4OL9
Crystal Structure of putative 2-dehydropantoate 2-reductase PanE from Mycobacterium tuberculosis complexed with NADP and oxamate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0008677 | molecular_function | 2-dehydropantoate 2-reductase activity |
| A | 0015940 | biological_process | pantothenate biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 35 |
| Details | BINDING SITE FOR RESIDUE NAP A 301 |
| Chain | Residue |
| A | GLY9 |
| A | ALA72 |
| A | VAL73 |
| A | LYS74 |
| A | GLN77 |
| A | ALA80 |
| A | TRP84 |
| A | LEU98 |
| A | GLN99 |
| A | ASN100 |
| A | VAL122 |
| A | PRO10 |
| A | CYS124 |
| A | ALA126 |
| A | SER246 |
| A | ARG255 |
| A | GLU258 |
| A | OXM302 |
| A | ACT303 |
| A | HOH409 |
| A | HOH444 |
| A | HOH503 |
| A | GLY11 |
| A | HOH516 |
| A | HOH579 |
| A | HOH580 |
| A | HOH619 |
| A | HOH620 |
| A | HOH659 |
| A | ALA12 |
| A | VAL13 |
| A | CYS31 |
| A | GLY32 |
| A | HIS33 |
| A | THR34 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE OXM A 302 |
| Chain | Residue |
| A | ASN100 |
| A | CYS124 |
| A | LYS177 |
| A | ASN181 |
| A | THR245 |
| A | SER246 |
| A | ARG262 |
| A | NAP301 |
| A | HOH580 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT A 303 |
| Chain | Residue |
| A | PRO10 |
| A | THR34 |
| A | VAL55 |
| A | NAP301 |
| A | HOH620 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 304 |
| Chain | Residue |
| A | ARG158 |
| A | ARG198 |
| A | GLN241 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 305 |
| Chain | Residue |
| A | ARG199 |
| A | ASP200 |
| A | ASP201 |
| A | HOH590 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P0A9J4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JAN-2014","submissionDatabase":"PDB data bank","title":"Crystal structure of putative 2-dehydropantoate 2-reductase PanE from Mycobacterium tuberculosis complexed with NADP and oxamate.","authoringGroup":["Seattle Structural Genomics Center for Infectious Disease (SSGCID)"],"authors":["Dranow D.M.","Wernimont A.K.","Abendroth A.","Pierce P.G.","Bullen J.","Edwards T.E.","Lorimer D."]}},{"source":"PDB","id":"4OL9","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P0A9J4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
