4OYE

Crystal structure of GltPh R397A in apo

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005283	molecular_function	amino acid:sodium symporter activity
A	0005886	cellular_component	plasma membrane
A	0006835	biological_process	dicarboxylic acid transport
A	0006865	biological_process	amino acid transport
A	0015108	molecular_function	chloride transmembrane transporter activity
A	0015183	molecular_function	L-aspartate transmembrane transporter activity
A	0015293	molecular_function	symporter activity
A	0015501	molecular_function	glutamate:sodium symporter activity
A	0016020	cellular_component	membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0035725	biological_process	sodium ion transmembrane transport
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0046942	biological_process	carboxylic acid transport
A	0070207	biological_process	protein homotrimerization
A	0070778	biological_process	L-aspartate transmembrane transport
A	0140009	biological_process	L-aspartate import across plasma membrane
A	1902476	biological_process	chloride transmembrane transport
B	0005283	molecular_function	amino acid:sodium symporter activity
B	0005886	cellular_component	plasma membrane
B	0006835	biological_process	dicarboxylic acid transport
B	0006865	biological_process	amino acid transport
B	0015108	molecular_function	chloride transmembrane transporter activity
B	0015183	molecular_function	L-aspartate transmembrane transporter activity
B	0015293	molecular_function	symporter activity
B	0015501	molecular_function	glutamate:sodium symporter activity
B	0016020	cellular_component	membrane
B	0022857	molecular_function	transmembrane transporter activity
B	0035725	biological_process	sodium ion transmembrane transport
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0046942	biological_process	carboxylic acid transport
B	0070207	biological_process	protein homotrimerization
B	0070778	biological_process	L-aspartate transmembrane transport
B	0140009	biological_process	L-aspartate import across plasma membrane
B	1902476	biological_process	chloride transmembrane transport
C	0005283	molecular_function	amino acid:sodium symporter activity
C	0005886	cellular_component	plasma membrane
C	0006835	biological_process	dicarboxylic acid transport
C	0006865	biological_process	amino acid transport
C	0015108	molecular_function	chloride transmembrane transporter activity
C	0015183	molecular_function	L-aspartate transmembrane transporter activity
C	0015293	molecular_function	symporter activity
C	0015501	molecular_function	glutamate:sodium symporter activity
C	0016020	cellular_component	membrane
C	0022857	molecular_function	transmembrane transporter activity
C	0035725	biological_process	sodium ion transmembrane transport
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0046942	biological_process	carboxylic acid transport
C	0070207	biological_process	protein homotrimerization
C	0070778	biological_process	L-aspartate transmembrane transport
C	0140009	biological_process	L-aspartate import across plasma membrane
C	1902476	biological_process	chloride transmembrane transport
D	0005283	molecular_function	amino acid:sodium symporter activity
D	0005886	cellular_component	plasma membrane
D	0006835	biological_process	dicarboxylic acid transport
D	0006865	biological_process	amino acid transport
D	0015108	molecular_function	chloride transmembrane transporter activity
D	0015183	molecular_function	L-aspartate transmembrane transporter activity
D	0015293	molecular_function	symporter activity
D	0015501	molecular_function	glutamate:sodium symporter activity
D	0016020	cellular_component	membrane
D	0022857	molecular_function	transmembrane transporter activity
D	0035725	biological_process	sodium ion transmembrane transport
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
D	0046942	biological_process	carboxylic acid transport
D	0070207	biological_process	protein homotrimerization
D	0070778	biological_process	L-aspartate transmembrane transport
D	0140009	biological_process	L-aspartate import across plasma membrane
D	1902476	biological_process	chloride transmembrane transport
E	0005283	molecular_function	amino acid:sodium symporter activity
E	0005886	cellular_component	plasma membrane
E	0006835	biological_process	dicarboxylic acid transport
E	0006865	biological_process	amino acid transport
E	0015108	molecular_function	chloride transmembrane transporter activity
E	0015183	molecular_function	L-aspartate transmembrane transporter activity
E	0015293	molecular_function	symporter activity
E	0015501	molecular_function	glutamate:sodium symporter activity
E	0016020	cellular_component	membrane
E	0022857	molecular_function	transmembrane transporter activity
E	0035725	biological_process	sodium ion transmembrane transport
E	0042802	molecular_function	identical protein binding
E	0046872	molecular_function	metal ion binding
E	0046942	biological_process	carboxylic acid transport
E	0070207	biological_process	protein homotrimerization
E	0070778	biological_process	L-aspartate transmembrane transport
E	0140009	biological_process	L-aspartate import across plasma membrane
E	1902476	biological_process	chloride transmembrane transport
F	0005283	molecular_function	amino acid:sodium symporter activity
F	0005886	cellular_component	plasma membrane
F	0006835	biological_process	dicarboxylic acid transport
F	0006865	biological_process	amino acid transport
F	0015108	molecular_function	chloride transmembrane transporter activity
F	0015183	molecular_function	L-aspartate transmembrane transporter activity
F	0015293	molecular_function	symporter activity
F	0015501	molecular_function	glutamate:sodium symporter activity
F	0016020	cellular_component	membrane
F	0022857	molecular_function	transmembrane transporter activity
F	0035725	biological_process	sodium ion transmembrane transport
F	0042802	molecular_function	identical protein binding
F	0046872	molecular_function	metal ion binding
F	0046942	biological_process	carboxylic acid transport
F	0070207	biological_process	protein homotrimerization
F	0070778	biological_process	L-aspartate transmembrane transport
F	0140009	biological_process	L-aspartate import across plasma membrane
F	1902476	biological_process	chloride transmembrane transport
G	0005283	molecular_function	amino acid:sodium symporter activity
G	0005886	cellular_component	plasma membrane
G	0006835	biological_process	dicarboxylic acid transport
