4OKH
Crystal structure of calpain-3 penta-EF-hand domain
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 901 |
| Chain | Residue |
| A | ALA662 |
| A | ASP665 |
| A | GLU667 |
| A | GLU672 |
| A | HOH1014 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 902 |
| Chain | Residue |
| A | GLU716 |
| A | HOH1011 |
| A | ASP705 |
| A | ASP707 |
| A | SER709 |
| A | LYS711 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 903 |
| Chain | Residue |
| A | ASP735 |
| A | ASP737 |
| A | SER739 |
| A | THR741 |
| A | HOH1012 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 904 |
| Chain | Residue |
| A | ASP800 |
| A | ASP802 |
| A | ASP804 |
| A | ILE806 |
| A | HOH1005 |
| A | HOH1008 |
| site_id | AC5 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE PEU A 905 |
| Chain | Residue |
| A | ARG794 |
| A | ALA795 |
| A | ALA798 |
| A | PHE799 |
| A | ASN810 |
| A | LEU812 |
| A | GLU813 |
| A | GLN816 |
| A | TYR820 |
| B | ASN759 |
| B | ASN760 |
| B | GLN761 |
| B | GLN761 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 901 |
| Chain | Residue |
| B | ALA662 |
| B | ASP665 |
| B | GLU667 |
| B | GLU672 |
| B | HOH1010 |
| B | HOH1011 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 902 |
| Chain | Residue |
| B | ASP705 |
| B | ASP707 |
| B | SER709 |
| B | LYS711 |
| B | GLU716 |
| B | HOH1013 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 903 |
| Chain | Residue |
| B | ASP735 |
| B | ASP737 |
| B | SER739 |
| B | THR741 |
| B | HOH1012 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 904 |
| Chain | Residue |
| B | ASP800 |
| B | ASP802 |
| B | ASP804 |
| B | ILE806 |
| B | HOH1007 |
| B | HOH1009 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PEU B 905 |
| Chain | Residue |
| B | PHE799 |
| B | ILE807 |
| B | LYS808 |
| B | LEU809 |
| B | LEU817 |
| B | TYR820 |
| B | HOH1007 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA C 901 |
| Chain | Residue |
| C | ASP705 |
| C | ASP707 |
| C | SER709 |
| C | LYS711 |
| C | GLU716 |
| C | HOH1007 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA C 902 |
| Chain | Residue |
| C | ASP735 |
| C | ASP737 |
| C | SER739 |
| C | THR741 |
| C | HOH1002 |
| C | HOH1004 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA C 903 |
| Chain | Residue |
| C | ASP800 |
| C | ASP802 |
| C | ASP804 |
| C | ILE806 |
| C | HOH1006 |
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DTDGSGKLNlqEF |
| Chain | Residue | Details |
| A | ASP705-PHE717 | |
| A | ASP735-MET747 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 99 |
| Details | Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 105 |
| Details | Domain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 68 |
| Details | Domain: {"description":"EF-hand 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 23 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24846670","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4OKH","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 27 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24846670","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4OKH","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
