4OQG
Crystal structure of TEM-1 beta-lactamase in complex with boron-based inhibitor EC25
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008800 | molecular_function | beta-lactamase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0017001 | biological_process | antibiotic catabolic process |
| A | 0030655 | biological_process | beta-lactam antibiotic catabolic process |
| A | 0046677 | biological_process | response to antibiotic |
| B | 0008800 | molecular_function | beta-lactamase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0017001 | biological_process | antibiotic catabolic process |
| B | 0030655 | biological_process | beta-lactam antibiotic catabolic process |
| B | 0046677 | biological_process | response to antibiotic |
| C | 0008800 | molecular_function | beta-lactamase activity |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0017001 | biological_process | antibiotic catabolic process |
| C | 0030655 | biological_process | beta-lactam antibiotic catabolic process |
| C | 0046677 | biological_process | response to antibiotic |
| D | 0008800 | molecular_function | beta-lactamase activity |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0017001 | biological_process | antibiotic catabolic process |
| D | 0030655 | biological_process | beta-lactam antibiotic catabolic process |
| D | 0046677 | biological_process | response to antibiotic |
| E | 0008800 | molecular_function | beta-lactamase activity |
| E | 0016787 | molecular_function | hydrolase activity |
| E | 0017001 | biological_process | antibiotic catabolic process |
| E | 0030655 | biological_process | beta-lactam antibiotic catabolic process |
| E | 0046677 | biological_process | response to antibiotic |
| F | 0008800 | molecular_function | beta-lactamase activity |
| F | 0016787 | molecular_function | hydrolase activity |
| F | 0017001 | biological_process | antibiotic catabolic process |
| F | 0030655 | biological_process | beta-lactam antibiotic catabolic process |
| F | 0046677 | biological_process | response to antibiotic |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 2UL A 301 |
| Chain | Residue |
| A | MET69 |
| A | GLY236 |
| A | ALA237 |
| A | ARG244 |
| A | SER70 |
| A | GLU104 |
| A | SER130 |
| A | ASN132 |
| A | GLU166 |
| A | ASN170 |
| A | LYS234 |
| A | SER235 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE 2UL B 301 |
| Chain | Residue |
| A | GLU197 |
| B | MET69 |
| B | SER70 |
| B | GLU104 |
| B | TYR105 |
| B | SER130 |
| B | ASN132 |
| B | GLU166 |
| B | PRO167 |
| B | LEU169 |
| B | ASN170 |
| B | LYS234 |
| B | SER235 |
| B | GLY236 |
| B | ALA237 |
| B | GLY238 |
| B | ARG244 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN B 302 |
| Chain | Residue |
| B | HIS96 |
| B | HIS96 |
| B | HOH407 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 2UL C 301 |
| Chain | Residue |
| C | MET69 |
| C | SER70 |
| C | GLU104 |
| C | SER130 |
| C | ASN132 |
| C | GLU166 |
| C | ASN170 |
| C | LYS234 |
| C | SER235 |
| C | GLY236 |
| C | ALA237 |
| C | GLY238 |
| C | ARG244 |
| site_id | AC5 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 2UL D 301 |
| Chain | Residue |
| D | MET69 |
| D | SER70 |
| D | GLU104 |
| D | TYR105 |
| D | SER130 |
| D | ASN132 |
| D | GLU166 |
| D | ASN170 |
| D | SER235 |
| D | GLY236 |
| D | ALA237 |
| D | GLU240 |
| D | ARG244 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 2UL F 301 |
| Chain | Residue |
| F | MET69 |
| F | SER70 |
| F | SER130 |
| F | ASN132 |
| F | GLU166 |
| F | ASN170 |
| F | VAL216 |
| F | LYS234 |
| F | SER235 |
| F | GLY236 |
| F | ALA237 |
| F | ARG244 |
Functional Information from PROSITE/UniProt
| site_id | PS00146 |
| Number of Residues | 16 |
| Details | BETA_LACTAMASE_A Beta-lactamase class-A active site. FpMMSTfKvllCGAVL |
| Chain | Residue | Details |
| A | PHE66-LEU81 |
