4PAA
Crystal structure of the mature form of rat DMGDH complexed with tetrahydrofolate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005542 | molecular_function | folic acid binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0006579 | biological_process | amino-acid betaine catabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019695 | biological_process | choline metabolic process |
| A | 0035999 | biological_process | tetrahydrofolate interconversion |
| A | 0042426 | biological_process | choline catabolic process |
| A | 0047865 | molecular_function | dimethylglycine dehydrogenase activity |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0005542 | molecular_function | folic acid binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0006579 | biological_process | amino-acid betaine catabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0019695 | biological_process | choline metabolic process |
| B | 0035999 | biological_process | tetrahydrofolate interconversion |
| B | 0042426 | biological_process | choline catabolic process |
| B | 0047865 | molecular_function | dimethylglycine dehydrogenase activity |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 36 |
| Details | binding site for residue FAD A 901 |
| Chain | Residue |
| A | ILE48 |
| A | GLY80 |
| A | SER81 |
| A | THR82 |
| A | HIS84 |
| A | ALA85 |
| A | ALA86 |
| A | GLY87 |
| A | LEU88 |
| A | VAL212 |
| A | ALA241 |
| A | GLY49 |
| A | GLY242 |
| A | TRP244 |
| A | HIS263 |
| A | TYR265 |
| A | GLY363 |
| A | PRO364 |
| A | ILE365 |
| A | PHE390 |
| A | TYR392 |
| A | GLY393 |
| A | GLY51 |
| A | ILE394 |
| A | ILE395 |
| A | HOH1018 |
| A | HOH1021 |
| A | HOH1048 |
| A | HOH1072 |
| A | HOH1102 |
| A | CYS52 |
| A | VAL53 |
| A | LEU72 |
| A | GLU73 |
| A | LYS74 |
| A | ALA79 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residue THG A 902 |
| Chain | Residue |
| A | PHE530 |
| A | ILE560 |
| A | GLU573 |
| A | THR575 |
| A | ILE587 |
| A | PHE649 |
| A | LEU650 |
| A | TYR669 |
| A | GLU676 |
| A | TYR678 |
| A | PHE717 |
| A | TYR737 |
| A | THR843 |
| A | HOH1057 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | binding site for residue THG B 902 |
| Chain | Residue |
| B | PHE530 |
| B | ILE560 |
| B | GLU573 |
| B | THR575 |
| B | ILE587 |
| B | PHE649 |
| B | LEU650 |
| B | TYR669 |
| B | GLU676 |
| B | TYR678 |
| B | PHE717 |
| B | TYR737 |
| site_id | AC4 |
| Number of Residues | 37 |
| Details | binding site for FAD B 901 |
| Chain | Residue |
| B | GLY49 |
| B | GLY51 |
| B | CYS52 |
| B | VAL53 |
| B | LEU72 |
| B | GLU73 |
| B | LYS74 |
| B | GLY80 |
| B | SER81 |
| B | THR82 |
| B | HIS84 |
| B | ALA85 |
| B | ALA86 |
| B | GLY87 |
| B | LEU88 |
| B | PRO211 |
| B | VAL212 |
| B | ALA240 |
| B | ALA241 |
| B | GLY242 |
| B | TRP244 |
| B | HIS263 |
| B | TYR265 |
| B | GLY363 |
| B | PRO364 |
| B | ILE365 |
| B | PHE390 |
| B | TYR392 |
| B | GLY393 |
| B | ILE394 |
| B | ILE395 |
| B | HOH1008 |
| B | HOH1017 |
| B | HOH1037 |
| B | HOH1048 |
| B | HOH1086 |
| B | HOH1093 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI5 |
| Number of Residues | 32 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24858690","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4P9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PAA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PAB","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24858690","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4P9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PAB","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24858690","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4PAA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PAB","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24858690","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4PAA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Tele-8alpha-FAD histidine","evidences":[{"source":"PubMed","id":"24858690","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"4055729","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4P9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PAA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PAB","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 12 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9DBT9","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 12 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9DBT9","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q9DBT9","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
