4OB5

Ontogeny of recognition specificity and functionality for the broadly neutralizing anti-HIV antibody 4E10

Functional Information from GO Data

Chain	GOid	namespace	contents
L	0002250	biological_process	adaptive immune response
L	0002376	biological_process	immune system process
L	0003094	biological_process	glomerular filtration
L	0003823	molecular_function	antigen binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0005886	cellular_component	plasma membrane
L	0006955	biological_process	immune response
L	0016020	cellular_component	membrane
L	0019731	biological_process	antibacterial humoral response
L	0019814	cellular_component	immunoglobulin complex
L	0070062	cellular_component	extracellular exosome
L	0071748	cellular_component	monomeric IgA immunoglobulin complex
L	0071751	cellular_component	secretory IgA immunoglobulin complex
L	0071756	cellular_component	pentameric IgM immunoglobulin complex
L	0072562	cellular_component	blood microparticle

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL L 201

Chain	Residue
L	GLN37
L	GLN38
L	LYS39
L	GLN42
L	ALA43
L	ARG45
L	HOH357

---

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL L 202

Chain	Residue
L	SER63
L	GLY64
L	SER67
L	GLY68
L	THR69
L	ASP70
L	HOH323
L	SER52
L	ARG54

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL L 203

Chain	Residue
H	GLY15
H	GLY42
L	GLY9
L	GLN100
L	GLY101
L	HOH383

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE TMO L 204

Chain	Residue
H	THR97
H	GLN101
L	TYR49
L	ALA55
L	THR56

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	95
Details	Domain: {"description":"Ig-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	22
Details	Region: {"description":"Framework-1","evidences":[{"source":"UniProtKB","id":"P01602","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	11
Details	Region: {"description":"Complementarity-determining-1","evidences":[{"source":"UniProtKB","id":"P01602","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	14
Details	Region: {"description":"Framework-2","evidences":[{"source":"UniProtKB","id":"P01602","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Region: {"description":"Complementarity-determining-2","evidences":[{"source":"UniProtKB","id":"P01602","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	31
Details	Region: {"description":"Framework-3","evidences":[{"source":"UniProtKB","id":"P01602","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	Region: {"description":"Complementarity-determining-3","evidences":[{"source":"UniProtKB","id":"P01602","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---