G	0006865	biological_process	amino acid transport
G	0015108	molecular_function	chloride transmembrane transporter activity
G	0015183	molecular_function	L-aspartate transmembrane transporter activity
G	0015293	molecular_function	symporter activity
G	0015501	molecular_function	glutamate:sodium symporter activity
G	0016020	cellular_component	membrane
G	0022857	molecular_function	transmembrane transporter activity
G	0035725	biological_process	sodium ion transmembrane transport
G	0042802	molecular_function	identical protein binding
G	0046872	molecular_function	metal ion binding
G	0046942	biological_process	carboxylic acid transport
G	0070207	biological_process	protein homotrimerization
G	0070778	biological_process	L-aspartate transmembrane transport
G	0140009	biological_process	L-aspartate import across plasma membrane
G	1902476	biological_process	chloride transmembrane transport
H	0005283	molecular_function	amino acid:sodium symporter activity
H	0005886	cellular_component	plasma membrane
H	0006835	biological_process	dicarboxylic acid transport
H	0006865	biological_process	amino acid transport
H	0015108	molecular_function	chloride transmembrane transporter activity
H	0015183	molecular_function	L-aspartate transmembrane transporter activity
H	0015293	molecular_function	symporter activity
H	0015501	molecular_function	glutamate:sodium symporter activity
H	0016020	cellular_component	membrane
H	0022857	molecular_function	transmembrane transporter activity
H	0035725	biological_process	sodium ion transmembrane transport
H	0042802	molecular_function	identical protein binding
H	0046872	molecular_function	metal ion binding
H	0046942	biological_process	carboxylic acid transport
H	0070207	biological_process	protein homotrimerization
H	0070778	biological_process	L-aspartate transmembrane transport
H	0140009	biological_process	L-aspartate import across plasma membrane
H	1902476	biological_process	chloride transmembrane transport
I	0005283	molecular_function	amino acid:sodium symporter activity
I	0005886	cellular_component	plasma membrane
I	0006835	biological_process	dicarboxylic acid transport
I	0006865	biological_process	amino acid transport
I	0015108	molecular_function	chloride transmembrane transporter activity
I	0015183	molecular_function	L-aspartate transmembrane transporter activity
I	0015293	molecular_function	symporter activity
I	0015501	molecular_function	glutamate:sodium symporter activity
I	0016020	cellular_component	membrane
I	0022857	molecular_function	transmembrane transporter activity
I	0035725	biological_process	sodium ion transmembrane transport
I	0042802	molecular_function	identical protein binding
I	0046872	molecular_function	metal ion binding
I	0046942	biological_process	carboxylic acid transport
I	0070207	biological_process	protein homotrimerization
I	0070778	biological_process	L-aspartate transmembrane transport
I	0140009	biological_process	L-aspartate import across plasma membrane
I	1902476	biological_process	chloride transmembrane transport
J	0005283	molecular_function	amino acid:sodium symporter activity
J	0005886	cellular_component	plasma membrane
J	0006835	biological_process	dicarboxylic acid transport
J	0006865	biological_process	amino acid transport
J	0015108	molecular_function	chloride transmembrane transporter activity
J	0015183	molecular_function	L-aspartate transmembrane transporter activity
J	0015293	molecular_function	symporter activity
J	0015501	molecular_function	glutamate:sodium symporter activity
J	0016020	cellular_component	membrane
J	0022857	molecular_function	transmembrane transporter activity
J	0035725	biological_process	sodium ion transmembrane transport
J	0042802	molecular_function	identical protein binding
J	0046872	molecular_function	metal ion binding
J	0046942	biological_process	carboxylic acid transport
J	0070207	biological_process	protein homotrimerization
J	0070778	biological_process	L-aspartate transmembrane transport
J	0140009	biological_process	L-aspartate import across plasma membrane
J	1902476	biological_process	chloride transmembrane transport
K	0005283	molecular_function	amino acid:sodium symporter activity
K	0005886	cellular_component	plasma membrane
K	0006835	biological_process	dicarboxylic acid transport
K	0006865	biological_process	amino acid transport
K	0015108	molecular_function	chloride transmembrane transporter activity
K	0015183	molecular_function	L-aspartate transmembrane transporter activity
K	0015293	molecular_function	symporter activity
K	0015501	molecular_function	glutamate:sodium symporter activity
K	0016020	cellular_component	membrane
K	0022857	molecular_function	transmembrane transporter activity
K	0035725	biological_process	sodium ion transmembrane transport
K	0042802	molecular_function	identical protein binding
K	0046872	molecular_function	metal ion binding
K	0046942	biological_process	carboxylic acid transport
K	0070207	biological_process	protein homotrimerization
K	0070778	biological_process	L-aspartate transmembrane transport
K	0140009	biological_process	L-aspartate import across plasma membrane
K	1902476	biological_process	chloride transmembrane transport
L	0005283	molecular_function	amino acid:sodium symporter activity
L	0005886	cellular_component	plasma membrane
L	0006835	biological_process	dicarboxylic acid transport
L	0006865	biological_process	amino acid transport
L	0015108	molecular_function	chloride transmembrane transporter activity
L	0015183	molecular_function	L-aspartate transmembrane transporter activity
L	0015293	molecular_function	symporter activity
L	0015501	molecular_function	glutamate:sodium symporter activity
L	0016020	cellular_component	membrane
L	0022857	molecular_function	transmembrane transporter activity
L	0035725	biological_process	sodium ion transmembrane transport
L	0042802	molecular_function	identical protein binding
L	0046872	molecular_function	metal ion binding
L	0046942	biological_process	carboxylic acid transport
L	0070207	biological_process	protein homotrimerization
L	0070778	biological_process	L-aspartate transmembrane transport
L	0140009	biological_process	L-aspartate import across plasma membrane
L	1902476	biological_process	chloride transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00713
Number of Residues	16
Details	NA_DICARBOXYL_SYMP_1 Sodium:dicarboxylate symporter family signature 1. PfGDlFVrLLKMLVmP

