4P4G
Crystal Structure of Mycobacterium tuberculosis Shikimate Dehydrogenase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004764 | molecular_function | shikimate 3-dehydrogenase (NADP+) activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0009423 | biological_process | chorismate biosynthetic process |
| A | 0019632 | biological_process | shikimate metabolic process |
| A | 0050661 | molecular_function | NADP binding |
| B | 0004764 | molecular_function | shikimate 3-dehydrogenase (NADP+) activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| B | 0009423 | biological_process | chorismate biosynthetic process |
| B | 0019632 | biological_process | shikimate metabolic process |
| B | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue SKM A 301 |
| Chain | Residue |
| A | SER18 |
| A | GLN243 |
| A | GLN247 |
| A | HOH507 |
| A | SER20 |
| A | SER63 |
| A | VAL64 |
| A | THR65 |
| A | LYS69 |
| A | ASN90 |
| A | ASP105 |
| A | TYR215 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue BR A 302 |
| Chain | Residue |
| A | PRO67 |
| A | LYS69 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue BR A 303 |
| Chain | Residue |
| A | LYS7 |
| A | GLY56 |
| A | HOH425 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue BR A 304 |
| Chain | Residue |
| A | ARG149 |
| B | ARG100 |
| B | HOH479 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue BR A 305 |
| Chain | Residue |
| A | ALA179 |
| A | HOH577 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue BR A 306 |
| Chain | Residue |
| A | ARG100 |
| A | HOH454 |
| A | HOH595 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue BR A 307 |
| Chain | Residue |
| A | SER235 |
| A | GLN238 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 308 |
| Chain | Residue |
| A | GLY124 |
| A | SER125 |
| A | ALA148 |
| A | ARG149 |
| A | ASN150 |
| A | HOH534 |
| A | HOH627 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 309 |
| Chain | Residue |
| A | ASP152 |
| A | LYS153 |
| A | ARG156 |
| A | HOH560 |
| A | HOH612 |
| B | ARG94 |
| B | TRP99 |
| B | HOH529 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue BR B 301 |
| Chain | Residue |
| B | SER18 |
| B | SER20 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 302 |
| Chain | Residue |
| B | GLY124 |
| B | SER125 |
| B | ALA148 |
| B | ARG149 |
| B | ASN150 |
