4PLT
Crystal structure of ancestral apicomplexan malate dehydrogenase with oxamate.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| A | 0006089 | biological_process | lactate metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| B | 0006089 | biological_process | lactate metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| C | 0006089 | biological_process | lactate metabolic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0019752 | biological_process | carboxylic acid metabolic process |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| D | 0006089 | biological_process | lactate metabolic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0019752 | biological_process | carboxylic acid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 34 |
| Details | binding site for residue NAI B 401 |
| Chain | Residue |
| B | GLY13 |
| B | THR79 |
| B | ALA80 |
| B | GLY81 |
| B | ILE82 |
| B | PRO83 |
| B | ASN102 |
| B | ILE105 |
| B | VAL125 |
| B | ASN127 |
| B | LEU129 |
| B | ASN14 |
| B | MET150 |
| B | LEU154 |
| B | HIS182 |
| B | ALA237 |
| B | PRO241 |
| B | OXM402 |
| B | HOH519 |
| B | HOH522 |
| B | HOH525 |
| B | HOH549 |
| B | ILE15 |
| B | HOH564 |
| B | HOH612 |
| B | HOH619 |
| B | HOH632 |
| B | HOH733 |
| B | PHE34 |
| B | ASP35 |
| B | ILE36 |
| B | VAL37 |
| B | MET40 |
| B | TYR67 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue OXM B 402 |
| Chain | Residue |
| B | TRP93 |
| B | ARG95 |
| B | ASN127 |
| B | ARG158 |
| B | HIS182 |
| B | GLY225 |
| B | ALA237 |
| B | NAI401 |
| B | HOH550 |
| B | HOH612 |
| site_id | AC3 |
| Number of Residues | 33 |
| Details | binding site for residue NAI A 401 |
| Chain | Residue |
| A | GLY13 |
| A | ASN14 |
| A | ILE15 |
| A | PHE34 |
| A | ASP35 |
| A | ILE36 |
| A | VAL37 |
| A | MET40 |
| A | TYR67 |
| A | THR79 |
| A | ALA80 |
| A | GLY81 |
| A | ILE82 |
| A | PRO83 |
| A | ILE105 |
| A | VAL125 |
| A | THR126 |
| A | ASN127 |
| A | MET150 |
| A | LEU154 |
| A | HIS182 |
| A | ALA237 |
| A | OXM402 |
| A | HOH522 |
| A | HOH527 |
| A | HOH537 |
| A | HOH554 |
| A | HOH561 |
| A | HOH599 |
| A | HOH625 |
| A | HOH642 |
| A | HOH661 |
| A | HOH725 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue OXM A 402 |
| Chain | Residue |
| A | TRP93 |
| A | ARG95 |
| A | ASN127 |
| A | ARG158 |
| A | HIS182 |
| A | ALA237 |
| A | NAI401 |
| A | HOH537 |
| A | HOH544 |
| site_id | AC5 |
| Number of Residues | 35 |
| Details | binding site for residue NAI C 401 |
| Chain | Residue |
| C | PRO83 |
| C | ASN102 |
| C | ILE105 |
| C | VAL125 |
| C | THR126 |
| C | ASN127 |
| C | LEU129 |
| C | MET150 |
| C | LEU154 |
| C | HIS182 |
| C | ALA237 |
| C | PRO241 |
| C | OXM402 |
| C | HOH527 |
| C | HOH545 |
| C | HOH563 |
| C | HOH572 |
| C | HOH573 |
| C | HOH583 |
| C | HOH589 |
| C | HOH604 |
| C | HOH673 |
| C | GLY13 |
| C | ASN14 |
| C | ILE15 |
| C | PHE34 |
| C | ASP35 |
| C | ILE36 |
| C | VAL37 |
| C | MET40 |
| C | TYR67 |
| C | THR79 |
| C | ALA80 |
| C | GLY81 |
| C | ILE82 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | binding site for residue OXM C 402 |
| Chain | Residue |
| C | TRP93 |
| C | ARG95 |
| C | ASN127 |
| C | ARG158 |
| C | HIS182 |
| C | GLY225 |
| C | NAI401 |
| C | HOH544 |
| C | HOH572 |
| site_id | AC7 |
| Number of Residues | 34 |
| Details | binding site for residue NAI D 401 |
| Chain | Residue |
| D | GLY13 |
| D | ASN14 |
| D | ILE15 |
| D | PHE34 |
| D | ASP35 |
| D | ILE36 |
| D | VAL37 |
| D | MET40 |
| D | THR79 |
| D | ALA80 |
| D | GLY81 |
| D | ILE82 |
| D | PRO83 |
| D | LEU98 |
| D | ASN102 |
| D | ILE105 |
| D | VAL125 |
| D | ASN127 |
| D | MET150 |
| D | LEU154 |
| D | HIS182 |
| D | ALA237 |
| D | PRO241 |
| D | OXM402 |
| D | HOH520 |
| D | HOH548 |
| D | HOH549 |
| D | HOH556 |
| D | HOH566 |
| D | HOH574 |
| D | HOH609 |
| D | HOH619 |
| D | HOH629 |
| D | HOH652 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | binding site for residue OXM D 402 |
| Chain | Residue |
| D | TRP93 |
| D | ARG95 |
| D | ASN127 |
| D | ARG158 |
| D | HIS182 |
| D | NAI401 |
| D | HOH524 |
| D | HOH566 |