Chain	Residue	Details
A	PRO45-PRO60

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	216
Details	TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:15483603

Chain	Residue	Details
A	VAL12-LEU30
B	VAL12-LEU30
C	VAL12-LEU30
D	VAL12-LEU30
E	VAL12-LEU30
F	VAL12-LEU30
G	VAL12-LEU30
H	VAL12-LEU30
I	VAL12-LEU30
J	VAL12-LEU30
K	VAL12-LEU30
L	VAL12-LEU30

---

site_id	SWS_FT_FI2
Number of Residues	864
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:15483603

Chain	Residue	Details
A	GLY31-THR41
A	ALA104-GLN121
A	GLU219-LYS230
A	CYS321-GLN337
A	PRO373-ALA391
B	GLY31-THR41
B	ALA104-GLN121
B	GLU219-LYS230
B	CYS321-GLN337
B	PRO373-ALA391
C	GLY31-THR41
C	ALA104-GLN121
C	GLU219-LYS230
C	CYS321-GLN337
C	PRO373-ALA391
D	GLY31-THR41
D	ALA104-GLN121
D	GLU219-LYS230
D	CYS321-GLN337
D	PRO373-ALA391
E	GLY31-THR41
E	ALA104-GLN121
E	GLU219-LYS230
E	CYS321-GLN337
E	PRO373-ALA391
F	GLY31-THR41
F	ALA104-GLN121
F	GLU219-LYS230
F	CYS321-GLN337
F	PRO373-ALA391
G	GLY31-THR41
G	ALA104-GLN121
G	GLU219-LYS230
G	CYS321-GLN337
G	PRO373-ALA391
H	GLY31-THR41
H	ALA104-GLN121
H	GLU219-LYS230
H	CYS321-GLN337
H	PRO373-ALA391
I	GLY31-THR41
I	ALA104-GLN121
I	GLU219-LYS230
I	CYS321-GLN337
I	PRO373-ALA391
J	GLY31-THR41
J	ALA104-GLN121
J	GLU219-LYS230
J	CYS321-GLN337
J	PRO373-ALA391
K	GLY31-THR41
K	ALA104-GLN121
K	GLU219-LYS230
K	CYS321-GLN337
K	PRO373-ALA391
L	GLY31-THR41
L	ALA104-GLN121
L	GLU219-LYS230
L	CYS321-GLN337
L	PRO373-ALA391

