4PLY
Crystal structure of ancestral apicomplexan malate dehydrogenase with malate.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| A | 0006089 | biological_process | lactate metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| B | 0006089 | biological_process | lactate metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| C | 0006089 | biological_process | lactate metabolic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0019752 | biological_process | carboxylic acid metabolic process |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| D | 0006089 | biological_process | lactate metabolic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0019752 | biological_process | carboxylic acid metabolic process |
| E | 0000166 | molecular_function | nucleotide binding |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| E | 0006089 | biological_process | lactate metabolic process |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| E | 0019752 | biological_process | carboxylic acid metabolic process |
| F | 0000166 | molecular_function | nucleotide binding |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| F | 0006089 | biological_process | lactate metabolic process |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| F | 0019752 | biological_process | carboxylic acid metabolic process |
| G | 0000166 | molecular_function | nucleotide binding |
| G | 0003824 | molecular_function | catalytic activity |
| G | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| G | 0006089 | biological_process | lactate metabolic process |
| G | 0016491 | molecular_function | oxidoreductase activity |
| G | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| G | 0019752 | biological_process | carboxylic acid metabolic process |
| H | 0000166 | molecular_function | nucleotide binding |
| H | 0003824 | molecular_function | catalytic activity |
| H | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| H | 0006089 | biological_process | lactate metabolic process |
| H | 0016491 | molecular_function | oxidoreductase activity |
| H | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| H | 0019752 | biological_process | carboxylic acid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 29 |
| Details | binding site for residue NAI B 401 |
| Chain | Residue |
| B | GLY13 |
| B | THR79 |
| B | ALA80 |
| B | GLY81 |
| B | ILE82 |
| B | PRO83 |
| B | LEU98 |
| B | ILE105 |
| B | VAL125 |
| B | ASN127 |
| B | MET150 |
| B | ASN14 |
| B | LEU154 |
| B | HIS182 |
| B | ALA237 |
| B | PRO241 |
| B | PYR402 |
| B | HOH513 |
| B | HOH514 |
| B | HOH515 |
| B | HOH522 |
| B | HOH569 |
| B | ILE15 |
| B | PHE34 |
| B | ASP35 |
| B | ILE36 |
| B | VAL37 |
| B | MET40 |
| B | TYR67 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue PYR B 402 |
| Chain | Residue |
| B | TRP93 |
| B | ARG95 |
| B | ASN127 |
| B | ARG158 |
| B | HIS182 |
| B | GLY225 |
| B | NAI401 |
| B | HOH560 |
| site_id | AC3 |
| Number of Residues | 26 |
| Details | binding site for residue NAI A 401 |
| Chain | Residue |
| A | GLY13 |
| A | ASN14 |
| A | ILE15 |
| A | ASP35 |
| A | ILE36 |
| A | VAL37 |
| A | MET40 |
| A | TYR67 |
| A | THR79 |
| A | ALA80 |
| A | GLY81 |
| A | ILE82 |
| A | PRO83 |
| A | ILE105 |
| A | VAL125 |
| A | ASN127 |
| A | MET150 |
| A | LEU154 |
| A | HIS182 |
| A | ALA237 |
| A | PRO241 |
| A | PYR402 |
| A | HOH514 |
| A | HOH540 |
| A | HOH545 |
| A | HOH557 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue PYR A 402 |
| Chain | Residue |
| A | TRP93 |
| A | ARG95 |
| A | ASN127 |
| A | ARG158 |
| A | HIS182 |
