4P6H
Tl+-bound inward-facing state (bound conformation) of the glutamate transporter homologue GltPh
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005283 | molecular_function | amino acid:sodium symporter activity |
A | 0005886 | cellular_component | plasma membrane |
A | 0006865 | biological_process | amino acid transport |
A | 0015108 | molecular_function | chloride transmembrane transporter activity |
A | 0015183 | molecular_function | L-aspartate transmembrane transporter activity |
A | 0015293 | molecular_function | symporter activity |
A | 0015501 | molecular_function | glutamate:sodium symporter activity |
A | 0016020 | cellular_component | membrane |
A | 0035725 | biological_process | sodium ion transmembrane transport |
A | 0042802 | molecular_function | identical protein binding |
A | 0046872 | molecular_function | metal ion binding |
A | 0046942 | biological_process | carboxylic acid transport |
A | 0070207 | biological_process | protein homotrimerization |
A | 0070778 | biological_process | L-aspartate transmembrane transport |
A | 0140009 | biological_process | L-aspartate import across plasma membrane |
A | 1902476 | biological_process | chloride transmembrane transport |
B | 0005283 | molecular_function | amino acid:sodium symporter activity |
B | 0005886 | cellular_component | plasma membrane |
B | 0006865 | biological_process | amino acid transport |
B | 0015108 | molecular_function | chloride transmembrane transporter activity |
B | 0015183 | molecular_function | L-aspartate transmembrane transporter activity |
B | 0015293 | molecular_function | symporter activity |
B | 0015501 | molecular_function | glutamate:sodium symporter activity |
B | 0016020 | cellular_component | membrane |
B | 0035725 | biological_process | sodium ion transmembrane transport |
B | 0042802 | molecular_function | identical protein binding |
B | 0046872 | molecular_function | metal ion binding |
B | 0046942 | biological_process | carboxylic acid transport |
B | 0070207 | biological_process | protein homotrimerization |
B | 0070778 | biological_process | L-aspartate transmembrane transport |
B | 0140009 | biological_process | L-aspartate import across plasma membrane |
B | 1902476 | biological_process | chloride transmembrane transport |
C | 0005283 | molecular_function | amino acid:sodium symporter activity |
C | 0005886 | cellular_component | plasma membrane |
C | 0006865 | biological_process | amino acid transport |
C | 0015108 | molecular_function | chloride transmembrane transporter activity |
C | 0015183 | molecular_function | L-aspartate transmembrane transporter activity |
C | 0015293 | molecular_function | symporter activity |
C | 0015501 | molecular_function | glutamate:sodium symporter activity |
C | 0016020 | cellular_component | membrane |
C | 0035725 | biological_process | sodium ion transmembrane transport |
C | 0042802 | molecular_function | identical protein binding |
C | 0046872 | molecular_function | metal ion binding |
C | 0046942 | biological_process | carboxylic acid transport |
C | 0070207 | biological_process | protein homotrimerization |
C | 0070778 | biological_process | L-aspartate transmembrane transport |
C | 0140009 | biological_process | L-aspartate import across plasma membrane |
C | 1902476 | biological_process | chloride transmembrane transport |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 3 |
Details | binding site for residue HG A 501 |
Chain | Residue |
A | CYS55 |
A | CYS364 |
A | LEU374 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue TL A 502 |
Chain | Residue |
A | GLY306 |
A | ASN310 |
A | MET311 |
A | ASN401 |
A | ASP405 |
site_id | AC3 |
Number of Residues | 6 |
Details | binding site for residue TL A 503 |
Chain | Residue |
A | ILE309 |
A | SER349 |
A | ILE350 |
A | GLY351 |
A | THR352 |
A | THR308 |
site_id | AC4 |
Number of Residues | 3 |
Details | binding site for residue HG B 501 |
Chain | Residue |
B | CYS55 |
B | CYS364 |
B | LEU374 |
site_id | AC5 |
Number of Residues | 5 |
Details | binding site for residue TL B 502 |
Chain | Residue |
B | GLY306 |
B | ASN310 |
B | MET311 |
B | ASN401 |
B | ASP405 |
site_id | AC6 |
Number of Residues | 6 |
Details | binding site for residue TL B 503 |
Chain | Residue |
B | THR308 |
B | ILE309 |
B | SER349 |
B | ILE350 |
B | GLY351 |
B | THR352 |
site_id | AC7 |
