4PC3
Elongation factor Tu:Ts complex with partially bound GDP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003746 | molecular_function | translation elongation factor activity |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006412 | biological_process | translation |
| A | 0006414 | biological_process | translational elongation |
| A | 0032045 | cellular_component | guanyl-nucleotide exchange factor complex |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0097216 | molecular_function | guanosine tetraphosphate binding |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003746 | molecular_function | translation elongation factor activity |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006412 | biological_process | translation |
| B | 0006414 | biological_process | translational elongation |
| B | 0032045 | cellular_component | guanyl-nucleotide exchange factor complex |
| B | 0046677 | biological_process | response to antibiotic |
| B | 0097216 | molecular_function | guanosine tetraphosphate binding |
| C | 0003746 | molecular_function | translation elongation factor activity |
| C | 0005085 | molecular_function | guanyl-nucleotide exchange factor activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006412 | biological_process | translation |
| C | 0006414 | biological_process | translational elongation |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0016020 | cellular_component | membrane |
| C | 0032045 | cellular_component | guanyl-nucleotide exchange factor complex |
| D | 0003746 | molecular_function | translation elongation factor activity |
| D | 0005085 | molecular_function | guanyl-nucleotide exchange factor activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006412 | biological_process | translation |
| D | 0006414 | biological_process | translational elongation |
| D | 0008270 | molecular_function | zinc ion binding |
| D | 0016020 | cellular_component | membrane |
| D | 0032045 | cellular_component | guanyl-nucleotide exchange factor complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue GDP A 401 |
| Chain | Residue |
| A | HIS19 |
| A | LYS136 |
| A | ASP138 |
| A | MET139 |
| A | SER173 |
| A | ALA174 |
| A | LEU175 |
| A | VAL20 |
| A | ASP21 |
| A | HIS22 |
| A | GLY23 |
| A | LYS24 |
| A | THR25 |
| A | THR26 |
| A | ASN135 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue GOL C 301 |
| Chain | Residue |
| C | GLU193 |
| C | GLN197 |
| C | ARG218 |
| C | LYS221 |
| C | GLU225 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue GOL C 302 |
| Chain | Residue |
| C | GLN203 |
| C | SER204 |
| C | HOH416 |
| C | HOH487 |
| C | HOH524 |
| D | GLU178 |
| D | PHE179 |
| D | HOH502 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | binding site for residue GDP B 401 |
| Chain | Residue |
| B | HIS19 |
| B | ASP21 |
| B | GLY23 |
| B | LYS24 |
| B | THR25 |
| B | THR26 |
| B | ASN135 |
| B | LYS136 |
| B | ASP138 |
| B | MET139 |
| B | SER173 |
| B | ALA174 |
| B | LEU175 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 402 |
| Chain | Residue |
| B | ARG58 |
| B | ARG377 |
| B | GLY380 |
| B | ARG381 |
| B | THR382 |
| B | HOH578 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue GOL D 301 |
| Chain | Residue |
| C | GLU178 |
| C | ILE180 |
| D | GLN203 |
| D | SER204 |
| D | HOH422 |
| D | HOH454 |
| D | HOH496 |
| D | HOH526 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue GOL D 302 |
| Chain | Residue |
| D | GLU193 |
| D | GLN197 |
| D | ARG218 |
| D | LYS221 |
| D | PHE222 |
| D | GLU225 |
Functional Information from PROSITE/UniProt
| site_id | PS00301 |
| Number of Residues | 16 |
| Details | G_TR_1 Translational (tr)-type guanine nucleotide-binding (G) domain signature. DNapeEKaRGITIntS |
| Chain | Residue | Details |
| A | ASP50-SER65 |
| site_id | PS01126 |
| Number of Residues | 16 |
| Details | EF_TS_1 Elongation factor Ts signature 1. LRerTGaGMmDcKKAL |
| Chain | Residue | Details |
| C | LEU11-LEU26 |
| site_id | PS01127 |
| Number of Residues | 11 |
| Details | EF_TS_2 Elongation factor Ts signature 2. EVNCQTDFVAK |
| Chain | Residue | Details |
| C | GLU74-LYS84 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | GLY18 | |
| A | ASP80 | |
| A | ASN135 | |
| B | GLY18 | |
| B | ASP80 | |
| B | ASN135 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylserine => ECO:0000269|PubMed:6997043, ECO:0000269|PubMed:7021545 |
| Chain | Residue | Details |
| A | SER1 | |
| B | SER1 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:2022614, ECO:0000269|PubMed:389663, ECO:0000269|PubMed:6997043, ECO:0000269|PubMed:7021545 |
| Chain | Residue | Details |
| A | LYS56 | |
| B | LYS56 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:18723842 |
| Chain | Residue | Details |
| A | LYS313 | |
| B | LYS313 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:19150849, ECO:0000269|PubMed:24141193, ECO:0000269|PubMed:8416965 |
| Chain | Residue | Details |
| A | THR382 | |
| B | THR382 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 535 |
| Chain | Residue | Details |
| A | ASP21 | electrostatic stabiliser |
| A | LYS24 | electrostatic stabiliser |
| A | THR25 | metal ligand |
| A | HIS84 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 535 |
| Chain | Residue | Details |
| B | ASP21 | electrostatic stabiliser |
| B | LYS24 | electrostatic stabiliser |
| B | THR25 | metal ligand |
| B | HIS84 | electrostatic stabiliser |
