4OW8

Crystal structure of kinase domain of PknA from Mtb

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue GOL A 301

Chain	Residue
A	ARG59
A	ALA62
A	ARG63
A	ALA66
A	VAL76
A	TYR79

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site_id	AC2
Number of Residues	6
Details	binding site for residue SO4 A 302

Chain	Residue
A	ARG116
A	HIS117
A	HIS117
A	SER114
A	SER114
A	ARG116

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Functional Information from PROSITE/UniProt

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LvHrDVKpgNILI

Chain	Residue	Details
A	LEU137-ILE149

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027

Chain	Residue	Details
A	ASP141

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	ILE19
A	LYS42

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site_id	SWS_FT_FI3
Number of Residues	10
Details	MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:25586004

Chain	Residue	Details
A	THR8
A	THR252
A	THR21
A	THR64
A	THR65
A	THR90
A	THR125
A	THR152
A	THR158
A	THR224

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site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|PubMed:25586004

Chain	Residue	Details
A	SER10
A	SER46
A	SER75
A	SER105
A	SER198
A	SER263

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site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:25665034

Chain	Residue	Details
A	THR172
A	THR174
A	THR180

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