4OKH

Crystal structure of calpain-3 penta-EF-hand domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding
B	0005509	molecular_function	calcium ion binding
C	0005509	molecular_function	calcium ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 901

Chain	Residue
A	ALA662
A	ASP665
A	GLU667
A	GLU672
A	HOH1014

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 902

Chain	Residue
A	GLU716
A	HOH1011
A	ASP705
A	ASP707
A	SER709
A	LYS711

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 903

Chain	Residue
A	ASP735
A	ASP737
A	SER739
A	THR741
A	HOH1012

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 904

Chain	Residue
A	ASP800
A	ASP802
A	ASP804
A	ILE806
A	HOH1005
A	HOH1008

---

site_id	AC5
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PEU A 905

Chain	Residue
A	ARG794
A	ALA795
A	ALA798
A	PHE799
A	ASN810
A	LEU812
A	GLU813
A	GLN816
A	TYR820
B	ASN759
B	ASN760
B	GLN761
B	GLN761

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 901

Chain	Residue
B	ALA662
B	ASP665
B	GLU667
B	GLU672
B	HOH1010
B	HOH1011

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 902

Chain	Residue
B	ASP705
B	ASP707
B	SER709
B	LYS711
B	GLU716
B	HOH1013

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 903

Chain	Residue
B	ASP735
B	ASP737
B	SER739
B	THR741
B	HOH1012

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 904

Chain	Residue
B	ASP800
B	ASP802
B	ASP804
B	ILE806
B	HOH1007
B	HOH1009

---

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PEU B 905

Chain	Residue
B	PHE799
B	ILE807
B	LYS808
B	LEU809
B	LEU817
B	TYR820
B	HOH1007

---

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 901

Chain	Residue
C	ASP705
C	ASP707
C	SER709
C	LYS711
C	GLU716
C	HOH1007

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 902

Chain	Residue
C	ASP735
C	ASP737
C	SER739
C	THR741
C	HOH1002
C	HOH1004

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA C 903

Chain	Residue
C	ASP800
C	ASP802
C	ASP804
C	ILE806
C	HOH1006

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DTDGSGKLNlqEF

Chain	Residue	Details
A	ASP705-PHE717
A	ASP735-MET747

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269|PubMed:24846670, ECO:0007744|PDB:4OKH

Chain	Residue	Details
A	ALA662
B	ASP665
B	GLU667
B	GLU672
B	ASP800
B	ASP802
B	ASP804
B	ILE806
C	ALA662
C	ASP665
C	GLU667
A	ASP665
C	GLU672
C	ASP800
C	ASP802
C	ASP804
C	ILE806
A	GLU667
A	GLU672
A	ASP800
A	ASP802
A	ASP804
A	ILE806
B	ALA662

---

site_id	SWS_FT_FI2
Number of Residues	27
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:24846670, ECO:0007744|PDB:4OKH

Chain	Residue	Details
A	ASP705
B	ASP705
B	ASP707
B	SER709
B	LYS711
B	GLU716
B	ASP735
B	ASP737
B	SER739
B	THR741
C	ASP705
A	ASP707
C	ASP707
C	SER709
C	LYS711
C	GLU716
C	ASP735
C	ASP737
C	SER739
C	THR741
A	SER709
A	LYS711
A	GLU716
A	ASP735
A	ASP737
A	SER739
A	THR741

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448

Chain	Residue	Details
A	GLU746
B	GLU746
C	GLU746

---