4PC7

Elongation factor Tu:Ts complex in a near GTP conformation.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003746	molecular_function	translation elongation factor activity
A	0003924	molecular_function	GTPase activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0006412	biological_process	translation
A	0006414	biological_process	translational elongation
A	0032045	cellular_component	guanyl-nucleotide exchange factor complex
A	0046677	biological_process	response to antibiotic
A	0097216	molecular_function	guanosine tetraphosphate binding
C	0003746	molecular_function	translation elongation factor activity
C	0005085	molecular_function	guanyl-nucleotide exchange factor activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006412	biological_process	translation
C	0006414	biological_process	translational elongation
C	0008270	molecular_function	zinc ion binding
C	0016020	cellular_component	membrane
C	0032045	cellular_component	guanyl-nucleotide exchange factor complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue GNP A 401

Chain	Residue
A	VAL20
A	ASN135
A	LYS136
A	ASP138
A	MET139
A	SER173
A	ALA174
A	LEU175
A	MG403
A	HOH501
A	ASP21
A	HIS22
A	GLY23
A	LYS24
A	THR25
A	THR26
A	PRO82
A	GLY83

---

site_id	AC2
Number of Residues	21
Details	binding site for residue PUL A 402

Chain	Residue
A	ILE92
A	THR93
A	GLN97
A	GLN124
A	VAL125
A	PRO213
A	GLU215
A	THR228
A	GLY229
A	ARG230
A	GLU259
A	PHE261
A	ARG262
A	ASN273
A	VAL274
A	TYR331
A	ARG333
A	THR334
A	ARG373
A	ALA375
A	ARG377

---

site_id	AC3
Number of Residues	5
Details	binding site for residue MG A 403

Chain	Residue
A	THR25
A	ASP80
A	CYS81
A	GNP401
A	HOH501

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Functional Information from PROSITE/UniProt

site_id	PS01126
Number of Residues	16
Details	EF_TS_1 Elongation factor Ts signature 1. LRerTGaGMmDcKKAL

Chain	Residue	Details
C	LEU11-LEU26

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site_id	PS01127
Number of Residues	11
Details	EF_TS_2 Elongation factor Ts signature 2. EVNCQTDFVAK

Chain	Residue	Details
C	GLU74-LYS84

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site_id	PS00301
Number of Residues	16
Details	G_TR_1 Translational (tr)-type guanine nucleotide-binding (G) domain signature. DNapeEKaRGITIntS

Chain	Residue	Details
A	ASP50-SER65

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING:

Chain	Residue	Details
A	GLY18
A	ASP80
A	ASN135

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N-acetylserine => ECO:0000269|PubMed:6997043, ECO:0000269|PubMed:7021545

Chain	Residue	Details
A	SER1

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:2022614, ECO:0000269|PubMed:389663, ECO:0000269|PubMed:6997043, ECO:0000269|PubMed:7021545

Chain	Residue	Details
A	LYS56

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:18723842

Chain	Residue	Details
A	LYS313

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:19150849, ECO:0000269|PubMed:24141193, ECO:0000269|PubMed:8416965

Chain	Residue	Details
A	THR382

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	4
Details	M-CSA 535

Chain	Residue	Details
A	ASP21	electrostatic stabiliser
A	LYS24	electrostatic stabiliser
A	THR25	metal ligand
A	HIS84	electrostatic stabiliser

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