Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4PLY

Crystal structure of ancestral apicomplexan malate dehydrogenase with malate.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003824	molecular_function	catalytic activity
A	0004459	molecular_function	L-lactate dehydrogenase activity
A	0006089	biological_process	lactate metabolic process
A	0006090	biological_process	pyruvate metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0019752	biological_process	carboxylic acid metabolic process
B	0000166	molecular_function	nucleotide binding
B	0003824	molecular_function	catalytic activity
B	0004459	molecular_function	L-lactate dehydrogenase activity
B	0006089	biological_process	lactate metabolic process
B	0006090	biological_process	pyruvate metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0019752	biological_process	carboxylic acid metabolic process
C	0000166	molecular_function	nucleotide binding
C	0003824	molecular_function	catalytic activity
C	0004459	molecular_function	L-lactate dehydrogenase activity
C	0006089	biological_process	lactate metabolic process
C	0006090	biological_process	pyruvate metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0019752	biological_process	carboxylic acid metabolic process
D	0000166	molecular_function	nucleotide binding
D	0003824	molecular_function	catalytic activity
D	0004459	molecular_function	L-lactate dehydrogenase activity
D	0006089	biological_process	lactate metabolic process
D	0006090	biological_process	pyruvate metabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0019752	biological_process	carboxylic acid metabolic process
E	0000166	molecular_function	nucleotide binding
E	0003824	molecular_function	catalytic activity
E	0004459	molecular_function	L-lactate dehydrogenase activity
E	0006089	biological_process	lactate metabolic process
E	0006090	biological_process	pyruvate metabolic process
E	0016491	molecular_function	oxidoreductase activity
E	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
E	0019752	biological_process	carboxylic acid metabolic process
F	0000166	molecular_function	nucleotide binding
F	0003824	molecular_function	catalytic activity
F	0004459	molecular_function	L-lactate dehydrogenase activity
F	0006089	biological_process	lactate metabolic process
F	0006090	biological_process	pyruvate metabolic process
F	0016491	molecular_function	oxidoreductase activity
F	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
F	0019752	biological_process	carboxylic acid metabolic process
G	0000166	molecular_function	nucleotide binding
G	0003824	molecular_function	catalytic activity
G	0004459	molecular_function	L-lactate dehydrogenase activity
G	0006089	biological_process	lactate metabolic process
G	0006090	biological_process	pyruvate metabolic process
G	0016491	molecular_function	oxidoreductase activity
G	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
G	0019752	biological_process	carboxylic acid metabolic process
H	0000166	molecular_function	nucleotide binding
H	0003824	molecular_function	catalytic activity
H	0004459	molecular_function	L-lactate dehydrogenase activity
H	0006089	biological_process	lactate metabolic process
H	0006090	biological_process	pyruvate metabolic process
H	0016491	molecular_function	oxidoreductase activity
H	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
H	0019752	biological_process	carboxylic acid metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	29
Details	binding site for residue NAI B 401

Chain	Residue
B	GLY13
B	THR79
B	ALA80
B	GLY81
B	ILE82
B	PRO83
B	LEU98
B	ILE105
B	VAL125
B	ASN127
B	MET150
B	ASN14
B	LEU154
B	HIS182
B	ALA237
B	PRO241
B	PYR402
B	HOH513
B	HOH514
B	HOH515
B	HOH522
B	HOH569
B	ILE15
B	PHE34
B	ASP35
B	ILE36
B	VAL37
B	MET40
B	TYR67

site_id	AC2
Number of Residues	8
Details	binding site for residue PYR B 402

Chain	Residue
B	TRP93
B	ARG95
B	ASN127
B	ARG158
B	HIS182
B	GLY225
B	NAI401
B	HOH560

site_id	AC3
Number of Residues	26
Details	binding site for residue NAI A 401

Chain	Residue
A	GLY13
A	ASN14
A	ILE15
A	ASP35
A	ILE36
A	VAL37
A	MET40
A	TYR67
A	THR79
A	ALA80
A	GLY81
A	ILE82
A	PRO83
A	ILE105
A	VAL125
A	ASN127
A	MET150
A	LEU154
A	HIS182
A	ALA237
A	PRO241
A	PYR402
A	HOH514
A	HOH540
A	HOH545
A	HOH557