---

site_id	SWS_FT_FI3
Number of Residues	240
Details	TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:15483603

Chain	Residue	Details
A	TYR42-VAL62
B	TYR42-VAL62
C	TYR42-VAL62
D	TYR42-VAL62
E	TYR42-VAL62
F	TYR42-VAL62
G	TYR42-VAL62
H	TYR42-VAL62
I	TYR42-VAL62
J	TYR42-VAL62
K	TYR42-VAL62
L	TYR42-VAL62

---

site_id	SWS_FT_FI4
Number of Residues	804
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:15483603

Chain	Residue	Details
A	PHE63-ARG80
A	LEU161-LYS196
A	LYS252-SER260
A	LYS290-GLY297
B	PHE63-ARG80
B	LEU161-LYS196
B	LYS252-SER260
B	LYS290-GLY297
C	PHE63-ARG80
C	LEU161-LYS196
C	LYS252-SER260
C	LYS290-GLY297
D	PHE63-ARG80
D	LEU161-LYS196
D	LYS252-SER260
D	LYS290-GLY297
E	PHE63-ARG80
E	LEU161-LYS196
E	LYS252-SER260
E	LYS290-GLY297
F	PHE63-ARG80
F	LEU161-LYS196
F	LYS252-SER260
F	LYS290-GLY297
G	PHE63-ARG80
G	LEU161-LYS196
G	LYS252-SER260
G	LYS290-GLY297
H	PHE63-ARG80
H	LEU161-LYS196
H	LYS252-SER260
H	LYS290-GLY297
I	PHE63-ARG80
I	LEU161-LYS196
I	LYS252-SER260
I	LYS290-GLY297
J	PHE63-ARG80
J	LEU161-LYS196
J	LYS252-SER260
J	LYS290-GLY297
K	PHE63-ARG80
K	LEU161-LYS196
K	LYS252-SER260
K	LYS290-GLY297
L	PHE63-ARG80
L	LEU161-LYS196
L	LYS252-SER260
L	LYS290-GLY297

---

site_id	SWS_FT_FI5
Number of Residues	264
Details	TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:15483603

Chain	Residue	Details
A	VAL81-MET103
B	VAL81-MET103
C	VAL81-MET103
D	VAL81-MET103
E	VAL81-MET103
F	VAL81-MET103
G	VAL81-MET103
H	VAL81-MET103
I	VAL81-MET103
J	VAL81-MET103
K	VAL81-MET103
L	VAL81-MET103

---

site_id	SWS_FT_FI6
Number of Residues	456
Details	TRANSMEM: Discontinuously helical; Name=4 => ECO:0000269|PubMed:15483603

Chain	Residue	Details
A	PHE122-ILE160
B	PHE122-ILE160
C	PHE122-ILE160
D	PHE122-ILE160
E	PHE122-ILE160
F	PHE122-ILE160
G	PHE122-ILE160
H	PHE122-ILE160
I	PHE122-ILE160
J	PHE122-ILE160
K	PHE122-ILE160
L	PHE122-ILE160

---

site_id	SWS_FT_FI7
Number of Residues	252
Details	TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:15483603

Chain	Residue	Details
A	ILE197-ALA218
B	ILE197-ALA218
C	ILE197-ALA218
D	ILE197-ALA218
E	ILE197-ALA218
F	ILE197-ALA218
G	ILE197-ALA218
H	ILE197-ALA218
I	ILE197-ALA218
J	ILE197-ALA218
K	ILE197-ALA218
L	ILE197-ALA218

---

site_id	SWS_FT_FI8
Number of Residues	240
Details	TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:15483603

Chain	Residue	Details
A	VAL231-LEU251
B	VAL231-LEU251
C	VAL231-LEU251
D	VAL231-LEU251
E	VAL231-LEU251
F	VAL231-LEU251
G	VAL231-LEU251
H	VAL231-LEU251
I	VAL231-LEU251
J	VAL231-LEU251
K	VAL231-LEU251
L	VAL231-LEU251

---

site_id	SWS_FT_FI9
Number of Residues	744
Details	INTRAMEM: Discontinuously helical => ECO:0000269|PubMed:15483603

