4OWZ
Structure of ECP/H15A mutant.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001530 | molecular_function | lipopolysaccharide binding |
| A | 0002227 | biological_process | innate immune response in mucosa |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0004540 | molecular_function | RNA nuclease activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006401 | biological_process | RNA catabolic process |
| A | 0006935 | biological_process | chemotaxis |
| A | 0019731 | biological_process | antibacterial humoral response |
| A | 0035578 | cellular_component | azurophil granule lumen |
| A | 0043152 | biological_process | induction of bacterial agglutination |
| A | 0045087 | biological_process | innate immune response |
| A | 0050829 | biological_process | defense response to Gram-negative bacterium |
| A | 0050830 | biological_process | defense response to Gram-positive bacterium |
| A | 0061844 | biological_process | antimicrobial humoral immune response mediated by antimicrobial peptide |
| B | 0001530 | molecular_function | lipopolysaccharide binding |
| B | 0002227 | biological_process | innate immune response in mucosa |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0004540 | molecular_function | RNA nuclease activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0006401 | biological_process | RNA catabolic process |
| B | 0006935 | biological_process | chemotaxis |
| B | 0019731 | biological_process | antibacterial humoral response |
| B | 0035578 | cellular_component | azurophil granule lumen |
| B | 0043152 | biological_process | induction of bacterial agglutination |
| B | 0045087 | biological_process | innate immune response |
| B | 0050829 | biological_process | defense response to Gram-negative bacterium |
| B | 0050830 | biological_process | defense response to Gram-positive bacterium |
| B | 0061844 | biological_process | antimicrobial humoral immune response mediated by antimicrobial peptide |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue CIT A 301 |
| Chain | Residue |
| A | THR46 |
| A | HOH514 |
| B | ARG121 |
| A | ASN50 |
| A | SER74 |
| A | ARG75 |
| A | ARG75 |
| A | PHE76 |
| A | TYR107 |
| A | HOH427 |
| A | HOH459 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | binding site for residue CIT A 302 |
| Chain | Residue |
| A | ARG34 |
| A | ARG34 |
| A | ARG36 |
| A | CYS37 |
| A | CYS37 |
| A | LYS38 |
| A | LYS38 |
| A | ASN39 |
| A | ASN39 |
| A | FE303 |
| A | FE303 |
| A | HOH401 |
| A | HOH401 |
| A | HOH403 |
| A | HOH403 |
| A | HOH410 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue FE A 303 |
| Chain | Residue |
| A | CIT302 |
| A | CIT302 |
| A | HOH401 |
| A | HOH403 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | binding site for residue CIT B 301 |
| Chain | Residue |
| A | ARG61 |
| A | ARG66 |
| B | THR46 |
| B | ASN50 |
| B | VAL54 |
| B | SER74 |
| B | ARG75 |
| B | PHE76 |
| B | VAL78 |
| B | TYR107 |
| B | HOH405 |
| B | HOH423 |
| B | HOH532 |
| site_id | AC5 |
| Number of Residues | 16 |
| Details | binding site for residue CIT B 302 |
| Chain | Residue |
| B | ARG34 |
| B | ARG34 |
| B | CYS37 |
| B | LYS38 |
| B | LYS38 |
| B | ASN39 |
| B | ASN39 |
| B | FE303 |
| B | FE303 |
| B | HOH401 |
| B | HOH401 |
| B | HOH404 |
| B | HOH408 |
| B | HOH418 |
| B | HOH418 |
| B | HOH419 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue FE B 303 |
| Chain | Residue |
| B | CIT302 |
| B | CIT302 |
| B | HOH404 |
| B | HOH408 |
| B | HOH418 |
Functional Information from PROSITE/UniProt
| site_id | PS00127 |
| Number of Residues | 7 |
| Details | RNASE_PANCREATIC Pancreatic ribonuclease family signature. CKnqNTF |
| Chain | Residue | Details |
| A | CYS37-PHE43 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 88 |
| Details | Region: {"description":"Required for nearly all of the bactericidal activity; partially involved in LPS-binding and bacterial membrane depolarization"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Site: {"description":"May be involved in LPS-binding"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Site: {"description":"May be involved in LPS- and LTA-binding"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"PubMed","id":"18694936","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
