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4OGC

Crystal structure of the Type II-C Cas9 enzyme from Actinomyces naeslundii

Functional Information from GO Data
ChainGOidnamespacecontents
A0003676molecular_functionnucleic acid binding
A0003677molecular_functionDNA binding
A0003723molecular_functionRNA binding
A0004519molecular_functionendonuclease activity
A0008270molecular_functionzinc ion binding
A0046872molecular_functionmetal ion binding
A0051607biological_processdefense response to virus
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN A 1201
ChainResidue
ACYS566
ACYS569
ACYS602
AARG604
ACYS605

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MN A 1202
ChainResidue
AASP17
AHIS736
AASP739
AHOH1302

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG A 1203
ChainResidue
AGLN586
AGLY588
AGLY590
AHOH1301
AHOH1303
AHOH1309

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG A 1204
ChainResidue
AASP581
AASN606
AHOH1304
AHOH1305
AHOH1306
AHOH1307

site_idAC5
Number of Residues9
DetailsBINDING SITE FOR RESIDUE SPD A 1205
ChainResidue
AMSE675
ASER704
AALA708
AALA712
ALEU754
AARG757
ASER758
AARG761
ATRP773

site_idAC6
Number of Residues2
DetailsBINDING SITE FOR RESIDUE MN A 1206
ChainResidue
AASP17
AGLU505

site_idAC7
Number of Residues1
DetailsBINDING SITE FOR RESIDUE ACT A 1207
ChainResidue
AHIS1074

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: For RuvC-like nuclease domain => ECO:0000250|UniProtKB:Q99ZW2
ChainResidueDetails
AASP17

site_idSWS_FT_FI2
Number of Residues1
DetailsACT_SITE: Proton acceptor for HNH nuclease domain => ECO:0000269|PubMed:24505130
ChainResidueDetails
AHIS582

site_idSWS_FT_FI3
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:24505130
ChainResidueDetails
AASP17
ACYS605
AASN606
AHIS736
AGLU505
ACYS566
ACYS569
AASP581
AGLN586
AGLY588
AGLY590
ACYS602

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PDB entries from 2024-11-06

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