4OTP

Crystal structure of the catalytic domain of the human RioK1 atypical protein kinase in complex with ADP/Mg2+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005524	molecular_function	ATP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ADP A 501

Chain	Residue
A	ILE186
A	ASN329
A	ILE340
A	PHD341
A	MG502
A	HOH602
A	HOH603
A	HOH604
A	SER187
A	VAL194
A	LYS208
A	PRO265
A	MSE277
A	SER278
A	ILE280
A	LEU289

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 502

Chain	Residue
A	ASN329
A	PHD341
A	ADP501
A	HOH602
A	HOH603
A	HOH604

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Functional Information from PROSITE/UniProt

site_id	PS01245
Number of Residues	12
Details	RIO1 RIO1/ZK632.3/MJ0444 family signature. LVHADLSEFNmL

Chain	Residue	Details
A	LEU320-LEU331

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"22072790","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24948609","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"4-aspartylphosphate intermediate","evidences":[{"source":"PubMed","id":"24948609","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4OTP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24948609","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4OTP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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