4OWY
Crystal Structure of Ahp1 from Saccharomyces cerevisiae. Investigating the electron transfers.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004601 | molecular_function | peroxidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005777 | cellular_component | peroxisome |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0008379 | molecular_function | thioredoxin peroxidase activity |
| A | 0010038 | biological_process | response to metal ion |
| A | 0016209 | molecular_function | antioxidant activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0034599 | biological_process | cellular response to oxidative stress |
| A | 0042744 | biological_process | hydrogen peroxide catabolic process |
| A | 0045454 | biological_process | cell redox homeostasis |
| A | 0050821 | biological_process | protein stabilization |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| A | 0140824 | molecular_function | thioredoxin-dependent peroxiredoxin activity |
| B | 0004601 | molecular_function | peroxidase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005777 | cellular_component | peroxisome |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0008379 | molecular_function | thioredoxin peroxidase activity |
| B | 0010038 | biological_process | response to metal ion |
| B | 0016209 | molecular_function | antioxidant activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0034599 | biological_process | cellular response to oxidative stress |
| B | 0042744 | biological_process | hydrogen peroxide catabolic process |
| B | 0045454 | biological_process | cell redox homeostasis |
| B | 0050821 | biological_process | protein stabilization |
| B | 0098869 | biological_process | cellular oxidant detoxification |
| B | 0140824 | molecular_function | thioredoxin-dependent peroxiredoxin activity |
| C | 0004601 | molecular_function | peroxidase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005777 | cellular_component | peroxisome |
| C | 0005829 | cellular_component | cytosol |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0008379 | molecular_function | thioredoxin peroxidase activity |
| C | 0010038 | biological_process | response to metal ion |
| C | 0016209 | molecular_function | antioxidant activity |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0034599 | biological_process | cellular response to oxidative stress |
| C | 0042744 | biological_process | hydrogen peroxide catabolic process |
| C | 0045454 | biological_process | cell redox homeostasis |
| C | 0050821 | biological_process | protein stabilization |
| C | 0098869 | biological_process | cellular oxidant detoxification |
| C | 0140824 | molecular_function | thioredoxin-dependent peroxiredoxin activity |
| D | 0004601 | molecular_function | peroxidase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005739 | cellular_component | mitochondrion |
| D | 0005777 | cellular_component | peroxisome |
| D | 0005829 | cellular_component | cytosol |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0008379 | molecular_function | thioredoxin peroxidase activity |
| D | 0010038 | biological_process | response to metal ion |
| D | 0016209 | molecular_function | antioxidant activity |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0034599 | biological_process | cellular response to oxidative stress |
| D | 0042744 | biological_process | hydrogen peroxide catabolic process |
| D | 0045454 | biological_process | cell redox homeostasis |
| D | 0050821 | biological_process | protein stabilization |
| D | 0098869 | biological_process | cellular oxidant detoxification |
| D | 0140824 | molecular_function | thioredoxin-dependent peroxiredoxin activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue PEG A 201 |
| Chain | Residue |
| A | MET33 |
| C | MET33 |
| C | GLN35 |
| C | HOH324 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue PEG B 201 |
| Chain | Residue |
| B | ASP13 |
| B | GLU38 |
| B | HOH301 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | binding site for residue PEG B 202 |
| Chain | Residue |
| B | SER125 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue ACY B 203 |
| Chain | Residue |
| B | MET33 |
| B | PHE95 |
| B | LYS32 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue PEG B 204 |
| Chain | Residue |
| B | TYR18 |
| B | ALA20 |
| B | GLN35 |
| B | THR109 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue ACY C 201 |
| Chain | Residue |
| C | ASP75 |
| C | HIS111 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue ACY D 201 |
| Chain | Residue |
| D | TYR18 |
| D | VAL37 |
| D | GLU45 |
| D | LYS113 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue ACY D 202 |
| Chain | Residue |
| D | GLY105 |
| D | VAL106 |
| D | LYS107 |
| D | ASP108 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue TBU D 203 |
| Chain | Residue |
| D | ASP13 |
| D | GLU38 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Cysteine sulfenic acid (-SOH) intermediate","evidences":[{"source":"PubMed","id":"22474296","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"Cysteine persulfide","evidences":[{"source":"PubMed","id":"36102610","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in URM1)","evidences":[{"source":"PubMed","id":"32004955","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36102610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21209336","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in URM1); alternate","evidences":[{"source":"PubMed","id":"32004955","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36102610","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in URM1); alternate","evidences":[{"source":"PubMed","id":"36102610","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 12 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in URM1)","evidences":[{"source":"PubMed","id":"36102610","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 334 |
| Details | Domain: {"description":"Thioredoxin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00691","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
