidueDetails
AVAL24-PHE42

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsACT_SITE: Nucleophile => ECO:0000269|PubMed:9108029
ChainResidueDetails
ACYS32
ACYS35
BCYS32
BCYS35
CCYS32
CCYS35
DCYS32
DCYS35

site_idSWS_FT_FI2
Number of Residues4
DetailsSITE: Deprotonates C-terminal active site Cys => ECO:0000305
ChainResidueDetails
AASP26
BASP26
CASP26
DASP26

site_idSWS_FT_FI3
Number of Residues8
DetailsSITE: Contributes to redox potential value => ECO:0000305
ChainResidueDetails
AGLY33
APRO34
BGLY33
BPRO34
CGLY33
CPRO34
DGLY33
DPRO34

site_idSWS_FT_FI4
Number of Residues8
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS3
ALYS39
BLYS3
BLYS39
CLYS3
CLYS39
DLYS3
DLYS39

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P10639
ChainResidueDetails
ALYS8
BLYS8
CLYS8
DLYS8

site_idSWS_FT_FI6
Number of Residues8
DetailsMOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:17260951
ChainResidueDetails
ACYS62
ACYS69
BCYS62
BCYS69
CCYS62
CCYS69
DCYS62
DCYS69

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: S-nitrosocysteine; alternate => ECO:0000269|PubMed:16408020, ECO:0000269|PubMed:17606900
ChainResidueDetails
ACYS73
BCYS73
CCYS73
DCYS73

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P10639
ChainResidueDetails
ALYS94
BLYS94
CLYS94
DLYS94

219140

PDB entries from 2024-05-01

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