Number of Residues | 3 |
Details | binding site for residue HG C 501 |
Chain | Residue |
C | CYS55 |
C | CYS364 |
C | LEU374 |
site_id | AC8 |
Number of Residues | 5 |
Details | binding site for residue TL C 502 |
Chain | Residue |
C | GLY306 |
C | ASN310 |
C | MET311 |
C | ASN401 |
C | ASP405 |
site_id | AC9 |
Number of Residues | 6 |
Details | binding site for residue TL C 503 |
Chain | Residue |
C | THR308 |
C | ILE309 |
C | SER349 |
C | ILE350 |
C | GLY351 |
C | THR352 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 231 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:15483603 |
Chain | Residue | Details |
A | MET1-PRO11 | |
B | LYS290-GLY297 | |
C | MET1-PRO11 | |
C | PHE63-ARG80 | |
C | LEU161-LYS196 | |
C | LYS252-SER260 | |
C | LYS290-GLY297 | |
A | PHE63-ARG80 | |
A | LEU161-LYS196 | |
A | LYS252-SER260 | |
A | LYS290-GLY297 | |
B | MET1-PRO11 | |
B | PHE63-ARG80 | |
B | LEU161-LYS196 | |
B | LYS252-SER260 |
site_id | SWS_FT_FI2 |
Number of Residues | 54 |
Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:15483603 |
Chain | Residue | Details |
A | VAL12-LEU30 | |
B | VAL12-LEU30 | |
C | VAL12-LEU30 |
site_id | SWS_FT_FI3 |
Number of Residues | 216 |
Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:15483603 |
Chain | Residue | Details |
A | GLY31-THR41 | |
B | PRO373-ALA391 | |
C | GLY31-THR41 | |
C | ALA104-GLN121 | |
C | GLU219-LYS230 | |
C | ALA321-GLN337 | |
C | PRO373-ALA391 | |
A | ALA104-GLN121 | |
A | GLU219-LYS230 | |
A | ALA321-GLN337 | |
A | PRO373-ALA391 | |
B | GLY31-THR41 | |
B | ALA104-GLN121 | |
B | GLU219-LYS230 | |
B | ALA321-GLN337 |
site_id | SWS_FT_FI4 |
Number of Residues | 60 |
Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:15483603 |
Chain | Residue | Details |
A | TYR42-VAL62 | |
B | TYR42-VAL62 | |
C | TYR42-VAL62 |
site_id | SWS_FT_FI5 |
Number of Residues | 66 |
Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:15483603 |
Chain | Residue | Details |
A | VAL81-MET103 | |
B | VAL81-MET103 | |
C | VAL81-MET103 |
site_id | SWS_FT_FI6 |
Number of Residues | 114 |
Details | TRANSMEM: Discontinuously helical; Name=4 => ECO:0000269|PubMed:15483603 |
Chain | Residue | Details |
A | PHE122-ILE160 | |
B | PHE122-ILE160 | |
C | PHE122-ILE160 |
site_id | SWS_FT_FI7 |
Number of Residues | 63 |
Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:15483603 |
Chain | Residue | Details |
A | ILE197-ALA218 | |
B | ILE197-ALA218 | |
C | ILE197-ALA218 |
site_id | SWS_FT_FI8 |
Number of Residues | 60 |
Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:15483603 |
Chain | Residue | Details |
A | VAL231-LEU251 | |
B | VAL231-LEU251 | |
C | VAL231-LEU251 |
site_id | SWS_FT_FI9 |
Number of Residues | 186 |
Details | INTRAMEM: Discontinuously helical => ECO:0000269|PubMed:15483603 |
Chain | Residue | Details |
A | PHE261-ALA289 | |
A | GLN338-LEU372 | |
B | PHE261-ALA289 | |
B | GLN338-LEU372 | |
C | PHE261-ALA289 | |
C | GLN338-LEU372 |
site_id | SWS_FT_FI10 |
Number of Residues | 66 |
Details | TRANSMEM: Discontinuously helical; Name=7 => ECO:0000269|PubMed:15483603 |
Chain | Residue | Details |
A | ILE298-VAL320 | |
B | ILE298-VAL320 | |
C | ILE298-VAL320 |
site_id | SWS_FT_FI11 |
Number of Residues | 60 |
Details | TRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:15483603 |
Chain | Residue | Details |
A | ILE392-VAL412 | |
B | ILE392-VAL412 | |
C | ILE392-VAL412 |
site_id | SWS_FT_FI12 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:17230192, ECO:0007744|PDB:2NWL, ECO:0007744|PDB:2NWX, ECO:0007744|PDB:3KBC |
Chain | Residue | Details |
A | ARG276 | |
C | THR314 | |
C | VAL355 | |
C | ASP394 | |
A | THR314 | |
A | VAL355 | |
A | ASP394 | |
B | ARG276 | |
B | THR314 | |
B | VAL355 | |
B | ASP394 | |
C | ARG276 |
site_id | SWS_FT_FI13 |
Number of Residues | 15 |
Details | BINDING: BINDING => ECO:0000305|PubMed:17230192, ECO:0007744|PDB:2NWX |
Chain | Residue | Details |
A | GLY306 | |
B | ASP405 | |
C | GLY306 | |
C | THR308 | |
C | THR352 | |
C | ASN401 | |
C | ASP405 | |
A | THR308 | |
A | THR352 | |
A | ASN401 | |
A | ASP405 | |
B | GLY306 | |
B | THR308 | |
B | THR352 | |
B | ASN401 |
site_id | SWS_FT_FI14 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000305|PubMed:17230192, ECO:0007744|PDB:2NWX, ECO:0007744|PDB:4X2S |
Chain | Residue | Details |
A | ASN310 | |
B | ASN310 | |
C | ASN310 |