| A | GLY225 |
| A | NAI401 |
| A | HOH529 |
| site_id | AC5 |
| Number of Residues | 19 |
| Details | binding site for residue NAI C 401 |
| Chain | Residue |
| C | GLY13 |
| C | ASN14 |
| C | ILE15 |
| C | ASP35 |
| C | ILE36 |
| C | VAL37 |
| C | MET40 |
| C | THR79 |
| C | ALA80 |
| C | ILE105 |
| C | VAL125 |
| C | THR126 |
| C | ASN127 |
| C | LEU129 |
| C | MET150 |
| C | LEU154 |
| C | HIS182 |
| C | HOH514 |
| C | HOH593 |
| site_id | AC6 |
| Number of Residues | 24 |
| Details | binding site for residue NAI D 401 |
| Chain | Residue |
| D | THR79 |
| D | ALA80 |
| D | GLY81 |
| D | ILE105 |
| D | VAL125 |
| D | ASN127 |
| D | LEU129 |
| D | MET150 |
| D | LEU154 |
| D | HIS182 |
| D | ALA237 |
| D | PRO241 |
| D | PYR402 |
| D | HOH513 |
| D | HOH516 |
| D | GLY13 |
| D | ASN14 |
| D | ILE15 |
| D | PHE34 |
| D | ASP35 |
| D | ILE36 |
| D | VAL37 |
| D | MET40 |
| D | TYR67 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue PYR D 402 |
| Chain | Residue |
| D | ASN127 |
| D | ARG158 |
| D | HIS182 |
| D | NAI401 |
| site_id | AC8 |
| Number of Residues | 30 |
| Details | binding site for residue NAI F 401 |
| Chain | Residue |
| F | GLY13 |
| F | ASN14 |
| F | ILE15 |
| F | PHE34 |
| F | ASP35 |
| F | ILE36 |
| F | VAL37 |
| F | MET40 |
| F | THR79 |
| F | ALA80 |
| F | GLY81 |
| F | ILE82 |
| F | PRO83 |
| F | LEU98 |
| F | ASN102 |
| F | ILE105 |
| F | VAL125 |
| F | THR126 |
| F | ASN127 |
| F | MET150 |
| F | LEU154 |
| F | HIS182 |
| F | ALA237 |
| F | PRO241 |
| F | PYR402 |
| F | HOH509 |
| F | HOH511 |
| F | HOH512 |
| F | HOH516 |
| F | HOH598 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | binding site for residue PYR F 402 |
| Chain | Residue |
| F | TRP93 |
| F | ARG95 |
| F | ASN127 |
| F | LEU154 |
| F | ARG158 |
| F | HIS182 |
| F | NAI401 |
| F | HOH548 |
| site_id | AD1 |
| Number of Residues | 28 |
| Details | binding site for residue NAI E 401 |
| Chain | Residue |
| E | GLY13 |
| E | ASN14 |
| E | ILE15 |
| E | PHE34 |
| E | ASP35 |
| E | ILE36 |
| E | VAL37 |
| E | MET40 |
| E | THR79 |
| E | ALA80 |
| E | GLY81 |
| E | ILE82 |
| E | PRO83 |
| E | LEU98 |
| E | ASN102 |
| E | ILE105 |
| E | VAL125 |
| E | ASN127 |
| E | MET150 |
| E | LEU154 |
| E | HIS182 |
| E | ALA237 |
| E | PRO241 |
| E | PYR402 |
| E | HOH512 |
| E | HOH538 |
| E | HOH541 |
| E | HOH542 |
| site_id | AD2 |
| Number of Residues | 8 |
| Details | binding site for residue PYR E 402 |
| Chain | Residue |
| E | TRP93 |
| E | ARG95 |
| E | ASN127 |
| E | LEU154 |
| E | ARG158 |
| E | HIS182 |
| E | NAI401 |
| E | HOH530 |
| site_id | AD3 |
| Number of Residues | 22 |
| Details | binding site for residue NAI G 401 |
| Chain | Residue |
| G | GLY13 |
| G | ASN14 |
| G | ILE15 |
| G | PHE34 |
| G | ASP35 |
| G | ILE36 |
| G | VAL37 |
| G | MET40 |
| G | TYR67 |
| G | THR79 |
| G | ALA80 |
| G | GLY81 |
| G | ILE105 |
| G | VAL125 |
| G | ASN127 |
| G | MET150 |
| G | LEU154 |
| G | HIS182 |
| G | ALA237 |
| G | PRO241 |
| G | HOH509 |
| G | HOH544 |
| site_id | AD4 |
| Number of Residues | 19 |
| Details | binding site for residue NAI H 401 |
| Chain | Residue |
| H | GLY13 |
| H | ASN14 |
| H | ILE15 |
| H | ASP35 |
| H | ILE36 |
| H | VAL37 |
| H | MET40 |
| H | THR79 |
| H | ALA80 |
| H | GLY81 |
| H | ILE105 |
| H | VAL125 |
| H | ASN127 |
| H | MET150 |
| H | LEU154 |
| H | HIS182 |
| H | ALA237 |
| H | PRO241 |
| H | PYR402 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue PYR H 402 |
| Chain | Residue |
| H | ASN127 |
| H | ARG158 |
| H | HIS182 |
| H | GLY225 |
| H | NAI401 |
| H | HOH516 |
