4ORI
Rat dihydroorotate dehydrogenase bound with DSM338 (N-[3,5-difluoro-4-(trifluoromethyl)phenyl]-5-methyl-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004151 | molecular_function | dihydroorotase activity |
A | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0005739 | cellular_component | mitochondrion |
A | 0005743 | cellular_component | mitochondrial inner membrane |
A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
A | 0006225 | biological_process | UDP biosynthetic process |
A | 0007565 | biological_process | female pregnancy |
A | 0007595 | biological_process | lactation |
A | 0009220 | biological_process | pyrimidine ribonucleotide biosynthetic process |
A | 0009410 | biological_process | response to xenobiotic stimulus |
A | 0010181 | molecular_function | FMN binding |
A | 0014070 | biological_process | response to organic cyclic compound |
A | 0016020 | cellular_component | membrane |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
A | 0031000 | biological_process | response to caffeine |
A | 0042594 | biological_process | response to starvation |
A | 0043025 | cellular_component | neuronal cell body |
A | 0043065 | biological_process | positive regulation of apoptotic process |
A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
A | 0048038 | molecular_function | quinone binding |
A | 0048039 | molecular_function | ubiquinone binding |
A | 0090140 | biological_process | regulation of mitochondrial fission |
A | 0106430 | molecular_function | dihydroorotate dehydrogenase (quinone) activity |
A | 1903576 | biological_process | response to L-arginine |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 25 |
Details | BINDING SITE FOR RESIDUE FMN A 500 |
Chain | Residue |
A | ALA95 |
A | LYS255 |
A | THR283 |
A | ASN284 |
A | THR285 |
A | SER305 |
A | GLY306 |
A | VAL333 |
A | GLY334 |
A | GLY335 |
A | LEU355 |
A | ALA96 |
A | TYR356 |
A | THR357 |
A | ORO501 |
A | HOH601 |
A | HOH602 |
A | HOH710 |
A | GLY97 |
A | LYS100 |
A | SER120 |
A | ASN145 |
A | TYR147 |
A | ASN181 |
A | ASN212 |
site_id | AC2 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE ORO A 501 |
Chain | Residue |
A | ASN145 |
A | TYR147 |
A | GLY148 |
A | PHE149 |
A | ASN212 |
A | SER215 |
A | ASN217 |
A | ASN284 |
A | THR285 |
A | FMN500 |
A | HOH710 |
site_id | AC3 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE 2V6 A 502 |
Chain | Residue |
A | GLN47 |
A | PRO52 |
A | ALA55 |
A | ALA59 |
A | VAL134 |
A | ARG136 |
A | TYR356 |
A | ILE360 |
A | PRO364 |
A | HOH605 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Nucleophile => ECO:0000250 |
Chain | Residue | Details |
A | SER215 |
site_id | SWS_FT_FI2 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15044733 |
Chain | Residue | Details |
A | ALA96 | |
A | SER120 | |
A | ASN181 | |
A | LYS255 | |
A | THR283 | |
A | GLY306 | |
A | GLY335 | |
A | TYR356 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | BINDING: |
Chain | Residue | Details |
A | LYS100 | |
A | ASN145 | |
A | ASN212 | |
A | ASN284 |