site_id	AC4
Number of Residues	8
Details	binding site for residue PYR A 402

Chain	Residue
A	TRP93
A	ARG95
A	ASN127
A	ARG158
A	HIS182
A	GLY225
A	NAI401
A	HOH529

site_id	AC5
Number of Residues	19
Details	binding site for residue NAI C 401

Chain	Residue
C	GLY13
C	ASN14
C	ILE15
C	ASP35
C	ILE36
C	VAL37
C	MET40
C	THR79
C	ALA80
C	ILE105
C	VAL125
C	THR126
C	ASN127
C	LEU129
C	MET150
C	LEU154
C	HIS182
C	HOH514
C	HOH593

site_id	AC6
Number of Residues	24
Details	binding site for residue NAI D 401

Chain	Residue
D	THR79
D	ALA80
D	GLY81
D	ILE105
D	VAL125
D	ASN127
D	LEU129
D	MET150
D	LEU154
D	HIS182
D	ALA237
D	PRO241
D	PYR402
D	HOH513
D	HOH516
D	GLY13
D	ASN14
D	ILE15
D	PHE34
D	ASP35
D	ILE36
D	VAL37
D	MET40
D	TYR67

site_id	AC7
Number of Residues	4
Details	binding site for residue PYR D 402

Chain	Residue
D	ASN127
D	ARG158
D	HIS182
D	NAI401

site_id	AC8
Number of Residues	30
Details	binding site for residue NAI F 401

Chain	Residue
F	GLY13
F	ASN14
F	ILE15
F	PHE34
F	ASP35
F	ILE36
F	VAL37
F	MET40
F	THR79
F	ALA80
F	GLY81
F	ILE82
F	PRO83
F	LEU98
F	ASN102
F	ILE105
F	VAL125
F	THR126
F	ASN127
F	MET150
F	LEU154
F	HIS182
F	ALA237
F	PRO241
F	PYR402
F	HOH509
F	HOH511
F	HOH512
F	HOH516
F	HOH598

site_id	AC9
Number of Residues	8
Details	binding site for residue PYR F 402

Chain	Residue
F	TRP93
F	ARG95
F	ASN127
F	LEU154
F	ARG158
F	HIS182
F	NAI401
F	HOH548

site_id	AD1
Number of Residues	28
Details	binding site for residue NAI E 401

Chain	Residue
E	GLY13
E	ASN14
E	ILE15
E	PHE34
E	ASP35
E	ILE36
E	VAL37
E	MET40
E	THR79
E	ALA80
E	GLY81
E	ILE82
E	PRO83
E	LEU98
E	ASN102
E	ILE105
E	VAL125
E	ASN127
E	MET150
E	LEU154
E	HIS182
E	ALA237
E	PRO241
E	PYR402
E	HOH512
E	HOH538
E	HOH541
E	HOH542

site_id	AD2
Number of Residues	8
Details	binding site for residue PYR E 402

Chain	Residue
E	TRP93
E	ARG95
E	ASN127
E	LEU154
E	ARG158
E	HIS182
E	NAI401
E	HOH530

site_id	AD3
Number of Residues	22
Details	binding site for residue NAI G 401

Chain	Residue
G	GLY13
G	ASN14
G	ILE15
G	PHE34
G	ASP35
G	ILE36
G	VAL37
G	MET40
G	TYR67
G	THR79
G	ALA80
G	GLY81
G	ILE105
G	VAL125
G	ASN127
G	MET150
G	LEU154
G	HIS182
G	ALA237
G	PRO241
G	HOH509
G	HOH544

site_id	AD4
Number of Residues	19
Details	binding site for residue NAI H 401

Chain	Residue
H	GLY13
H	ASN14
H	ILE15
H	ASP35
H	ILE36
H	VAL37
H	MET40
H	THR79
H	ALA80
H	GLY81
H	ILE105
H	VAL125
H	ASN127
H	MET150
H	LEU154
H	HIS182
H	ALA237
H	PRO241
H	PYR402

site_id	AD5
Number of Residues	6
Details	binding site for residue PYR H 402

Chain	Residue
H	ASN127
H	ARG158
H	HIS182
H	GLY225
H	NAI401
H	HOH516

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)