4OV6

Crystal structure of PCSK9(53-451) with Adnectin

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0004252	molecular_function	serine-type endopeptidase activity
B	0006508	biological_process	proteolysis
B	0008236	molecular_function	serine-type peptidase activity
E	0004252	molecular_function	serine-type endopeptidase activity
E	0006508	biological_process	proteolysis
E	0008236	molecular_function	serine-type peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 201

Chain	Residue
A	TRP72
A	PHE150
B	LYS258
F	HIS80

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site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO B 501

Chain	Residue
B	PHE318
B	ARG319

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site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO B 502

Chain	Residue
B	PHE379

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site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PG4 B 503

Chain	Residue
E	GLN413
B	GLN413
B	ILE416

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site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PG4 D 201

Chain	Residue
D	LEU108
D	LYS125
D	MET126
D	HOH308

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Functional Information from PROSITE/UniProt

site_id	PS00687
Number of Residues	8
Details	ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. GETGGNSP

Chain	Residue	Details
F	GLY37-PRO44

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	144
Details	Domain: {"description":"Inhibitor I9","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	6
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PROSITE-ProRule","id":"PRU01240","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Site: {"description":"Cleavage; by furin and PCSK5","evidences":[{"source":"PubMed","id":"16912035","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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