4PIP
Engineered EgtD variant EgtD-M252V,E282A in complex with tryptophan and SAH
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0008168 | molecular_function | methyltransferase activity |
A | 0008276 | molecular_function | protein methyltransferase activity |
A | 0016740 | molecular_function | transferase activity |
A | 0030745 | molecular_function | dimethylhistidine N-methyltransferase activity |
A | 0032259 | biological_process | methylation |
A | 0052699 | biological_process | ergothioneine biosynthetic process |
A | 0052704 | biological_process | ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide |
A | 0052707 | biological_process | N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthesis from histidine |
B | 0008168 | molecular_function | methyltransferase activity |
B | 0008276 | molecular_function | protein methyltransferase activity |
B | 0016740 | molecular_function | transferase activity |
B | 0030745 | molecular_function | dimethylhistidine N-methyltransferase activity |
B | 0032259 | biological_process | methylation |
B | 0052699 | biological_process | ergothioneine biosynthetic process |
B | 0052704 | biological_process | ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide |
B | 0052707 | biological_process | N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthesis from histidine |
C | 0008168 | molecular_function | methyltransferase activity |
C | 0008276 | molecular_function | protein methyltransferase activity |
C | 0016740 | molecular_function | transferase activity |
C | 0030745 | molecular_function | dimethylhistidine N-methyltransferase activity |
C | 0032259 | biological_process | methylation |
C | 0052699 | biological_process | ergothioneine biosynthetic process |
C | 0052704 | biological_process | ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide |
C | 0052707 | biological_process | N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthesis from histidine |
D | 0008168 | molecular_function | methyltransferase activity |
D | 0008276 | molecular_function | protein methyltransferase activity |
D | 0016740 | molecular_function | transferase activity |
D | 0030745 | molecular_function | dimethylhistidine N-methyltransferase activity |
D | 0032259 | biological_process | methylation |
D | 0052699 | biological_process | ergothioneine biosynthetic process |
D | 0052704 | biological_process | ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide |
D | 0052707 | biological_process | N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthesis from histidine |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 10 |
Details | binding site for residue TRP A 401 |
Chain | Residue |
A | TYR39 |
A | HOH743 |
A | PHE47 |
A | TYR56 |
A | GLY161 |
A | ASN166 |
A | TYR206 |
A | ALA282 |
A | SER284 |
A | HOH633 |
site_id | AC2 |
Number of Residues | 21 |
Details | binding site for residue SAH A 402 |
Chain | Residue |
A | LYS36 |
A | TYR39 |
A | GLU84 |
A | GLY86 |
A | SER87 |
A | THR89 |
A | LYS92 |
A | ASP113 |
A | VAL114 |
A | GLY140 |
A | ASP141 |
A | PHE142 |
A | LEU160 |
A | GLY161 |
A | HOH635 |
A | HOH640 |
A | HOH642 |
A | HOH649 |
A | HOH690 |
A | HOH693 |
A | HOH699 |
site_id | AC3 |
Number of Residues | 10 |
Details | binding site for residue TRP B 401 |
