4PAB
Crystal structure of the precursor form of rat DMGDH complexed with tetrahydrofolate
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005542 | molecular_function | folic acid binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005739 | cellular_component | mitochondrion |
A | 0005759 | cellular_component | mitochondrial matrix |
A | 0006579 | biological_process | amino-acid betaine catabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0019695 | biological_process | choline metabolic process |
A | 0035999 | biological_process | tetrahydrofolate interconversion |
A | 0042426 | biological_process | choline catabolic process |
A | 0047865 | molecular_function | dimethylglycine dehydrogenase activity |
A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
B | 0005542 | molecular_function | folic acid binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0005739 | cellular_component | mitochondrion |
B | 0005759 | cellular_component | mitochondrial matrix |
B | 0006579 | biological_process | amino-acid betaine catabolic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0019695 | biological_process | choline metabolic process |
B | 0035999 | biological_process | tetrahydrofolate interconversion |
B | 0042426 | biological_process | choline catabolic process |
B | 0047865 | molecular_function | dimethylglycine dehydrogenase activity |
B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 17 |
Details | binding site for residue THG A 902 |
Chain | Residue |
A | ILE560 |
A | PHE717 |
A | TYR737 |
A | SCN906 |
A | HOH1130 |
A | HOH1181 |
A | HOH1182 |
A | HOH1282 |
A | HOH1304 |
A | GLU573 |
A | THR575 |
A | ILE587 |
A | PHE649 |
A | LEU650 |
A | TYR669 |
A | GLU676 |
A | TYR678 |
site_id | AC2 |
Number of Residues | 3 |
Details | binding site for residue SCN A 903 |
Chain | Residue |
A | TYR103 |
A | THR152 |
A | HOH1290 |
site_id | AC3 |
Number of Residues | 2 |
Details | binding site for residue SCN A 904 |
Chain | Residue |
A | TYR571 |
A | ARG598 |
site_id | AC4 |
Number of Residues | 2 |
Details | binding site for residue SCN A 905 |
Chain | Residue |
A | ASP618 |
A | ARG681 |
site_id | AC5 |
Number of Residues | 9 |
Details | binding site for residue SCN A 906 |
Chain | Residue |
A | PHE649 |
A | ILE667 |
A | SER668 |
A | GLY671 |
A | THR843 |
A | PRO845 |
A | THG902 |
A | HOH1130 |
A | HOH1258 |
site_id | AC6 |
Number of Residues | 16 |
Details | binding site for residue THG B 902 |
Chain | Residue |
B | ILE560 |
B | GLU573 |
B | THR575 |
B | ILE587 |
B | PHE649 |
B | LEU650 |
B | TYR669 |
B | GLU676 |
B | TYR678 |
B | PHE717 |
B | TYR737 |
B | HOH1112 |
B | HOH1303 |
B | HOH1327 |
B | HOH1329 |
B | HOH1331 |
site_id | AC7 |
Number of Residues | 2 |
Details | binding site for residue SCN B 903 |
Chain | Residue |
B | TYR103 |
B | THR152 |
site_id | AC8 |
Number of Residues | 2 |
Details | binding site for residue SCN B 904 |
Chain | Residue |
B | TYR571 |
B | ARG598 |
site_id | AC9 |
Number of Residues | 5 |
Details | binding site for residue SCN B 905 |
Chain | Residue |
B | TRP428 |
B | ARG463 |
B | ASP618 |
B | HOH1113 |
B | HOH1332 |
site_id | AD1 |
Number of Residues | 2 |
Details | binding site for residue SCN B 906 |
Chain | Residue |
A | GLN851 |
B | GLN851 |
