4P3W
Crystal structure of the human filamin A Ig-like domains 20-21 in complex with migfilin peptide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0030036 | biological_process | actin cytoskeleton organization |
| A | 0051015 | molecular_function | actin filament binding |
| B | 0030036 | biological_process | actin cytoskeleton organization |
| B | 0051015 | molecular_function | actin filament binding |
| C | 0030036 | biological_process | actin cytoskeleton organization |
| C | 0051015 | molecular_function | actin filament binding |
| D | 0030036 | biological_process | actin cytoskeleton organization |
| D | 0051015 | molecular_function | actin filament binding |
| E | 0030036 | biological_process | actin cytoskeleton organization |
| E | 0051015 | molecular_function | actin filament binding |
| F | 0030036 | biological_process | actin cytoskeleton organization |
| F | 0051015 | molecular_function | actin filament binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 A 2401 |
| Chain | Residue |
| A | PRO2232 |
| A | LEU2233 |
| A | GLY2234 |
| A | GLU2235 |
| A | GLY2236 |
| A | GLY2237 |
| A | ALA2238 |
| A | PHE2311 |
| A | ASN2312 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue PR A 2402 |
| Chain | Residue |
| A | ASP2173 |
| B | SER2329 |
| B | HOH2503 |
| B | HOH2507 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 B 2401 |
| Chain | Residue |
| B | PRO2232 |
| B | LEU2233 |
| B | GLY2234 |
| B | GLU2235 |
| B | GLY2236 |
| B | GLY2237 |
| B | ALA2238 |
| B | ASN2312 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue PR B 2402 |
| Chain | Residue |
| A | SER2329 |
| A | HOH2520 |
| B | ASP2173 |
| B | HOH2504 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 E 2401 |
| Chain | Residue |
| E | PRO2232 |
| E | LEU2233 |
| E | GLY2234 |
| E | GLU2235 |
| E | GLY2236 |
| E | GLY2237 |
| E | ALA2238 |
| E | PHE2311 |
| E | ASN2312 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | binding site for residue NA E 2402 |
| Chain | Residue |
| E | ASP2173 |
| E | ASP2173 |
| E | ASP2173 |
| E | HOH2511 |
| E | HOH2511 |
| E | HOH2511 |
| E | HOH2516 |
| E | HOH2516 |
| E | HOH2516 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue PR E 2403 |
| Chain | Residue |
| E | GLU2306 |
| E | HOH2503 |
| F | GLU2276 |
| F | GLU2306 |
| F | HOH2502 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue PR D 2401 |
| Chain | Residue |
| C | GLU2306 |
| C | HOH2517 |
| D | GLU2276 |
| D | GLU2306 |
| D | HOH2506 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 C 2401 |
| Chain | Residue |
| C | PRO2232 |
| C | LEU2233 |
| C | GLY2234 |
| C | GLU2235 |
| C | GLY2236 |
| C | GLY2237 |
| C | ALA2238 |
| C | PHE2311 |
| C | ASN2312 |
| site_id | AD1 |
| Number of Residues | 9 |
| Details | binding site for residue NA C 2402 |
| Chain | Residue |
| C | ASP2173 |
| C | ASP2173 |
| C | ASP2173 |
| C | HOH2502 |
| C | HOH2502 |
| C | HOH2502 |
| C | HOH2511 |
| C | HOH2511 |
| C | HOH2511 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:25666618, ECO:0000269|PubMed:26460884, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18088087, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER2152 | |
| B | SER2152 | |
| E | SER2152 | |
| F | SER2152 | |
| D | SER2152 | |
| C | SER2152 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18088087, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER2158 | |
| B | SER2158 | |
| E | SER2158 | |
| F | SER2158 | |
| D | SER2158 | |
| C | SER2158 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER2163 | |
| B | SER2163 | |
| E | SER2163 | |
| F | SER2163 | |
| D | SER2163 | |
| C | SER2163 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8BTM8 |
| Chain | Residue | Details |
| A | SER2180 | |
| D | SER2329 | |
| C | SER2180 | |
| C | SER2329 | |
| A | SER2329 | |
| B | SER2180 | |
| B | SER2329 | |
| E | SER2180 | |
| E | SER2329 | |
| F | SER2180 | |
| F | SER2329 | |
| D | SER2180 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER2284 | |
| B | SER2284 | |
| E | SER2284 | |
| F | SER2284 | |
| D | SER2284 | |
| C | SER2284 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER2327 | |
| B | SER2327 | |
| E | SER2327 | |
| F | SER2327 | |
| D | SER2327 | |
| C | SER2327 |
