Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4OJK

Structure of the cGMP Dependent Protein Kinase II and Rab11b Complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001881	biological_process	receptor recycling
A	0003924	molecular_function	GTPase activity
A	0003925	molecular_function	G protein activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0008021	cellular_component	synaptic vesicle
A	0015031	biological_process	protein transport
A	0016787	molecular_function	hydrolase activity
A	0019003	molecular_function	GDP binding
A	0030670	cellular_component	phagocytic vesicle membrane
A	0030672	cellular_component	synaptic vesicle membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0031489	molecular_function	myosin V binding
A	0032402	biological_process	melanosome transport
A	0032456	biological_process	endocytic recycling
A	0033572	biological_process	transferrin transport
A	0035773	biological_process	insulin secretion involved in cellular response to glucose stimulus
A	0044070	biological_process	regulation of monoatomic anion transport
A	0045054	biological_process	constitutive secretory pathway
A	0045055	biological_process	regulated exocytosis
A	0045296	molecular_function	cadherin binding
A	0045335	cellular_component	phagocytic vesicle
A	0055037	cellular_component	recycling endosome
A	0055038	cellular_component	recycling endosome membrane
A	0070062	cellular_component	extracellular exosome
A	0071468	biological_process	cellular response to acidic pH
A	0090150	biological_process	establishment of protein localization to membrane
A	0098876	biological_process	vesicle-mediated transport to the plasma membrane
A	0150093	biological_process	amyloid-beta clearance by transcytosis
A	1902017	biological_process	regulation of cilium assembly
A	2000008	biological_process	regulation of protein localization to cell surface
A	2001135	biological_process	regulation of endocytic recycling
B	0000166	molecular_function	nucleotide binding
B	0001881	biological_process	receptor recycling
B	0003924	molecular_function	GTPase activity
B	0003925	molecular_function	G protein activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0008021	cellular_component	synaptic vesicle
B	0015031	biological_process	protein transport
B	0016787	molecular_function	hydrolase activity
B	0019003	molecular_function	GDP binding
B	0030670	cellular_component	phagocytic vesicle membrane
B	0030672	cellular_component	synaptic vesicle membrane
B	0031410	cellular_component	cytoplasmic vesicle
B	0031489	molecular_function	myosin V binding
B	0032402	biological_process	melanosome transport
B	0032456	biological_process	endocytic recycling
B	0033572	biological_process	transferrin transport
B	0035773	biological_process	insulin secretion involved in cellular response to glucose stimulus
B	0044070	biological_process	regulation of monoatomic anion transport
B	0045054	biological_process	constitutive secretory pathway
B	0045055	biological_process	regulated exocytosis
B	0045296	molecular_function	cadherin binding
B	0045335	cellular_component	phagocytic vesicle
B	0055037	cellular_component	recycling endosome
B	0055038	cellular_component	recycling endosome membrane
B	0070062	cellular_component	extracellular exosome
B	0071468	biological_process	cellular response to acidic pH
B	0090150	biological_process	establishment of protein localization to membrane
B	0098876	biological_process	vesicle-mediated transport to the plasma membrane
B	0150093	biological_process	amyloid-beta clearance by transcytosis
B	1902017	biological_process	regulation of cilium assembly
B	2000008	biological_process	regulation of protein localization to cell surface
B	2001135	biological_process	regulation of endocytic recycling

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	BINDING SITE FOR RESIDUE GDP A 301

Chain	Residue
A	ASP19
A	LEU38
A	GLU39
A	LYS41
A	ARG74
A	ALA75
A	ASN124
A	LYS125
A	ASP127
A	LEU128
A	SER154
A	GLY21
A	ALA155
A	LEU156
A	HOH401
A	VAL22
A	GLY23
A	LYS24
A	SER25
A	ASN26
A	PHE36
A	ASN37

site_id	AC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE GDP B 301

Chain	Residue
B	ASP19
B	GLY21
B	VAL22
B	GLY23
B	LYS24
B	SER25
B	ASN26
B	PHE36
B	ASN37
B	LEU38
B	GLU39
B	ASN124
B	LYS125
B	ASP127
B	SER154
B	ALA155
B	LEU156

Functional Information from PROSITE/UniProt

site_id	PS00675
Number of Residues	14
Details	SIGMA54_INTERACT_1 Sigma-54 interaction domain ATP-binding region A signature. VVLiGDSGVGKsnL

Chain	Residue	Details
A	VAL14-LEU27

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	11
Details	Motif: {"description":"Switch 1","evidences":[{"source":"PubMed","id":"16545962","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2F9L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2F9M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	19
Details	Motif: {"description":"Switch 2","evidences":[{"source":"PubMed","id":"16545962","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2F9L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2F9M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	27
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16545962","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2F9M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16545962","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2F9L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2F9M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16545962","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2F9M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)