4OUC

Structure of human haspin in complex with histone H3 substrate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 801

Chain	Residue
A	GLU554
A	PHE556
A	SER684
A	HOH1107
A	HOH1108

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 802

Chain	Residue
A	HOH1133
A	ILE610
A	MET615
A	LEU657
A	HOH1125

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 803

Chain	Residue
A	THR553
A	GLY555
A	GLN631
A	SER635
A	GLN682
A	HOH1045
A	HOH1143

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 804

Chain	Residue
A	LEU520
A	PHE593

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 805

Chain	Residue
A	GLU728
A	TYR739
A	HOH1016
A	HOH1167

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 806

Chain	Residue
A	PHE475
A	GLY567
A	SER568
A	HOH923
A	HOH931

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 807

Chain	Residue
A	LYS761
A	CYS762
A	LYS771
A	HOH1177
A	HOH1293

---

site_id	AC8
Number of Residues	18
Details	BINDING SITE FOR RESIDUE 5ID A 808

Chain	Residue
A	ILE490
A	GLY491
A	GLU492
A	VAL498
A	ALA509
A	PHE605
A	GLU606
A	PHE607
A	GLY608
A	GLY609
A	ASP611
A	GLY653
A	LEU656
A	ILE686
A	IOD809
A	HOH912
A	HOH951
A	HOH1130

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE IOD A 809

Chain	Residue
A	LYS511
A	PHE605
A	ASP687
A	5ID808

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	22
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGVFGEVFqTiadhtp............VAIK

Chain	Residue	Details
A	ILE490-LYS511

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Citrulline; alternate => ECO:0000269|PubMed:16567635

Chain	Residue	Details
B	ARG2

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088

Chain	Residue	Details
B	THR3
A	LYS511

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:17194708

Chain	Residue	Details
B	LYS4
A	ASP649

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: 5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594

Chain	Residue	Details
B	GLN5

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790

Chain	Residue	Details
B	THR6

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250|UniProtKB:P84228

Chain	Residue	Details
B	ARG8

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:11242053, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:17194708

Chain	Residue	Details
B	LYS9

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088

Chain	Residue	Details
B	SER10

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by PKC => ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:22901803

Chain	Residue	Details
B	THR11

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