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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

4OV2

Crystal structure of C-terminally truncated Neuronal Calcium Sensor (NCS-1) from Rattus norvegicus

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0005245molecular_functionvoltage-gated calcium channel activity
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0008048molecular_functioncalcium sensitive guanylate cyclase activator activity
A0008427molecular_functioncalcium-dependent protein kinase inhibitor activity
A0009966biological_processregulation of signal transduction
A0010975biological_processregulation of neuron projection development
A0014069cellular_componentpostsynaptic density
A0016020cellular_componentmembrane
A0019901molecular_functionprotein kinase binding
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0031045cellular_componentdense core granule
A0044305cellular_componentcalyx of Held
A0045921biological_processpositive regulation of exocytosis
A0046872molecular_functionmetal ion binding
A0048471cellular_componentperinuclear region of cytoplasm
A0050850biological_processpositive regulation of calcium-mediated signaling
A0070588biological_processcalcium ion transmembrane transport
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0099509biological_processregulation of presynaptic cytosolic calcium ion concentration
A0099523cellular_componentpresynaptic cytosol
A0099524cellular_componentpostsynaptic cytosol
A2000300biological_processregulation of synaptic vesicle exocytosis
B0000287molecular_functionmagnesium ion binding
B0005245molecular_functionvoltage-gated calcium channel activity
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0008048molecular_functioncalcium sensitive guanylate cyclase activator activity
B0008427molecular_functioncalcium-dependent protein kinase inhibitor activity
B0009966biological_processregulation of signal transduction
B0010975biological_processregulation of neuron projection development
B0014069cellular_componentpostsynaptic density
B0016020cellular_componentmembrane
B0019901molecular_functionprotein kinase binding
B0030424cellular_componentaxon
B0030425cellular_componentdendrite
B0031045cellular_componentdense core granule
B0044305cellular_componentcalyx of Held
B0045921biological_processpositive regulation of exocytosis
B0046872molecular_functionmetal ion binding
B0048471cellular_componentperinuclear region of cytoplasm
B0050850biological_processpositive regulation of calcium-mediated signaling
B0070588biological_processcalcium ion transmembrane transport
B0098794cellular_componentpostsynapse
B0098978cellular_componentglutamatergic synapse
B0099509biological_processregulation of presynaptic cytosolic calcium ion concentration
B0099523cellular_componentpresynaptic cytosol
B0099524cellular_componentpostsynaptic cytosol
B2000300biological_processregulation of synaptic vesicle exocytosis
C0000287molecular_functionmagnesium ion binding
C0005245molecular_functionvoltage-gated calcium channel activity
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005794cellular_componentGolgi apparatus
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0008048molecular_functioncalcium sensitive guanylate cyclase activator activity
C0008427molecular_functioncalcium-dependent protein kinase inhibitor activity
C0009966biological_processregulation of signal transduction
C0010975biological_processregulation of neuron projection development
C0014069cellular_componentpostsynaptic density
C0016020cellular_componentmembrane
C0019901molecular_functionprotein kinase binding
C0030424cellular_componentaxon
C0030425cellular_componentdendrite
C0031045cellular_componentdense core granule
C0044305cellular_componentcalyx of Held
C0045921biological_processpositive regulation of exocytosis
C0046872molecular_functionmetal ion binding
C0048471cellular_componentperinuclear region of cytoplasm
C0050850biological_processpositive regulation of calcium-mediated signaling
C0070588biological_processcalcium ion transmembrane transport
C0098794cellular_componentpostsynapse
C0098978cellular_componentglutamatergic synapse
C0099509biological_processregulation of presynaptic cytosolic calcium ion concentration
C0099523cellular_componentpresynaptic cytosol
C0099524cellular_componentpostsynaptic cytosol
C2000300biological_processregulation of synaptic vesicle exocytosis
D0000287molecular_functionmagnesium ion binding
D0005245molecular_functionvoltage-gated calcium channel activity
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005794cellular_componentGolgi apparatus
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0008048molecular_functioncalcium sensitive guanylate cyclase activator activity
D0008427molecular_functioncalcium-dependent protein kinase inhibitor activity
D0009966biological_processregulation of signal transduction
D0010975biological_processregulation of neuron projection development
D0014069cellular_componentpostsynaptic density
D0016020cellular_componentmembrane
D0019901molecular_functionprotein kinase binding
D0030424cellular_componentaxon
D0030425cellular_componentdendrite
D0031045cellular_componentdense core granule
D0044305cellular_componentcalyx of Held
D0045921biological_processpositive regulation of exocytosis
D0046872molecular_functionmetal ion binding
D0048471cellular_componentperinuclear region of cytoplasm
D0050850biological_processpositive regulation of calcium-mediated signaling
D0070588biological_processcalcium ion transmembrane transport
D0098794cellular_componentpostsynapse
D0098978cellular_componentglutamatergic synapse
D0099509biological_processregulation of presynaptic cytosolic calcium ion concentration
D0099523cellular_componentpresynaptic cytosol
D0099524cellular_componentpostsynaptic cytosol
D2000300biological_processregulation of synaptic vesicle exocytosis
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA A 201
ChainResidue
AASP73
AASN75
AASP77
AARG79
AGLU84
site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA A 202
ChainResidue
AGLU120
AASP109
AASP111
AASP113
ATYR115
site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA A 203
ChainResidue
AASP157
AASN159
AASP161
ALYS163
AGLU168
site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA B 201
ChainResidue
BASP73
BASN75
BASP77
BARG79
BGLU84
site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA B 202
ChainResidue
BASP109
BASP111
BASP113
BTYR115
BGLU120
BHOH301
site_idAC6
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA B 203
ChainResidue
BASP157
BASN159
BASP161
BLYS163
BGLU168
DHOH308
site_idAC7
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA C 201
ChainResidue
CASP73
CASN75
CASP77
CARG79
CGLU81
CGLU84
site_idAC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA C 202
ChainResidue
CASP109
CASP111
CASP113
CTYR115
CGLU120
site_idAC9
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA C 203
ChainResidue
CASP157
CASN159
CASP161
CLYS163
CGLU168
site_idBC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA D 201
ChainResidue
DASP73
DASN75
DASP77
DARG79
DGLU81
DGLU84
site_idBC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA D 202
ChainResidue
DASP109
DASP111
DASP113
DTYR115
DGLU120
site_idBC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA D 203
ChainResidue
DASP157
DASN159
DASP161
DLYS163
DGLU168
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DENKDGRIEfsEF
ChainResidueDetails
AASP73-PHE85
AASP109-MET121
AASP157-PHE169
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues70
DetailsDomain: {"description":"EF-hand 1","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues140
DetailsDomain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues140
DetailsDomain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues22
DetailsRegion: {"description":"Ancestral calcium site 1"}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues20
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25979333","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4OV2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YRU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AEQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AER","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"25979333","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4YRU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AEQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AER","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues20
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25979333","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4OV2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YRU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AEQ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues20
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25979333","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4OV2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YRU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AEQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AER","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AFP","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

245663

PDB entries from 2025-12-03

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