4P5D
CRYSTAL STRUCTURE OF RAT DNPH1 (RCL) WITH 6-NAPHTHYL-PURINE-RIBOSIDE-MONOPHOSPHATE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0009159 | biological_process | deoxyribonucleoside monophosphate catabolic process |
| A | 0070694 | molecular_function | 5-hydroxymethyl-dUMP N-hydrolase activity |
| C | 0009159 | biological_process | deoxyribonucleoside monophosphate catabolic process |
| C | 0070694 | molecular_function | 5-hydroxymethyl-dUMP N-hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | binding site for residue N6P C 201 |
| Chain | Residue |
| C | TYR13 |
| C | ALA58 |
| C | ILE65 |
| C | ASN69 |
| C | SER87 |
| C | GLY89 |
| C | GLU93 |
| C | SER117 |
| C | MET119 |
| C | HOH304 |
| C | HOH306 |
| C | CYS15 |
| C | HOH330 |
| C | HOH344 |
| C | GLY16 |
| C | SER17 |
| C | ILE18 |
| C | ARG19 |
| C | GLY20 |
| C | HIS45 |
| C | GLU57 |
| site_id | AC2 |
| Number of Residues | 23 |
| Details | binding site for residue N6P A 201 |
| Chain | Residue |
| A | TYR13 |
| A | CYS15 |
| A | GLY16 |
| A | SER17 |
| A | ILE18 |
| A | ARG19 |
| A | GLY20 |
| A | HIS45 |
| A | VAL46 |
| A | GLU57 |
| A | ALA58 |
| A | ILE65 |
| A | ASN69 |
| A | SER87 |
| A | GLY89 |
| A | VAL90 |
| A | GLU93 |
| A | SER117 |
| A | MET119 |
| A | HOH305 |
| A | HOH315 |
| A | HOH369 |
| A | HOH385 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 202 |
| Chain | Residue |
| A | ARG34 |
| A | ARG36 |
| A | ARG37 |
| A | HOH304 |
| A | HOH317 |
| A | HOH382 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23385460, ECO:0000269|PubMed:24260472, ECO:0000269|PubMed:25108359, ECO:0007744|PDB:4FYH, ECO:0007744|PDB:4FYI, ECO:0007744|PDB:4FYK, ECO:0007744|PDB:4KXL, ECO:0007744|PDB:4KXM, ECO:0007744|PDB:4KXN, ECO:0007744|PDB:4P5D |
| Chain | Residue | Details |
| C | GLY16 | |
| A | ARG19 | |
| A | GLY20 | |
| A | SER87 | |
| A | GLY89 | |
| A | GLU93 | |
| C | ILE18 | |
| C | ARG19 | |
| C | GLY20 | |
| C | SER87 | |
| C | GLY89 | |
| C | GLU93 | |
| A | GLY16 | |
| A | ILE18 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: in other chain => ECO:0000269|PubMed:23385460, ECO:0000269|PubMed:24260472, ECO:0000269|PubMed:25108359, ECO:0007744|PDB:4FYH, ECO:0007744|PDB:4FYI, ECO:0007744|PDB:4FYK, ECO:0007744|PDB:4KXL, ECO:0007744|PDB:4KXM, ECO:0007744|PDB:4KXN, ECO:0007744|PDB:4P5D |
| Chain | Residue | Details |
| C | SER117 | |
| A | SER117 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O43598 |
| Chain | Residue | Details |
| C | SER17 | |
| C | SER87 | |
| C | SER112 | |
| C | SER127 | |
| A | SER17 | |
| A | SER87 | |
| A | SER112 | |
| A | SER127 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903 |
| Chain | Residue | Details |
| C | SER117 | |
| A | SER117 |
