4OYN

Fifteen minutes iron loaded human H ferritin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004322	molecular_function	ferroxidase activity
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005776	cellular_component	autophagosome
A	0005829	cellular_component	cytosol
A	0006826	biological_process	iron ion transport
A	0006879	biological_process	intracellular iron ion homeostasis
A	0006955	biological_process	immune response
A	0008198	molecular_function	ferrous iron binding
A	0008199	molecular_function	ferric iron binding
A	0008285	biological_process	negative regulation of cell population proliferation
A	0016491	molecular_function	oxidoreductase activity
A	0031410	cellular_component	cytoplasmic vesicle
A	0042802	molecular_function	identical protein binding
A	0044754	cellular_component	autolysosome
A	0046872	molecular_function	metal ion binding
A	0048147	biological_process	negative regulation of fibroblast proliferation
A	0070062	cellular_component	extracellular exosome
A	0070288	cellular_component	ferritin complex
A	0110076	biological_process	negative regulation of ferroptosis
A	0140315	molecular_function	iron ion sequestering activity
A	1904724	cellular_component	tertiary granule lumen
A	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue TRS A 201

Chain	Residue
A	HIS128
A	HOH309
A	HOH335
A	HOH357
A	HOH366
A	HOH542
A	ASP131
A	PHE132
A	THR135
A	HIS136
A	ASN139
A	CL218
A	MG223
A	HOH304

---

site_id	AC2
Number of Residues	10
Details	binding site for residue BCN A 202

Chain	Residue
A	LEU28
A	LEU28
A	SER31
A	SER31
A	TYR32
A	LEU35
A	ARG63
A	ARG63
A	ILE85
A	ILE85

---

site_id	AC3
Number of Residues	7
Details	binding site for residue FE A 203

Chain	Residue
A	GLU27
A	GLU62
A	HIS65
A	FE204
A	HOH445
A	HOH601
A	HOH611

---

site_id	AC4
Number of Residues	7
Details	binding site for residue FE A 204

Chain	Residue
A	GLU62
A	GLU107
A	GLN141
A	FE203
A	HOH445
A	HOH489
A	HOH611

---

site_id	AC5
Number of Residues	6
Details	binding site for residue FE A 205

Chain	Residue
A	GLN58
A	GLU61
A	HOH494
A	HOH599
A	HOH605
A	HOH613

---

site_id	AC6
Number of Residues	6
Details	binding site for residue FE A 206

Chain	Residue
A	HIS57
A	GLU61
A	HOH597
A	HOH603
A	HOH606
A	HOH612

---

site_id	AC7
Number of Residues	12
Details	binding site for residue FE A 207

Chain	Residue
A	HIS173
A	HIS173
A	HIS173
A	HIS173
A	CL210
A	CL210
A	CL210
A	CL210
A	HOH386
A	HOH386
A	HOH386
A	HOH386

---

site_id	AC8
Number of Residues	6
Details	binding site for residue FE A 208

Chain	Residue
A	HOH319
A	HOH319
A	HOH319
A	HOH405
A	HOH405
A	HOH405

---

site_id	AC9
Number of Residues	9
Details	binding site for residue FE A 209

Chain	Residue
A	ASP131
A	ASP131
A	ASP131
A	HOH315
A	HOH315
A	HOH315
A	HOH324
A	HOH324
A	HOH324

---

site_id	AD1
Number of Residues	8
Details	binding site for residue CL A 210

Chain	Residue
A	HIS173
A	HIS173
A	HIS173
A	HIS173
A	FE207
A	FE207
A	FE207
A	FE207

---

site_id	AD2
Number of Residues	2
Details	binding site for residue CL A 211

Chain	Residue
A	HIS13
A	GLN14

---

site_id	AD3
Number of Residues	5
Details	binding site for residue CL A 212

Chain	Residue
A	GLN83
A	ASP84
A	LYS86
A	CL221
A	HOH420

---

site_id	AD4
Number of Residues	4
Details	binding site for residue CL A 213

Chain	Residue
A	ASN125
A	HOH314
A	HOH352
A	HOH425

---

site_id	AD5
Number of Residues	3
Details	binding site for residue CL A 214

Chain	Residue
A	ASN21
A	HOH471
A	HOH518

---

site_id	AD6
Number of Residues	3
Details	binding site for residue CL A 215

Chain	Residue
A	ARG9
A	ASN11
A	TYR12

---

site_id	AD7
Number of Residues	4
Details	binding site for residue CL A 216

Chain	Residue
A	GLN75
A	HOH332
A	HOH383
A	HOH584

---

site_id	AD8
Number of Residues	5
Details	binding site for residue CL A 217

Chain	Residue
A	ASP150
A	HIS151
A	ASN154
A	HOH308
A	HOH432

---

site_id	AD9
Number of Residues	3
Details	binding site for residue CL A 218

Chain	Residue
A	GLN75
A	ASN139
A	TRS201

---

site_id	AE1
Number of Residues	1
Details	binding site for residue CL A 219

Chain	Residue
A	ASN11

---

site_id	AE2
Number of Residues	6
Details	binding site for residue CL A 220

Chain	Residue
A	GLU134
A	THR135
A	HIS136
A	TYR137
A	ASN139
A	GLU140

---

site_id	AE3
Number of Residues	3
Details	binding site for residue CL A 221

Chain	Residue
A	LYS86
A	CL212
A	HOH343

---

site_id	AE4
Number of Residues	4
Details	binding site for residue CL A 222

Chain	Residue
A	ASN25
A	HOH563
A	HOH564
A	HOH602

---

site_id	AE5
Number of Residues	6
Details	binding site for residue MG A 223

Chain	Residue
A	TRS201
A	HOH335
A	HOH357
A	HOH366
A	HOH370
A	HOH553

---

site_id	AE6
Number of Residues	6
Details	binding site for residue MG A 224

Chain	Residue
A	HOH446
A	HOH456
A	HOH543
A	HOH544
A	HOH602
A	HOH607

---

site_id	AE7
Number of Residues	8
Details	binding site for residue MG A 225

Chain	Residue
A	HOH305
A	HOH305
A	HOH313
A	HOH313
A	HOH420
A	HOH420
A	HOH437
A	HOH437

---

Functional Information from PROSITE/UniProt

site_id	PS00204
Number of Residues	21
Details	FERRITIN_2 Ferritin iron-binding regions signature 2. DphLCDFIEthYLneqvkaIK

Chain	Residue	Details
A	ASP126-LYS146

---

site_id	PS00540
Number of Residues	19
Details	FERRITIN_1 Ferritin iron-binding regions signature 1. EeREhaEKLMklQNqRgGR

Chain	Residue	Details
A	GLU61-ARG79

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	149
Details	Domain: {"description":"Ferritin-like diiron","evidences":[{"source":"PROSITE-ProRule","id":"PRU00085","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"1992356","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FHA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00085","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Essential for association with cargo receptor NCOA4","evidences":[{"source":"PubMed","id":"26436293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---