4P2F

Monomeric form of a single mutant (F363R) of Mycobacterial Adenylyl cyclase Rv1625c

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0009190	biological_process	cyclic nucleotide biosynthetic process
A	0016849	molecular_function	phosphorus-oxygen lyase activity
A	0035556	biological_process	intracellular signal transduction

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue EDO A 501

Chain	Residue
A	ILE243
A	ALA244
A	ASP245
A	ARG278

---

site_id	AC2
Number of Residues	6
Details	binding site for residue EDO A 502

Chain	Residue
A	HOH684
A	SER306
A	GLY307
A	VAL308
A	PRO309
A	ARG310

---

site_id	AC3
Number of Residues	6
Details	binding site for residue EDO A 503

Chain	Residue
A	LEU324
A	THR327
A	ASN328
A	GLY384
A	GLN385
A	ILE422

---

site_id	AC4
Number of Residues	7
Details	binding site for residue EDO A 504

Chain	Residue
A	ARG278
A	PRO309
A	LEU333
A	LYS334
A	EDO507
A	HOH606
A	HOH645

---

site_id	AC5
Number of Residues	3
Details	binding site for residue EDO A 505

Chain	Residue
A	ASP256
A	GLY259
A	GLU285

---

site_id	AC6
Number of Residues	5
Details	binding site for residue EDO A 506

Chain	Residue
A	ASP288
A	GLN289
A	GLY291
A	ARG344
A	SER379

---

site_id	AC7
Number of Residues	8
Details	binding site for residue EDO A 507

Chain	Residue
A	ALA244
A	ASP245
A	TYR247
A	ARG278
A	ALA354
A	GLY355
A	TYR364
A	EDO504

---

site_id	AC8
Number of Residues	4
Details	binding site for residue EDO A 508

Chain	Residue
A	LYS246
A	TYR247
A	ASP248
A	HOH691

---

site_id	AC9
Number of Residues	4
Details	binding site for residue EDO A 509

Chain	Residue
A	ASP284
A	ASP288
A	HOH615
A	HOH658

---

site_id	AD1
Number of Residues	5
Details	binding site for residue EDO A 510

Chain	Residue
A	ARG376
A	PRO389
A	ASP390
A	ARG417
A	HOH631

---

site_id	AD2
Number of Residues	3
Details	binding site for residue EDO A 511

Chain	Residue
A	PRO311
A	ARG376
A	HOH610

---

site_id	AD3
Number of Residues	4
Details	binding site for residue EDO A 512

Chain	Residue
A	ARG310
A	PRO311
A	ARG312
A	HOH684

---

site_id	AD4
Number of Residues	6
Details	binding site for residue EDO A 513

Chain	Residue
A	TYR393
A	LYS397
A	PHE400
A	VAL401
A	LEU402
A	HOH657

---

site_id	AD5
Number of Residues	5
Details	binding site for residue EDO A 514

Chain	Residue
A	GLN387
A	ARG405
A	GLY406
A	MET416
A	THR418

---

site_id	AD6
Number of Residues	7
Details	binding site for residue EDO A 515

Chain	Residue
A	VAL297
A	MET303
A	ARG337
A	ASP365
A	VAL366
A	VAL371
A	HOH623

---

site_id	AD7
Number of Residues	5
Details	binding site for residue EDO A 516

Chain	Residue
A	GLU239
A	ASN241
A	ASP335
A	ASN339
A	EDO518

---

site_id	AD8
Number of Residues	6
Details	binding site for residue EDO A 517

Chain	Residue
A	ASP277
A	TYR280
A	SER281
A	ASP284
A	LYS294
A	HOH677

---

site_id	AD9
Number of Residues	4
Details	binding site for residue EDO A 518

Chain	Residue
A	ASN241
A	ARG337
A	TRP367
A	EDO516

---

site_id	AE1
Number of Residues	6
Details	binding site for residue PEG A 519

Chain	Residue
A	GLN289
A	HIS290
A	ARG344
A	SER379
A	ASP381
A	HOH607

---

site_id	AE2
Number of Residues	3
Details	binding site for residue GOL A 520

Chain	Residue
A	GLY423
A	ARG424
A	ASN328

---

Functional Information from PROSITE/UniProt

site_id	PS00452
Number of Residues	24
Details	GUANYLATE_CYCLASE_1 Guanylate cyclase signature. GVV.GsrrfrYdVWGDAVNvasrmE

Chain	Residue	Details
A	GLY355-GLU378

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000305|PubMed:11447108

Chain	Residue	Details
A	ASP256
A	ASP300

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