Chain	Residue	Details
A	PHE261-ALA289
A	GLN338-LEU372
B	PHE261-ALA289
B	GLN338-LEU372
C	PHE261-ALA289
C	GLN338-LEU372
D	PHE261-ALA289
D	GLN338-LEU372
E	PHE261-ALA289
E	GLN338-LEU372
F	PHE261-ALA289
F	GLN338-LEU372
G	PHE261-ALA289
G	GLN338-LEU372
H	PHE261-ALA289
H	GLN338-LEU372
I	PHE261-ALA289
I	GLN338-LEU372
J	PHE261-ALA289
J	GLN338-LEU372
K	PHE261-ALA289
K	GLN338-LEU372
L	PHE261-ALA289
L	GLN338-LEU372

---

site_id	SWS_FT_FI10
Number of Residues	264
Details	TRANSMEM: Discontinuously helical; Name=7 => ECO:0000269|PubMed:15483603

Chain	Residue	Details
A	ILE298-VAL320
B	ILE298-VAL320
C	ILE298-VAL320
D	ILE298-VAL320
E	ILE298-VAL320
F	ILE298-VAL320
G	ILE298-VAL320
H	ILE298-VAL320
I	ILE298-VAL320
J	ILE298-VAL320
K	ILE298-VAL320
L	ILE298-VAL320

---

site_id	SWS_FT_FI11
Number of Residues	240
Details	TRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:15483603

Chain	Residue	Details
A	ILE392-VAL412
B	ILE392-VAL412
C	ILE392-VAL412
D	ILE392-VAL412
E	ILE392-VAL412
F	ILE392-VAL412
G	ILE392-VAL412
H	ILE392-VAL412
I	ILE392-VAL412
J	ILE392-VAL412
K	ILE392-VAL412
L	ILE392-VAL412

---

site_id	SWS_FT_FI12
Number of Residues	48
Details	BINDING: BINDING => ECO:0000269|PubMed:17230192, ECO:0007744|PDB:2NWL, ECO:0007744|PDB:2NWX, ECO:0007744|PDB:3KBC

Chain	Residue	Details
G	ARG276
G	THR314
G	VAL355
G	ASP394
H	ARG276
H	THR314
H	VAL355
H	ASP394
I	ARG276
I	THR314
I	VAL355
I	ASP394
J	ARG276
J	THR314
J	VAL355
J	ASP394
K	ARG276
K	THR314
K	VAL355
K	ASP394
L	ARG276
L	THR314
L	VAL355
L	ASP394
A	ARG276
A	THR314
A	VAL355
A	ASP394
B	ARG276
B	THR314
B	VAL355
B	ASP394
C	ARG276
C	THR314
C	VAL355
C	ASP394
D	ARG276
D	THR314
D	VAL355
D	ASP394
E	ARG276
E	THR314
E	VAL355
E	ASP394
F	ARG276
F	THR314
F	VAL355
F	ASP394

---

site_id	SWS_FT_FI13
Number of Residues	60
Details	BINDING: BINDING => ECO:0000305|PubMed:17230192, ECO:0007744|PDB:2NWX

Chain	Residue	Details
E	ASP405
F	GLY306
F	THR308
F	THR352
F	ASN401
F	ASP405
G	GLY306
G	THR308
G	THR352
G	ASN401
G	ASP405
H	GLY306
H	THR308
H	THR352
H	ASN401
H	ASP405
I	GLY306
I	THR308
I	THR352
I	ASN401
I	ASP405
J	GLY306
J	THR308
J	THR352
J	ASN401
J	ASP405
K	GLY306
K	THR308
K	THR352
K	ASN401
K	ASP405
L	GLY306
L	THR308
L	THR352
L	ASN401
L	ASP405
A	GLY306
A	THR308
A	THR352
A	ASN401
A	ASP405
B	GLY306
B	THR308
B	THR352
B	ASN401
B	ASP405
C	GLY306
C	THR308
C	THR352
C	ASN401
C	ASP405
D	GLY306
D	THR308
D	THR352
D	ASN401
D	ASP405
E	GLY306
E	THR308
E	THR352
E	ASN401

---

site_id	SWS_FT_FI14
Number of Residues	12
Details	BINDING: BINDING => ECO:0000305|PubMed:17230192, ECO:0007744|PDB:2NWX, ECO:0007744|PDB:4X2S

Chain	Residue	Details
A	ASN310
B	ASN310
C	ASN310
D	ASN310
E	ASN310
F	ASN310
G	ASN310
H	ASN310
I	ASN310
J	ASN310
K	ASN310
L	ASN310

---