4PLW
Crystal structure of ancestral apicomplexan malate dehydrogenase with lactate.
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0003824 | molecular_function | catalytic activity |
A | 0004459 | molecular_function | L-lactate dehydrogenase activity |
A | 0006089 | biological_process | lactate metabolic process |
A | 0006090 | biological_process | pyruvate metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
A | 0019752 | biological_process | carboxylic acid metabolic process |
B | 0000166 | molecular_function | nucleotide binding |
B | 0003824 | molecular_function | catalytic activity |
B | 0004459 | molecular_function | L-lactate dehydrogenase activity |
B | 0006089 | biological_process | lactate metabolic process |
B | 0006090 | biological_process | pyruvate metabolic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
B | 0019752 | biological_process | carboxylic acid metabolic process |
C | 0000166 | molecular_function | nucleotide binding |
C | 0003824 | molecular_function | catalytic activity |
C | 0004459 | molecular_function | L-lactate dehydrogenase activity |
C | 0006089 | biological_process | lactate metabolic process |
C | 0006090 | biological_process | pyruvate metabolic process |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
C | 0019752 | biological_process | carboxylic acid metabolic process |
D | 0000166 | molecular_function | nucleotide binding |
D | 0003824 | molecular_function | catalytic activity |
D | 0004459 | molecular_function | L-lactate dehydrogenase activity |
D | 0006089 | biological_process | lactate metabolic process |
D | 0006090 | biological_process | pyruvate metabolic process |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
D | 0019752 | biological_process | carboxylic acid metabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 33 |
Details | binding site for residue NAI A 401 |
Chain | Residue |
A | GLY13 |
A | GLY81 |
A | PRO83 |
A | ILE100 |
A | VAL120 |
A | THR121 |
A | ASN122 |
A | MET145 |
A | LEU149 |
A | HIS177 |
A | ALA232 |
A | ASN14 |
A | PRO236 |
A | PO4402 |
A | HOH515 |
A | HOH516 |
A | HOH541 |
A | HOH560 |
A | HOH563 |
A | HOH581 |
A | HOH588 |
A | HOH596 |
A | ILE15 |
A | HOH631 |
A | HOH638 |
A | HOH750 |
D | GLY87 |
A | ASP35 |
A | ILE36 |
A | VAL37 |
A | MET40 |
A | THR79 |
A | ALA80 |
site_id | AC2 |
Number of Residues | 8 |
Details | binding site for residue PO4 A 402 |
Chain | Residue |
A | ARG84 |
A | ARG90 |
A | ASN122 |
A | ARG153 |
A | HIS177 |
A | GLY220 |
A | NAI401 |
A | HOH543 |
site_id | AC3 |
Number of Residues | 33 |
Details | binding site for residue NAI B 401 |
Chain | Residue |
B | GLY13 |
B | ASN14 |
B | ILE15 |
B | ASP35 |
B | ILE36 |
B | VAL37 |
B | MET40 |
B | THR79 |
B | ALA80 |
B | GLY81 |
B | ILE82 |
B | PRO83 |
B | ILE100 |
B | VAL120 |
B | THR121 |
B | ASN122 |
B | MET145 |
B | LEU149 |
B | HIS177 |
B | ALA232 |
B | PRO236 |
B | PO4402 |
B | HOH527 |
B | HOH528 |
B | HOH531 |
B | HOH542 |
B | HOH545 |
B | HOH558 |
B | HOH559 |
B | HOH560 |
B | HOH574 |
B | HOH625 |
B | HOH700 |
site_id | AC4 |
Number of Residues | 7 |
Details | binding site for residue PO4 B 402 |
Chain | Residue |
B | ASN122 |
B | ARG153 |
B | HIS177 |
B | GLY220 |
B | NAI401 |
B | HOH547 |
B | HOH611 |
site_id | AC5 |
Number of Residues | 34 |
Details | binding site for residue NAI C 401 |
Chain | Residue |
C | MET145 |
C | LEU149 |
C | HIS177 |
C | ALA232 |
C | PRO236 |
C | PO4402 |
C | HOH560 |
C | HOH561 |
C | HOH577 |
C | HOH593 |
C | HOH617 |
C | HOH663 |
C | HOH677 |
C | HOH680 |
C | HOH689 |
C | HOH702 |
C | GLY13 |
C | ASN14 |
C | ILE15 |
C | PHE34 |
C | ASP35 |
C | ILE36 |
C | VAL37 |
C | MET40 |
C | TYR67 |
C | THR79 |
C | ALA80 |
C | GLY81 |
C | ILE82 |
C | PRO83 |
C | ASN97 |
C | ILE100 |
C | VAL120 |
C | ASN122 |
site_id | AC6 |
Number of Residues | 8 |
Details | binding site for residue PO4 C 402 |
Chain | Residue |
C | ARG84 |
C | ARG90 |
C | ASN122 |
C | ARG153 |
C | HIS177 |
C | GLY220 |
C | NAI401 |
C | HOH634 |
site_id | AC7 |
Number of Residues | 32 |
Details | binding site for residue NAI D 401 |
Chain | Residue |
D | GLY13 |
D | ASN14 |
D | ILE15 |
D | ASP35 |
D | ILE36 |
D | VAL37 |
D | MET40 |
D | THR79 |
D | ALA80 |
D | GLY81 |
D | ILE100 |
D | VAL120 |
D | ASN122 |
D | LEU124 |
D | MET145 |
D | LEU149 |
D | HIS177 |
D | ALA232 |
D | PRO236 |
D | PO4402 |
D | HOH542 |
D | HOH560 |
D | HOH561 |
D | HOH576 |
D | HOH585 |
D | HOH606 |
D | HOH615 |
D | HOH617 |
D | HOH629 |
D | HOH631 |
D | HOH636 |
D | HOH648 |
site_id | AC8 |
Number of Residues | 7 |
Details | binding site for residue PO4 D 402 |
Chain | Residue |
D | ASN122 |
D | ARG153 |
D | HIS177 |
D | GLY220 |
D | NAI401 |
D | HOH719 |
D | HOH730 |