site_id | AD2 |
Number of Residues | 40 |
Details | binding site for residue FAD A 901 |
Chain | Residue |
A | HOH1308 |
A | ILE48 |
A | GLY49 |
A | GLY50 |
A | GLY51 |
A | CYS52 |
A | VAL53 |
A | LEU72 |
A | GLU73 |
A | LYS74 |
A | ALA79 |
A | GLY80 |
A | SER81 |
A | THR82 |
A | HIS84 |
A | ALA85 |
A | ALA86 |
A | GLY87 |
A | LEU88 |
A | PRO211 |
A | VAL212 |
A | ALA240 |
A | ALA241 |
A | GLY242 |
A | TRP244 |
A | HIS263 |
A | TYR265 |
A | GLY363 |
A | PRO364 |
A | ILE365 |
A | PHE390 |
A | TYR392 |
A | GLY393 |
A | ILE394 |
A | ILE395 |
A | HOH1028 |
A | HOH1046 |
A | HOH1120 |
A | HOH1123 |
A | HOH1225 |
site_id | AD3 |
Number of Residues | 38 |
Details | binding site for residue FAD B 901 |
Chain | Residue |
B | ILE48 |
B | GLY49 |
B | GLY51 |
B | CYS52 |
B | VAL53 |
B | LEU72 |
B | GLU73 |
B | LYS74 |
B | GLY80 |
B | SER81 |
B | THR82 |
B | HIS84 |
B | ALA85 |
B | ALA86 |
B | GLY87 |
B | LEU88 |
B | PRO211 |
B | VAL212 |
B | ALA240 |
B | ALA241 |
B | GLY242 |
B | TRP244 |
B | HIS263 |
B | TYR265 |
B | GLY363 |
B | PRO364 |
B | ILE365 |
B | PHE390 |
B | TYR392 |
B | GLY393 |
B | ILE394 |
B | ILE395 |
B | HOH1053 |
B | HOH1085 |
B | HOH1108 |
B | HOH1174 |
B | HOH1240 |
B | HOH1290 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 10 |
Details | BINDING: BINDING => ECO:0000269|PubMed:24858690, ECO:0007744|PDB:4P9S, ECO:0007744|PDB:4PAA, ECO:0007744|PDB:4PAB |
Chain | Residue | Details |
A | CYS52 | |
B | PHE390 | |
A | GLU73 | |
A | GLY80 | |
A | VAL212 | |
A | PHE390 | |
B | CYS52 | |
B | GLU73 | |
B | GLY80 | |
B | VAL212 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:24858690, ECO:0007744|PDB:4P9S, ECO:0007744|PDB:4PAB |
Chain | Residue | Details |
A | TRP244 | |
B | TRP244 |
site_id | SWS_FT_FI3 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:24858690, ECO:0007744|PDB:4PAA, ECO:0007744|PDB:4PAB |
Chain | Residue | Details |
A | GLU573 | |
A | GLU676 | |
A | TYR737 | |
B | GLU573 | |
B | GLU676 | |
B | TYR737 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:24858690, ECO:0007744|PDB:4PAA |
Chain | Residue | Details |
A | TYR669 | |
B | TYR669 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | MOD_RES: Tele-8alpha-FAD histidine => ECO:0000269|PubMed:24858690, ECO:0000269|PubMed:4055729, ECO:0007744|PDB:4P9S, ECO:0007744|PDB:4PAA, ECO:0007744|PDB:4PAB |
Chain | Residue | Details |
A | HIS84 | |
B | HIS84 |
site_id | SWS_FT_FI6 |
Number of Residues | 12 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9DBT9 |
Chain | Residue | Details |
A | LYS107 | |
B | LYS328 | |
B | LYS353 | |
B | LYS757 | |
A | LYS161 | |
A | LYS216 | |
A | LYS328 | |
A | LYS353 | |
A | LYS757 | |
B | LYS107 | |
B | LYS161 | |
B | LYS216 |
site_id | SWS_FT_FI7 |
Number of Residues | 12 |
Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9DBT9 |
Chain | Residue | Details |
A | LYS141 | |
B | LYS516 | |
B | LYS648 | |
B | LYS786 | |
A | LYS427 | |
A | LYS469 | |
A | LYS516 | |
A | LYS648 | |
A | LYS786 | |
B | LYS141 | |
B | LYS427 | |
B | LYS469 |
site_id | SWS_FT_FI8 |
Number of Residues | 6 |
Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q9DBT9 |
Chain | Residue | Details |
A | LYS310 | |
A | LYS312 | |
A | LYS788 | |
B | LYS310 | |
B | LYS312 | |
B | LYS788 |