Chain | Residue |
B | TYR39 |
B | TYR56 |
B | GLY161 |
B | ASN166 |
B | TYR206 |
B | ALA282 |
B | SER284 |
B | HOH741 |
B | HOH745 |
B | HOH756 |
site_id | AC4 |
Number of Residues | 21 |
Details | binding site for residue SAH B 402 |
Chain | Residue |
B | LYS36 |
B | TYR39 |
B | PHE47 |
B | GLY86 |
B | SER87 |
B | LYS92 |
B | ASP113 |
B | VAL114 |
B | GLY140 |
B | ASP141 |
B | PHE142 |
B | LEU160 |
B | GLY161 |
B | HOH623 |
B | HOH629 |
B | HOH657 |
B | HOH665 |
B | HOH683 |
B | HOH703 |
B | HOH720 |
B | HOH757 |
site_id | AC5 |
Number of Residues | 6 |
Details | binding site for residue MG B 403 |
Chain | Residue |
B | HOH522 |
B | HOH539 |
B | HOH553 |
C | HOH529 |
C | HOH546 |
C | HOH577 |
site_id | AC6 |
Number of Residues | 4 |
Details | binding site for residue CL C 401 |
Chain | Residue |
C | GLY-1 |
C | HIS0 |
C | HOH592 |
D | HIS305 |
site_id | AC7 |
Number of Residues | 11 |
Details | binding site for residue TRP C 402 |
Chain | Residue |
C | PHE47 |
C | TYR56 |
C | GLY161 |
C | THR163 |
C | ASN166 |
C | TYR206 |
C | PHE216 |
C | ALA282 |
C | SER284 |
C | HOH750 |
C | HOH805 |
site_id | AC8 |
Number of Residues | 20 |
Details | binding site for residue SAH C 403 |
Chain | Residue |
C | HOH658 |
C | HOH662 |
C | HOH710 |
C | HOH822 |
C | LYS36 |
C | TYR39 |
C | PHE47 |
C | GLY86 |
C | SER87 |
C | GLY88 |
C | LYS92 |
C | ASP113 |
C | VAL114 |
C | GLY140 |
C | ASP141 |
C | PHE142 |
C | GLY161 |
C | THR163 |
C | HOH634 |
C | HOH647 |
site_id | AC9 |
Number of Residues | 6 |
Details | binding site for residue MG C 404 |
Chain | Residue |
B | HOH524 |
B | HOH542 |
B | HOH583 |
C | HOH531 |
C | HOH572 |
D | HOH520 |
site_id | AD1 |
Number of Residues | 11 |
Details | binding site for residue TRP D 401 |
Chain | Residue |
D | PHE38 |
D | PHE47 |
D | TYR56 |
D | GLY161 |
D | THR163 |
D | ASN166 |
D | TYR206 |
D | THR213 |
D | ALA282 |
D | SER284 |
D | HOH633 |
site_id | AD2 |
Number of Residues | 19 |
Details | binding site for residue SAH D 402 |
Chain | Residue |
D | TYR39 |
D | PHE47 |
D | GLY86 |
D | SER87 |
D | GLY88 |
D | LYS92 |
D | ASP113 |
D | VAL114 |
D | GLY140 |
D | ASP141 |
D | PHE142 |
D | GLY161 |
D | THR163 |
D | HOH649 |
D | HOH657 |
D | HOH669 |
D | HOH673 |
D | HOH710 |
D | HOH797 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 16 |
Details | BINDING: BINDING => ECO:0000269|PubMed:25251321, ECO:0000305|PubMed:25404173, ECO:0007744|PDB:4UY6, ECO:0007744|PDB:4UY7 |
Chain | Residue | Details |
A | TYR56 | |
C | ASN166 | |
C | TYR206 | |
C | ALA282 | |
D | TYR56 | |
D | ASN166 | |
D | TYR206 | |
D | ALA282 | |
A | ASN166 | |
A | TYR206 | |
A | ALA282 | |
B | TYR56 | |
B | ASN166 | |
B | TYR206 | |
B | ALA282 | |
C | TYR56 |
site_id | SWS_FT_FI2 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000305|PubMed:25251321, ECO:0000305|PubMed:25404173 |
Chain | Residue | Details |
A | GLY86 | |
D | GLY86 | |
D | LYS92 | |
D | ASP113 | |
A | LYS92 | |
A | ASP113 | |
B | GLY86 | |
B | LYS92 | |
B | ASP113 | |
C | GLY86 | |
C | LYS92 | |
C | ASP113 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000305|PubMed:25251321, ECO:0000305|PubMed:25404173, ECO:0007744|PDB:4PIO, ECO:0007744|PDB:4PIP, ECO:0007744|PDB:4UY6 |
Chain | Residue | Details |
A | ASP141 | |
B | ASP141 | |
C | ASP141 | |
D | ASP141 |