4PKD

U1-70k in complex with U1 snRNA stem-loops 1 and U1-A RRM in complex with stem-loop 2

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0003676	molecular_function	nucleic acid binding
B	0003723	molecular_function	RNA binding
B	0030619	molecular_function	U1 snRNA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue MG V 201

Chain	Residue
V	A91
V	U92
V	G103
V	HOH314
V	HOH318
V	HOH319
V	HOH329

---

site_id	AC2
Number of Residues	3
Details	binding site for residue MG V 202

Chain	Residue
V	HOH319
V	U92
V	HOH317

---

site_id	AC3
Number of Residues	3
Details	binding site for residue MG B 301

Chain	Residue
B	LEU151
B	TRP154
B	HOH420

---

site_id	AC4
Number of Residues	3
Details	binding site for residue IMD B 302

Chain	Residue
B	ASP92
V	C71
V	U72

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	78
Details	Domain: {"description":"RRM","evidences":[{"source":"PROSITE-ProRule","id":"PRU00176","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	110
Details	Region: {"description":"Required for interaction with U1 RNA","evidences":[{"source":"PubMed","id":"2467746","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	Compositional bias: {"description":"Gly residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	79
Details	Domain: {"description":"RRM 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00176","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P09012","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---