Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4OSX

STRUCTURE of UNCLEAVED GLYCINE-BOUND HUMAN L-ASPARAGINASE PROTEIN

Replaces:  4HLO
Functional Information from GO Data
ChainGOidnamespacecontents
A0001917cellular_componentphotoreceptor inner segment
A0003948molecular_functionN4-(beta-N-acetylglucosaminyl)-L-asparaginase activity
A0004067molecular_functionasparaginase activity
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006508biological_processproteolysis
A0008233molecular_functionpeptidase activity
A0008798molecular_functionbeta-aspartyl-peptidase activity
A0016787molecular_functionhydrolase activity
A0033345biological_processasparagine catabolic process via L-aspartate
B0001917cellular_componentphotoreceptor inner segment
B0003948molecular_functionN4-(beta-N-acetylglucosaminyl)-L-asparaginase activity
B0004067molecular_functionasparaginase activity
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006508biological_processproteolysis
B0008233molecular_functionpeptidase activity
B0008798molecular_functionbeta-aspartyl-peptidase activity
B0016787molecular_functionhydrolase activity
B0033345biological_processasparagine catabolic process via L-aspartate
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE NA A 401
ChainResidue
ALEU55
AGLU56
AASP58
APHE61
AALA63
ACYS65

site_idAC2
Number of Residues9
DetailsBINDING SITE FOR RESIDUE GLY A 402
ChainResidue
AASP199
ASER200
AGLY220
AGLY222
AGLY403
AHOH516
ATHR168
ATHR186
AARG196

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GLY A 403
ChainResidue
AGLY10
ALEU166
AGLY167
ATHR168
ATHR219
AGLY220
AGLY402

site_idAC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GLY A 404
ChainResidue
ASER88
AALA89
AVAL108
AMET109
ATHR112
AHIS114
BLYS227

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE NA B 401
ChainResidue
BLEU55
BGLU56
BASP58
BPHE61
BALA63
BCYS65

site_idAC6
Number of Residues8
DetailsBINDING SITE FOR RESIDUE GLY B 402
ChainResidue
ALYS227
BSER88
BALA89
BVAL108
BMET109
BTHR112
BHIS114
BCYS115

site_idAC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GLY B 403
ChainResidue
BARG196
BASP199
BGLY220
BGLY222
BHOH568

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Nucleophile => ECO:0000269|PubMed:19839645, ECO:0000269|PubMed:22861376
ChainResidueDetails
ATHR168
BTHR168

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING:
ChainResidueDetails
AARG196
ATHR219
BARG196
BTHR219

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N-acetylmethionine => ECO:0007744|PubMed:19413330
ChainResidueDetails
AMET1
BMET1

226707

PDB entries from 2024-10-30

PDB statisticsPDBj update infoContact PDBjnumon