4PLW
Crystal structure of ancestral apicomplexan malate dehydrogenase with lactate.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| A | 0006089 | biological_process | lactate metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| B | 0006089 | biological_process | lactate metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| C | 0006089 | biological_process | lactate metabolic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0019752 | biological_process | carboxylic acid metabolic process |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| D | 0006089 | biological_process | lactate metabolic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0019752 | biological_process | carboxylic acid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 33 |
| Details | binding site for residue NAI A 401 |
| Chain | Residue |
| A | GLY13 |
| A | GLY81 |
| A | PRO83 |
| A | ILE100 |
| A | VAL120 |
| A | THR121 |
| A | ASN122 |
| A | MET145 |
| A | LEU149 |
| A | HIS177 |
| A | ALA232 |
| A | ASN14 |
| A | PRO236 |
| A | PO4402 |
| A | HOH515 |
| A | HOH516 |
| A | HOH541 |
| A | HOH560 |
| A | HOH563 |
| A | HOH581 |
| A | HOH588 |
| A | HOH596 |
| A | ILE15 |
| A | HOH631 |
| A | HOH638 |
| A | HOH750 |
| D | GLY87 |
| A | ASP35 |
| A | ILE36 |
| A | VAL37 |
| A | MET40 |
| A | THR79 |
| A | ALA80 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue PO4 A 402 |
| Chain | Residue |
| A | ARG84 |
| A | ARG90 |
| A | ASN122 |
| A | ARG153 |
| A | HIS177 |
| A | GLY220 |
| A | NAI401 |
| A | HOH543 |
| site_id | AC3 |
| Number of Residues | 33 |
| Details | binding site for residue NAI B 401 |
| Chain | Residue |
| B | GLY13 |
| B | ASN14 |
| B | ILE15 |
| B | ASP35 |
| B | ILE36 |
| B | VAL37 |
| B | MET40 |
| B | THR79 |
| B | ALA80 |
| B | GLY81 |
| B | ILE82 |
| B | PRO83 |
| B | ILE100 |
| B | VAL120 |
| B | THR121 |
| B | ASN122 |
| B | MET145 |
| B | LEU149 |
| B | HIS177 |
| B | ALA232 |
| B | PRO236 |
| B | PO4402 |
| B | HOH527 |
| B | HOH528 |
| B | HOH531 |
| B | HOH542 |
| B | HOH545 |
| B | HOH558 |
| B | HOH559 |
| B | HOH560 |
| B | HOH574 |
| B | HOH625 |
| B | HOH700 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 B 402 |
| Chain | Residue |
| B | ASN122 |
| B | ARG153 |
| B | HIS177 |
| B | GLY220 |
| B | NAI401 |
| B | HOH547 |
| B | HOH611 |
| site_id | AC5 |
| Number of Residues | 34 |
| Details | binding site for residue NAI C 401 |
| Chain | Residue |
| C | MET145 |
| C | LEU149 |
| C | HIS177 |
| C | ALA232 |
| C | PRO236 |
| C | PO4402 |
| C | HOH560 |
| C | HOH561 |
| C | HOH577 |
| C | HOH593 |
| C | HOH617 |
| C | HOH663 |
| C | HOH677 |
| C | HOH680 |
| C | HOH689 |
| C | HOH702 |
| C | GLY13 |
| C | ASN14 |
| C | ILE15 |
| C | PHE34 |
| C | ASP35 |
| C | ILE36 |
| C | VAL37 |
| C | MET40 |
| C | TYR67 |
| C | THR79 |
| C | ALA80 |
| C | GLY81 |
| C | ILE82 |
| C | PRO83 |
| C | ASN97 |
| C | ILE100 |
| C | VAL120 |
| C | ASN122 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue PO4 C 402 |
| Chain | Residue |
| C | ARG84 |
| C | ARG90 |
| C | ASN122 |
| C | ARG153 |
| C | HIS177 |
| C | GLY220 |
| C | NAI401 |
| C | HOH634 |
| site_id | AC7 |
| Number of Residues | 32 |
| Details | binding site for residue NAI D 401 |
| Chain | Residue |
| D | GLY13 |
| D | ASN14 |
| D | ILE15 |
| D | ASP35 |
| D | ILE36 |
| D | VAL37 |
| D | MET40 |
| D | THR79 |
| D | ALA80 |
| D | GLY81 |
| D | ILE100 |
| D | VAL120 |
| D | ASN122 |
| D | LEU124 |
| D | MET145 |
| D | LEU149 |
| D | HIS177 |
| D | ALA232 |
| D | PRO236 |
| D | PO4402 |
| D | HOH542 |
| D | HOH560 |
| D | HOH561 |
| D | HOH576 |
| D | HOH585 |
| D | HOH606 |
| D | HOH615 |
| D | HOH617 |
| D | HOH629 |
| D | HOH631 |
| D | HOH636 |
| D | HOH648 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 D 402 |
| Chain | Residue |
| D | ASN122 |
| D | ARG153 |
| D | HIS177 |
| D | GLY220 |
| D | NAI401 |
| D | HOH719 |
| D | HOH730 |
