4P10
pro-carboxypeptidase U In Complex With 5-(3-aminopropyl)-1-propyl-6,7-dihydro-4H-benzimidazole-5-carboxylic acid
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003331 | biological_process | positive regulation of extracellular matrix constituent secretion |
| A | 0004180 | molecular_function | carboxypeptidase activity |
| A | 0004181 | molecular_function | metallocarboxypeptidase activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006508 | biological_process | proteolysis |
| A | 0007596 | biological_process | blood coagulation |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0009410 | biological_process | response to xenobiotic stimulus |
| A | 0010757 | biological_process | negative regulation of plasminogen activation |
| A | 0030163 | biological_process | protein catabolic process |
| A | 0042730 | biological_process | fibrinolysis |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051918 | biological_process | negative regulation of fibrinolysis |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0071333 | biological_process | cellular response to glucose stimulus |
| A | 0097421 | biological_process | liver regeneration |
| A | 2000346 | biological_process | negative regulation of hepatocyte proliferation |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000255|PROSITE-ProRule:PRU01379 |
| Chain | Residue | Details |
| A | GLU385 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01379, ECO:0000269|PubMed:18559974, ECO:0000269|PubMed:20088943 |
| Chain | Residue | Details |
| A | HIS181 | |
| A | GLU184 | |
| A | HIS310 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P00730 |
| Chain | Residue | Details |
| A | ARG239 | |
| A | ASN256 | |
| A | SER311 | |
| A | TYR363 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by thrombin |
| Chain | Residue | Details |
| A | ARG324 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:16445295, ECO:0000269|PubMed:18559974 |
| Chain | Residue | Details |
| A | ASN44 | |
| A | ASN73 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16445295, ECO:0000269|PubMed:18559974 |
| Chain | Residue | Details |
| A | ASN85 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:16445295, ECO:0000269|PubMed:18559974, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:22171320 |
| Chain | Residue | Details |
| A | ASN108 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine; partial => ECO:0000269|PubMed:16445295 |
| Chain | Residue | Details |
| A | ASN241 |
